13 hasil untuk "Machado de Assis"
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Artikel Jurnal Teks lengkap
Predictive Models for the Diagnostic of Human Visceral Leishmaniasis in Brazil
Background and Objectives: In Brazil, as in many other affected countries, a large proportion of visceral leishmaniasis (VL) occurs in remote locations and treatment is often performed on basis of clinical suspicion. This study aimed at developing predictive models to help with the clinical…
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Intralesional infiltration versus parenteral use of meglumine antimoniate for treatment of cutaneous leishmaniasis: A cost-effectiveness analysis
Cutaneous leishmaniasis (LC) is a complex and variable disease in terms of epidemiology, aetiology, pathology and clinical characteristics. The mainstay of treatment is still pentavalent antimony (Sbv) compounds administered systemically, despite their recognized toxicity. The advantages of…
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Diagnosis of human brucellosis: Systematic review and meta-analysis
Background: Brucellosis, a widely spread zoonotic disease, poses significant diagnostic challenges due to its non-specific symptoms and underreporting. Timely and accurate diagnosis is crucial for effective patient management and public health control. However, a comprehensive comparative review of…
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Cost-effectiveness of serological tests for human visceral leishmaniasis in the Brazilian scenario
Human visceral leishmaniasis (VL) is a severe and potentially fatal parasitic disease if not correctly diagnosed and treated. Brazil is one of the three countries most endemic for VL and, like most countries affected by this disease, has a large budget constraint for the incorporation of new health…
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Cost-effectiveness of anti-SARS-CoV-2 antibody diagnostic tests in Brazil
Background: Although serologic tests for COVID-19 diagnosis are rarely indicated nowadays, they remain commercially available and widely used in Brazil. The objective of this study was to evaluate the cost-effectiveness of anti-SARS-CoV-2antibody diagnostic tests for COVID-19 in Brazil. Methods…
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Effects of cutaneous leishmaniasis on health-related quality of life: A longitudinal approach
Introduction: Cutaneous leishmaniasis (CL) is a neglected tropical disease that significantly affects patients’ physical, psychological, and social well-being. Although previous studies have documented health-related quality of life (HRQoL) impairments associated with CL, most have relied on…
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Quality of life of patients with cutaneous leishmaniasis: A comparative analysis of the EQ-5D-3L and CLIQ questionnaires
Purpose: To evaluate the performance of the Cutaneous Leishmaniasis Impact Questionnaire (CLIQ) using the EuroQol-5 Dimension (EQ-5D-3L) as a reference standard (criterion validation); to evaluate the responsiveness of the instruments and estimate a cut-off point for the CLIQ to be able to…
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The burden of out-of-pocket and indirect costs of cutaneous leishmaniasis patients in Minas Gerais, Brazil
Background: Healthcare expenses represent a proportionally greater burden for the poorest populations, which further exacerbates the negative impact of the disease on the individual’s quality of life and productivity. Objective: The study aimed to identify the direct and indirect costs during the…
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Performance of serological tests available in Brazil for the diagnosis of human visceral leishmaniasis
Background: Visceral leishmaniasis (VL) is the most severe form of leishmaniasis and is potentially fatal if not diagnosed and treated. Accurate and timely diagnosis is considered one of the pillars needed for the reduction in disease-related lethality. Brazil is currently one of the three…
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Immune Activation and Bacterial Translocation: A Link between Impaired Immune Recovery and Frequent Visceral Leishmaniasis Relapses in HIV-Infected Patients
The maintenance of chronic immune activation due to leishmaniasis or even due to microbial translocation is associated with immunosenescence and may contribute to frequent relapses. Our aim was to investigate whether patients with HIV-associated visceral leishmaniasis (VL/HIV) who experience a…
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Health-related quality of life in Brazilian patients with cutaneous leishmaniasis using EQ-5D
Cutaneous leishmaniasis (CL) is a neglected infectious disease with a global distribution and a known health-related quality of life (HRQoL) impact. However, no utility-based HRQoL assessments for CL patients are available. The aim of this study was to quantitatively assess the health-related…
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Impact of age and immune status on the accuracy of rapid diagnostic tests for visceral leishmaniasis in Brazil
Background: Visceral leishmaniasis (VL) represents a significant public health concern due to its high case-fatality, which poses the challenge of a timely and accurate diagnosis. Antibody-based rapid diagnostic tests (RDTs) have emerged as a disruptive innovation in recent years, by offering a…
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Artikel Jurnal Teks lengkap
Long-term outcomes of benznidazole treatment in chronic Chagas disease: A 27-year cohort study of parasitological cure and death in the Jequitinhonha Valley, Brazil
Background: Chagas disease (CD) is a neglected tropical infection prevalent in rural areas of Latin America. The etiological treatment is indicated for patients with both acute and chronic phases of CD, except in the most advanced clinical stage of the disease. However, there are still several…