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Molecular Cancer
Scopus
ISSN 1476-4598 · BMC · 3.337 artikel di indeks
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Artikel Jurnal
Modeling pediatric low-grade glioma heterogeneity using human forebrain organoids
Abstract Pediatric low-grade gliomas (pLGGs) are the most common type of brain tumors in children, characterized by their typically slow growth and oncogene-induced senescence. Preclinical models provide the opportunity to investigate the effects of various treatments in a controlled setting before…
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Artikel Jurnal
DCLK1 drives malignant progression and chemoresistance of bladder cancer by deubiquitinating HDAC6
Abstract Background Bladder cancer (BC) is the most common malignancy of the urinary system, with rising incidence and mortality. Advanced BC frequently recurs or metastasizes and is often refractory to curative surgical intervention. Although cisplatin-based chemotherapy remains the standard…
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Artikel Jurnal
CircROR1 binds HNRNPL to regulate FOXO4 pre-mRNA splicing, promoting cutaneous melanoma metastasis and serving as a therapeutic target via RNAi-loaded PEG-LNPs
Abstract Background Circular RNAs (circRNAs) contribute to gene expression regulation by interacting with splicing factors, a process that is often disrupted in cancers such as cutaneous melanoma (CM). Methods A circRNA microarray analysis was performed to identify differentially expressed…
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Artikel Jurnal
A KLF5’s domino effect drives metastatic pancreatic cancer
Abstract Pancreatic ductal adenocarcinoma (PDAC) is the 3rd leading cause of cancer mortality in the U.S., where more than 80% of the cases are diagnosed with metastatic PDAC (mPDAC). In this study, Maeda et al. utilized a CRISPR screen in human patient-derived xenografts from primary and lung…
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Artikel Jurnal
Ferroptosis and metastasis: molecular checkpoints, microenvironmental dynamics, and therapeutic opportunities
Abstract Ferroptosis is a non-apoptotic form of regulated cell death driven by iron dependent lipid peroxidation. It sits at the intersection of several hallmarks of metastatic cancer, including metabolic rewiring, membrane remodeling, epithelial mesenchymal plasticity, immune editing, and…
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Artikel Jurnal
Intratumoral microbiome: the double-edged sword in remodeling cancer immunotherapy
Abstract Emerging evidence reveals that intratumoral microbial (ITM) communities within the tumor immune microenvironment (TIME) critically influence tumor progression and immunotherapy response. Studies have shown that resident bacteria within tumors, such as Sphingobacterium multivorum, regulate…
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Artikel Jurnal
Notch signaling in the tumor microenvironment: recent advances and targeted therapeutics
Abstract The Notch signaling pathway, an evolutionarily conserved mechanism governing cell-cell communication, plays a pivotal and multifaceted role in shaping the tumor microenvironment (TME). This review provides a comprehensive overview of the core components and signaling mechanisms of the…
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Artikel Jurnal
Fusobacterium nucleatum manipulates host autophagy to promote its intracellular survival and treatment resistance in nasopharyngeal carcinoma
Abstract Background Growing evidence highlights the existence and tumor-promoting role of intratumoral bacteria in various types of cancers. However, the mechanisms enabling the intracellular survival of these microorganisms remain poorly understood, impeding the development of microbiota-targeting…
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Artikel Jurnal
CircKIAA1617 promotes stemness via USP14/PGRMC1-mediated autophagy and lipid metabolism reprogramming in ER-positive breast cancer
Abstract Background Breast cancer (BC) is the most common neoplasm in women, and its growth mainly depends on estrogen, but the mechanism of estrogen in BC is still not fully understood. Circular RNAs (circRNAs) represent a novel type of regulatory RNA characterized by high evolutionary…
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Artikel Jurnal
Single-cell omics in tumor lymph node metastasis: mechanisms and therapeutic implications
Abstract Lymph node metastasis (LNM) represents a distinctive stage in cancer progression, exerting a profound impact on patient prognosis. Accumulating studies have unveiled that tumor-draining lymph nodes (TDLNs) play a pivotal role in immunotherapy, functioning as an armory for anti-tumor…
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Artikel Jurnal
METTL3-mediated m6A modification of CACNA1E promotes osteosarcoma progression and chemoresistance by enhancing WNT7B-mediated Ca2+ signaling
Abstract Background Osteosarcoma (OS) is the most prevalent primary cancer of the bone. Metastasis and chemoresistance are the major obstacles to the improvement of OS prognosis, in which N6-methyladenosine (m6A) modification plays an important role, but the exact molecular mechanisms are still…
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Artikel Jurnal
Lactylation in cancer: molecular mechanisms and advances in clinical study
Abstract Lysine lactylation (Kla), first described in 2019, is an emerging post-translational modification that converts lactate availability into changes in chromatin state and protein function. In cancer, where glycolysis and microenvironmental hypoxia often elevate lactate, lactylation has been…
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Artikel Jurnal
Ferroptosis in cancer toward molecular insights and clinical translation in pancreatic cancer
Abstract Ferroptosis is a regulated form of cell death driven by iron accumulation and lipid peroxidation. Since its recognition as a modality of regulated cell death, ferroptosis has attracted increasing attention in cancer research for its distinct metabolic and redox dependencies. Recent…
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Artikel Jurnal
LncRNA PVT1 in human cancers: genomic complexity, isoforms, functional elements, mechanism of action, subcellular localization and possible role as a therapeutic target
Abstract PVT1 (Plasmacytoma Variant Translocation 1), a long non-coding RNA (lncRNA), is a critical player in diverse biological processes, particularly cancer biology. This review comprehensively examines PVT1’s multifaceted roles and molecular mechanisms. We delve into its predominant oncogenic…
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Artikel Jurnal
piR-1170 drives brain metastasis and immune evasion via WTAP-mediated m6A methylation reprogramming in triple-negative breast cancer
Abstract Therapeutic target for triple-negative breast cancer (TNBC) brain metastases remains a critical unmet clinical challenge. The roles of PIWI-interacting RNAs (piRNAs) in driving brain metastasis are poorly understood, despite their known dysregulation and oncogenic functions in cancer…
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Artikel Jurnal
Metabolic reprogramming in cancer: signaling pathways and therapeutic targets
Abstract Metabolism is a general term for an ordered series of chemical reactions used to maintain life, and the maintenance of normal cellular activities cannot be separated from metabolism, which is the most basic feature of life. However, metabolic alterations have a dual role. In normal cells…
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Artikel Jurnal
Tumor microenvironment dynamics in gastric cancer pathogenesis and therapeutic resistance
Abstract Gastric cancer remains a significant global health challenge due to its high incidence and mortality, and limited treatment options in advanced stages. Notably, gastric cancer exhibits a complex tumor microenvironment (TME) with substantial cellular and spatial heterogeneity, which…
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Artikel Jurnal
Cancer stem cell-driven drug resistance in colorectal carcinoma: molecular aspects and therapeutic potentials
Abstract Colorectal cancer (CRC) remains a major global health burden, with therapeutic resistance accounting for the majority of treatment failures and cancer-related deaths. Cancer stem cells (CSCs), which possess intrinsic drug tolerance and self-renewal capacity, drive both primary and acquired…
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Artikel Jurnal
A pan-cancer single cell landscape reveals heterogeneity and functional diversity of double-negative T cells
Abstract Background Double-Negative T (DNT) cells, lacking both CD4 and CD8 expression, play critical roles in cancer immunology, and have garnered increasing attention in cancer research. However, their heterogeneity and functional diversity within the tumor microenvironment (TME) remain…
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