81 hasil untuk "Rodriguez G."
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A measurement of the muon number in showers using inclined events detected at the Pierre Auger Observatory
The average muon content of measured showers with zenith angles between 62∘ and 80∘ detected at the Pierre Auger Observatory is obtained as a function of shower energy using a reconstruction method specifically designed for inclined showers and the hybrid character of the detector. The…
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Effect of stimulus intensity on latent inhibition: A case for generalization decrement.
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Four Channel Mini Wire Chamber to Study Cosmic Rays
Multiwire proportional chamber is a conventional technique to study radiation in general, and cosmic rays in particular. To study cosmic rays, it was planned, designed, constructed, characterized, and tested a four channel mini wire chamber, based on two 3 cm × 3 cm × 0.6 cm Aluminum frames, two 3…
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Procesos de antropización y cambios en el paisaje vegetal del País Vasco atlántico en la prehistoria reciente : su incidencia en la expansión de hayedos encinares
En este trabajo se presentan los resultados de algunos estudios arqueobotánicos que permiten valorar la incidencia de los procesos de antropización del medio en la transformación del paisaje vegetal del País Vasco Atlántico en la Prehistoria reciente. De manera central, se analizan y, en su caso…
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IdeR is required for iron homeostasis and virulence in Mycobacterium tuberculosis
Iron is an essential but potentially harmful nutrient, poorly soluble in aerobic conditions, and not-freely available in the human host. To acquire iron, bacteria have evolved high affinity iron acquisition systems that are expressed under iron limitation often in conjunction with virulence…
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A Ferritin Mutant of Mycobacterium tuberculosis Is Highly Susceptible to Killing by Antibiotics and Is Unable To Establish a Chronic Infection in Mice
Iron is an essential, elusive, and potentially toxic nutrient for most pathogens, including Mycobacterium tuberculosis. Due to the poor solubility of ferric iron under aerobic conditions, free iron is not found in the host. M. tuberculosis requires specialized iron acquisition systems to replicate…
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Identification of an ABC Transporter Required for Iron Acquisition and Virulence in Mycobacterium tuberculosis
Iron availability affects the course of tuberculosis infection, and the ability to acquire this metal is known to be essential for replication of Mycobacterium tuberculosis in human macrophages. M. tuberculosis overcomes iron deficiency by producing siderophores. The relevance of siderophore…
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SUBJECTIVE MEMORY COMPLAINTS, LEARNING POTENTIAL, AND OBJECTIVE COGNITIVE FUNCTIONING IN OLDER ADULTS
Introduction: Subjective memory complaints in older adults should not be considered only as an age-related phenomenon or a symptom of depression. Instead, these complaints deserve to be taken seriously, at least as a possible early sign of dementia. Methods: Cross-sectional study, n= 201 older…
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Mycobacterial extracellular vesicles and host pathogen interactions
Mycobacteria, like other bacteria, archaea and eukaryotic cells, naturally release extracellular vesicles (EVs) to interact with their environment. EVs produced by pathogenic bacteria are involved in many activities including cell–cell communication, immunomodulation, virulence and cell survival…
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Metallobiology of Tuberculosis
Transition metals are essential constituents of all living organisms, playing crucial structural and catalytic parts in many enzymes and transcription factors. However, transition metals can also be toxic when present in excess. Their uptake and efflux rates must therefore be carefully controlled…
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Examining the role of Rv2895c (viuB) in iron acquisition in Mycobacterium tuberculosis
Iron acquisition is essential for Mycobacterium tuberculosis (Mtb) virulence. Understanding the molecular mechanisms used by Mtb to scavenge iron during infection might reveal new targets for antimicrobial development. Rv2895c, a homolog of ViuB from Vibrio cholerae has been postulated to be…
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Oral ciprofloxacin compared with parenteral antibiotics in the treatment of osteomyelitis.
We undertook a prospective, randomized comparison of oral ciprofloxacin with standard parenteral therapies for the treatment of biopsy-proven osteomyelitis caused by susceptible organisms. Following surgical debridement, the ciprofloxacin patients received 750 mg twice a day, and the other patients…
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Functions and importance of mycobacterial extracellular vesicles
The release of cellular factors by means of extracellular vesicles (EVs) is conserved in archaea, bacteria and eukaryotes. EVs are released by growing bacteria as part of their interaction with their environment and, for pathogenic bacteria, constitute an important component of their interactions…
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Mesoamerican Nephropathy (MeN): What We Know so Far
Vicente Sanchez Polo,1 Ramon Garcia-Trabanino,2,3 Guillermo Rodriguez,4 Magdalena Madero5 1Instituto Guatemalteco de Seguridad Social, Guatemala, Guatemala; 2Centro de Hemodiálisis, San Salvador, El Salvador; 3Fondo Social de Emergencia Para la Salud, Tierra Blanca, El Salvador; 4Service of…
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Sembrando código, cosechando pensamiento: una estrategia pedagógica para el desarrollo del pensamiento computacional en contextos rurales
El desarrollo del pensamiento computacional en la educación básica se ha consolidado como una prioridad en los sistemas educativos contemporáneos, especialmente en contextos donde las brechas digitales limitan el acceso a herramientas tecnológicas. El presente artículo analiza la implementación del…
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Vaccination with an Attenuated Ferritin Mutant Protects Mice against Virulent Mycobacterium tuberculosis
Mycobacterium tuberculosis the causative agent of tuberculosis affects millions of people worldwide. New tools for treatment and prevention of tuberculosis are urgently needed. We previously showed that a ferritin (bfrB) mutant of M. tuberculosis has altered iron homeostasis and increased…
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Effect of Iron Supplementation on the Outcome of Non-Progressive Pulmonary Mycobacterium tuberculosis Infection
The human response to Mycobacterium tuberculosis (Mtb) infection is affected by the availability of iron (Fe), which is necessary for proper immune cell function and is essential for the growth and virulence of bacteria. Increase in host Fe levels promotes Mtb growth and tuberculosis (TB)…
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The Iron Response of Mycobacterium tuberculosis and Its Implications for Tuberculosis Pathogenesis and Novel Therapeutics
Most pathogenic bacteria require iron for growth. However, this metal is not freely available in the mammalian host. Due to its poor solubility and propensity to catalyze the generation of reactive oxygen species, host iron is kept in solution bound to specialized iron binding proteins. Access to…
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Sepsis: a study of physician's knowledge about the Surviving Sepsis Campaign in Puerto Rico