87 results for "Ruby Dhar"
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Journal Article
Ranking prognosis: Future perspective of RANK/RANKL in breast cancer
With over 2.3 million new cases and 685,000 deaths, breast cancer is the most commonly diagnosed cancer worldwide, and its burden has been rising over the past decades. In India, the incidence increased significantly, almost 50%, between 1965 and 1985. As per the 2020 Globocan information, in…
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Spatial transcriptomics: Gene expression in space, time and numbers
Eukaryotic gene expression is an array of complex processes that must fine-tune with cellular needs to maintain homeostasis, yet flexible enough to respond to external cues and signals. Transcriptomics is the average output of cellular gene expression wherein messenger RNA copy the information…
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The science of “smell” and the noble for “hugs:” making “sense?”
David Julius and Ardem Patapoutian were jointly awarded the 2021 Nobel Prize in Physiology and Medicine for their discoveries of receptors for temperature and touch. It was a phenomenal moment for the scientific community, more for the discovery that forms the basic fabric of our everyday life—ever…
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Extrachromosomal DNA : New Players in Oncology
DNA that is found outside the main chromosomes in a cell's nucleus is known as extrachromosomal DNA. This type of DNA is not part of the standard 23 pairs of chromosomes in humans and instead exists as standalone circular or linear DNA structures. Unlike bacterial plasmids, extrachromosomal DNA in…
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The hidden threat: How environmental pollution imperils maternal and fetal health
The intricate story of human development begins long before conception, shaped by the environmental milieu that surrounds expectant mothers. As our world grapples with unprecedented levels of environmental contamination, mounting evidence reveals a disturbing reality: the air we breathe, the water…
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The obesity-cancer nexus: A growing global health crisis demanding urgent action
The intersection of obesity and cancer represents a critical global health crisis requiring urgent attention and coordinated intervention strategies. With over 650 million adults worldwide classified as obese, epidemiological evidence demonstrates that excess adiposity significantly increases risk…
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Advancing maternal–fetal research: The promise of placental perfusion models
The human placenta serves as the critical interface between maternal and fetal circulation, orchestrating nutrient transfer, waste elimination, and hormone production throughout pregnancy. Understanding placental function has profound implications for maternal and neonatal health, yet studying this…
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The silent crisis: Occupational health hazards in India’s expanding industrial landscape
India’s rapid industrialization comes at a significant human cost, with workplace safety emerging as one of the nation’s most pressing public health crises. According to data compiled by IndustriALL, by December 10, 2024, at least 240 workplace accidents occurred in the manufacturing, mining, and…
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Journal Article
Decoding cardio-kidney-metabolic disease networks: A proteogenomic roadmap to precision therapeutics
The emerging paradigm of cardio-kidney-metabolic (CKM) diseases as interconnected pathophysiological entities has been revolutionized by this comprehensive multi-omics investigation by Hirohama et al., which demonstrates that tissue-specific proteomics provides unique mechanistic insights beyond…
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Digital twins in oncology: Revolutionising precision cancer care
The emergence of digital twin technology represents a paradigm shift in precision oncology, offering unprecedented opportunities to transform how we diagnose, treat, and monitor cancer patients. Originally conceived in aerospace and manufacturing industries, digital twins – dynamic virtual replicas…
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Journal Article
Indian twin registry: A gold mine for genetic studies
Twins are a source of curiosity, both for the family and the scientific community. Genetic similarities between twins have been the preferred choice to study the heritability of traits. The fact that nature and nurture play a significant role in shaping one’s phenotype has prompted Geneticists to…
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Checkmate with checkpoint inhibitors: New paradigm in immunotherapy
Cancer immunotherapy is a form of biotherapy (also called biological response modifier therapy) that refers to a broad array of anti-cancer therapies targeted to activate and trigger the body’s immune system against cancer. This includes targeted antibodies to specific cell surface entities on…
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Tree elements: Branching hopes after tissue injury in regenerative medicine
Humans are poor model systems for studying tissue regeneration. Unlike their amphibians or rodent counterparts, humans are deficient in this quality, making the repair process following a tissue injury infrequent and limited. Most human tissues or organs, except the liver, lack in their…
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Journal Article
Uridine as a novel fuel for cancer cells
Cancer cells are known to have an enormous appetite for calorie. This is something they are addicted to sustain their unrestricted growth and rapid proliferation. In order to accomplish this feat, cancer cells has evolved multiple mechanisms, rewiring their metabolic circuitry such that metabolic…
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Journal Article
Gestational diabetes: The epicenter of feto-maternal crisis
Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance with onset or first recognition during pregnancy. The rising trend in obesity and overweight globally poses a serious risk for developing GDM, more among South Asian population. The occurrence of perinatal…
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Smart wearable devices for real-time health monitoring
Smartwatches have emerged as powerful tools for health monitoring in recent years. These wearable devices combine advanced technology with portability, enabling individuals to track various aspects of their health and well-being conveniently. Heart rate monitoring has several advantages. Many…
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Journal Article
Menopause and COVID19 severity: The missing link
COVID-19 pandemic has far-reaching consequences on people with comorbidities like Diabetes Mellitus (DM), asthma, cardiovascular disease, and cancer. What seems unusual is an isolated observation that emerged from several independent studies worldwide. Postmenopausal females seem to suffer from…
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Artificial intelligence in healthcare: Setting new algo RHYTHM in medicine
Artificial intelligence (AI) is a rapidly expanding avenue in science and is often used to describe the use of computers, big data mining, modeling, and network that may simulate intelligent behavior and critical thinking similar to a human being but at an exceedingly fast pace. What lies at the…
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Neglected tropical disease: Why we need to prioritize them more
Neglected tropical diseases (NTDs) are those that are commonly found in several low-income countries in Africa, Asia, and Latin America and where people do not have access to hygiene, clean water, or safe ways to dispose of human waste. NTDs comprise a diverse group of diseases that is highly…