7 results for "Roderick J. Tan"

The Many Faces of Matrix Metalloproteinase-7 in Kidney Diseases

Zhao Liu; Roderick J. Tan; Youhua Liu

Biomolecules, Vol. 10 No. 6 · 2020 · English · DOAJ Scopus

Matrix metalloproteinase-7 (MMP-7) is a secreted zinc-dependent endopeptidase that is implicated in regulating kidney homeostasis and diseases. MMP-7 is produced as an inactive zymogen, and proteolytic cleavage is required for its activation. MMP-7 is barely expressed in normal adult kidney but…

NRF2 in kidney physiology and disease

Corry D. Bondi; Hannah L. Hartman; Roderick J. Tan

Physiological Reports, Vol. 12 No. 5 · 2024 · English · DOAJ Scopus

Abstract The role of NRF2 in kidney biology has received considerable interest over the past decade. NRF2 transcriptionally controls genes responsible for cellular protection against oxidative and electrophilic stress and has anti‐inflammatory functions. NRF2 is expressed throughout the kidney and…

Endothelin receptor a blockade is an ineffective treatment for adriamycin nephropathy.

Roderick J Tan; Lili Zhou; Dong Zhou et al.

PLoS ONE, Vol. 8 No. 11 · 2013 · English · DOAJ Scopus

Endothelin is a vasoconstricting peptide that plays a key role in vascular homeostasis, exerting its biologic effects via two receptors, the endothelin receptor A (ETA) and endothelin receptor B (ETB). Activation of ETA and ETB has opposing actions, in which hyperactive ETA is generally…

Also available at: PLOS

IL-17 Receptor Signaling Negatively Regulates the Development of Tubulointerstitial Fibrosis in the Kidney

Kritika Ramani; Roderick J. Tan; Dong Zhou et al.

Mediators of Inflammation, Vol. 2018 · 2018 · English · DOAJ Scopus

Chronic inflammation has an important role in the development and progression of most fibrotic diseases, for which no effective treatments exist. Tubulointerstitial fibrosis (TF) is characterized by irreversible deposition of fibrous tissue in chronic kidney diseases. Prolonged injurious stimuli…

Suppression of NRF2 Activity by HIF-1α Promotes Fibrosis after Ischemic Acute Kidney Injury

Corry D. Bondi; Brittney M. Rush; Hannah L. Hartman et al.

Antioxidants, Vol. 11 No. 9 · 2022 · English · DOAJ Scopus

Acute kidney injury (AKI) is a rapid decline in renal function and can occur after ischemia/reperfusion injury (IRI) to the tubular epithelia. The nuclear factor erythroid-2-related factor 2 (NRF2) pathway protects against AKI and AKI-to-chronic kidney disease (CKD) progression, but we previously…

Megalin Knockout Reduces SGLT2 Expression and Sensitizes to Western Diet-induced Kidney Injury

Elynna B Youm; Katherine E Shipman; Wafaa N Albalawy et al.

Function, Vol. 5 No. 4 · 2024 · English · DOAJ Scopus

Abstract Megalin (Lrp2) is a multiligand receptor that drives endocytic flux in the kidney proximal tubule (PT) and is necessary for the recovery of albumin and other filtered proteins that escape the glomerular filtration barrier. Studies in our lab have shown that knockout (KO) of Lrp2 in opossum…