11 hasil untuk "Neil Aggarwal"

Urine Complement Factor Ba Identifies Persistent Acute Kidney Injury and Organ Failures in Critically Ill Adults

Erin K. Stenson; Charles E. Edelstein; Zhiying You dkk.

Kidney International Reports, Vol. 10 No. 2 · 2025 · Inggris · DOAJ Scopus

Introduction: Critically ill adults with acute kidney injury (AKI) have high morbidity and mortality and lack treatment options. We assessed the association between complement activation (urine Ba fragment levels), and AKI and organ failures. Methods: A biorepository of critically ill adults was…

Epigenetics may characterize asymptomatic COVID-19 infection

Cosby G. Arnold; Iain Konigsberg; Jason Y. Adams dkk.

Human Genomics, Vol. 16 No. 1 · 2022 · Inggris · DOAJ Scopus

Abstract RT-PCR is the foremost clinical test for diagnosis of COVID-19. Unfortunately, PCR-based testing has limitations and may not result in a positive test early in the course of infection before symptoms develop. Enveloped RNA viruses, such as coronaviruses, alter peripheral blood methylation…

Does a protocolised oxygenation target impact clinical outcomes in mechanically ventilated patients in the intensive care unit across the 10 academic and community hospitals in the UCHealth system? Protocol and statistical analysis plan for an EHR-embedded pragmatic stepped-wedge randomised controlled trial

Bethany M Kwan; Aaron Barbour; Ryan A Peterson dkk.

BMJ Open, Vol. 16 No. 5 · 2026 · Inggris · DOAJ Scopus

Introduction We designed the Optimising Care in Critically Ill at the UCHealth by Liberalising the Target O₂ in Mechanically ventilated intensive care unit (ICU) Patients to determine the effectiveness of a multimodal educational and electronic health record order panel intervention in limiting…

A critical review of the evolution and interrelation of traumatic stress disorders

Ayah Hamadeh; Joseph El-Khoury; Julio Torales dkk.

PLOS Mental Health, Vol. 2 No. 7 · 2025 · Inggris · PLOS Scopus

Trauma is a complex and often contentious psychopathological construct. The term trauma has become ubiquitous within mental health literature and practice. It is often used interchangeably to describe the etiology and the reaction to it. In this article we describe its historical and contemporary…

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235 From barriers to breakthroughs: Addressing accrual barriers in pragmatic EHR-embedded trials

Bethany Kwan; Bethany M. Kwan; Cecilia Low Wang dkk.

Journal of Clinical and Translational Science, Vol. 10 · 2026 · Inggris · DOAJ Scopus

Objectives/Goals: Trial accrual via electronic health records (EHRs) are limited by workflow and communication issues. We used a root cause analysis to identify barriers and guide changes in a pragmatic trial of metformin vs lifestyle change for prostate cancer. The goal is to evaluate strategies…

Statistical analysis plan for the Strategy to Avoid Excessive Oxygen using Autonomous Oxygen Titration Intervention (SAVE-O2 AI) trial: protocol

Matthew W Semler; Amy Sullivan; John D Rice dkk.

BMJ Open, Vol. 16 No. 1 · 2026 · Inggris · DOAJ Scopus

Introduction Administering supplemental oxygen to prevent hypoxaemia is a fundamental treatment for patients hospitalised with acute injury or illness. However, the amount of oxygen administered frequently exceeds that needed to maintain normoxaemia, causing patients to experience hyperoxaemia and…

Building an international precision medicine platform trial for the acute respiratory distress syndrome (ARDS): an expert consensus project report

Kiran Reddy; Neil Aggarwal; Narges Alipanah-Lechner dkk.

Efficacy and Mechanism Evaluation, Vol. 13 No. 07 · 2025 · Inggris · DOAJ

Background Almost all large-scale trials of disease-modifying therapeutic agents in critical care have failed to show benefit for patients, which may be explained in part by the clinical and biological heterogeneity inherent in virtually all critical illness syndromes. Enrichment strategies have…

Report of the first seven agents in the I-SPY COVID trial: a phase 2, open label, adaptive platform randomised controlled trialResearch in context

D. Clark Files; Neil Aggarwal; Timothy Albertson dkk.

EClinicalMedicine, Vol. 58 · 2023 · Inggris · DOAJ Scopus

Summary: Background: An urgent need exists to rapidly screen potential therapeutics for severe COVID-19 or other emerging pathogens associated with high morbidity and mortality. Methods: Using an adaptive platform design created to rapidly evaluate investigational agents, hospitalised patients with…

I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations

Carolyn S Calfee; Michael A Matthay; Paul Henderson dkk.

BMJ Open, Vol. 12 No. 6 · 2022 · Inggris · DOAJ Scopus

Introduction The COVID-19 pandemic brought an urgent need to discover novel effective therapeutics for patients hospitalised with severe COVID-19. The Investigation of Serial studies to Predict Your Therapeutic Response with Imaging And moLecular Analysis (ISPY COVID-19 trial) was designed and…