4 hasil untuk "Rob Wolthuis"

MASTL promotes cyclin B1 destruction by enforcing Cdc20-independent binding of cyclin B1 to the APC/C

Erik Voets; Rob Wolthuis

Biology Open, Vol. 4 No. 4 · 2015 · Inggris · DOAJ Scopus

When cells enter mitosis, the anaphase-promoting complex/cyclosome (APC/C) is activated by phosphorylation and binding of Cdc20. The RXXL destruction box (D-box) of cyclin B1 only binds Cdc20 after release of the spindle checkpoint in metaphase, initiating cyclin B1 ubiquitination upon chromosome…

Fragmentomic cfDNA Patterns in Noninvasive Prenatal Testing and Beyond

Kavish Kohabir; Rob Wolthuis; Erik A. Sistermans

Journal of Biomedicine and Translational Research, Vol. 7 No. 1 · 2021 · Inggris · DOAJ

The release of fetoplacental cell-free DNA (cfDNA) into the maternal bloodstream opened up new avenues towards noninvasive prenatal testing (NIPT) for aneuploidies, hereditary DNA mutations and other pregnancy-related developmental disorders. Increasingly, cfDNA catches interest for its noninvasive…

BIRC2–BIRC3 amplification: a potentially druggable feature of a subset of head and neck cancers in patients with Fanconi anemia

Khashayar Roohollahi; Yvonne de Jong; Govind Pai dkk.

Scientific Reports, Vol. 12 No. 1 · 2022 · Inggris · DOAJ Scopus

Abstract Head-and-neck squamous cell carcinomas (HNSCCs) are relatively common in patients with Fanconi anemia (FA), a hereditary chromosomal instability disorder. Standard chemo-radiation therapy is not tolerated in FA due to an overall somatic hypersensitivity to such treatment. The question is…

Publisher Correction: BIRC2–BIRC3 amplification: a potentially druggable feature of a subset of head and neck cancers in patients with Fanconi anemia

Khashayar Roohollahi; Yvonne de Jong; Govind Pai dkk.

Scientific Reports, Vol. 12 No. 1 · 2022 · Inggris · DOAJ Scopus