4 results for "Maria Rodriguez-Rios"

Author Correction: A fluorogenic, peptide-based probe for the detection of Cathepsin D in macrophages

Maria Rodriguez-Rios; Brian J. McHugh; Zhengqi Liang et al.

Communications Chemistry, Vol. 9 No. 1 · 2026 · English · DOAJ Scopus

A fluorogenic, peptide-based probe for the detection of Cathepsin D in macrophages

Maria Rodriguez-Rios; Brian J. McHugh; Zhengqi Liang et al.

Communications Chemistry, Vol. 6 No. 1 · 2023 · English · DOAJ Scopus

Abstract Cathepsin D is a protease that is an effector in the immune response of macrophages, yet to date, only a limited number of probes have been developed for its detection. Herein, we report a water soluble, highly sensitive, pH insensitive fluorescent probe for the detection of Cathepsin D…

BromoCatch: a self-labelling tag platform for protein modification and live cell imaging

Maria Rodriguez-Rios; Conner Craigon; Mark A. Nakasone et al.

Nature Communications, Vol. 17 No. 1 · 2026 · English · DOAJ Scopus

Abstract Visualizing and manipulating proteins in live cells is crucial for studying complex biological processes. Self-labelling protein (SLP) tags such as HaloTag and SNAP-tag are widely used for protein labelling, and new systems are needed to expand multiplexing capabilities and broaden the…

Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders

Alena Kroupova; Valentina A. Spiteri; Zoe J. Rutter et al.

Nature Communications, Vol. 15 No. 1 · 2024 · English · DOAJ Scopus

Abstract The ubiquitin E3 ligase cereblon (CRBN) is the target of therapeutic drugs thalidomide and lenalidomide and is recruited by most targeted protein degraders (PROTACs and molecular glues) in clinical development. Biophysical and structural investigation of CRBN has been limited by current…