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Vaccination induces HIV broadly neutralizing antibody precursors in humans

David J. Leggat; Kristen W. Cohen; Jordan R. Willis dkk.

Science · 2022 · Inggris · OpenAlex Scopus

Broadly neutralizing antibodies (bnAbs) can protect against HIV infection but have not been induced by human vaccination. A key barrier to bnAb induction is vaccine priming of rare bnAb-precursor B cells. In a randomized, double-blind, placebo-controlled phase 1 clinical trial, the HIV…