5 hasil untuk "Pascal Carrivain"

In silico single-molecule manipulation of DNA with rigid body dynamics.

Pascal Carrivain; Maria Barbi; Jean-Marc Victor

PLoS Computational Biology, Vol. 10 No. 2 · 2014 · Inggris · DOAJ Scopus

We develop a new powerful method to reproduce in silico single-molecule manipulation experiments. We demonstrate that flexible polymers such as DNA can be simulated using rigid body dynamics thanks to an original implementation of Langevin dynamics in an open source library called Open Dynamics…

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Network Modeling of Crohn's Disease Incidence.

Jean-Marc Victor; Gaëlle Debret; Annick Lesne dkk.

PLoS ONE, Vol. 11 No. 6 · 2016 · Inggris · DOAJ Scopus

Numerous genetic and environmental risk factors play a role in human complex genetic disorders (CGD). However, their complex interplay remains to be modelled and explained in terms of disease mechanisms.Crohn's Disease (CD) was modeled as a modular network of patho-physiological functions, each…

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Direct visualization and tracing of chromatin folding in the Drosophila embryo

Fadwa Fatmaoui; Pascal Carrivain; Fatima Taiki dkk.

The EMBO Journal, Vol. 45 No. 5 · 2026 · Inggris · DOAJ Scopus

Abstract Chromatin organization, through the assembly of DNA with histones and the folding of nucleosome chains, regulates DNA accessibility for transcription, DNA replication and repair. Although models derived from in vitro studies have proposed distinct nucleosome chain geometries, the…