12.016 hasil
Menampilkan 1–20 · 0,21 detik · RSS
Frontiers in Bioengineering and Biotechnology
Scopus
ISSN 2296-4185 · Frontiers Media S.A. · 12.016 artikel di indeks
-
Artikel Jurnal
Correlation between quadriceps activation and proprioception in patients with knee osteoarthritis
ObjectiveTo investigate the correlation between the activation status of quadriceps muscle and the proprioceptive accuracy in patients with knee osteoarthritis (KOA).MethodsWe included 43 outpatients diagnosed with KOA and 45 health subjects from October 2024 to May 2025. The correlation between…
-
Artikel Jurnal
Towards a cleaner CHO chassis: systematic knockout of host cell proteins for efficient biopharmaceutical manufacturing
Host cell proteins (HCPs) are major process‐related impurities in biopharmaceutical manufacturing, imposing metabolic burden on production hosts and complicating downstream purification, thereby impacting cost, product stability, and patient safety. Here, we engineered Chinese hamster ovary (CHO)…
-
Artikel Jurnal
Therapeutic effects of stem cell–derived extracellular vesicles in animal models of intervertebral disc degeneration: a systematic review and meta-analysis of species differences and delivery strategies
ObjectivesIntervertebral disc degeneration (IVDD) is a major contributor to chronic low back pain and disability worldwide, yet current treatments remain largely palliative and do not restore disc structure or biomechanical integrity. Stem cell–derived extracellular vesicles (SC-sEVs) have emerged…
-
Artikel Jurnal
Optimization of mannanase expression in Aspergillus niger for enhanced production of mannan oligosaccharides
Mannan oligosaccharides (MOS) are high-value prebiotics widely applied in the food, feed, and pharmaceutical industries. Mannanase, as the key rate-limiting enzyme in the biosynthesis of MOS, directly determines MOS yield and production cost based on its expression level. However, current…
-
Artikel Jurnal
A hybrid vocal fold phonatory platform for pediatric phonation modeling
Understanding pediatric phonation requires models that capture the biomechanical properties and dynamic airflow interactions of vocal folds. While synthetic vocal fold models have advanced the study of airflow–structure interactions in phonation, they cannot incorporate biologically relevant…
-
Artikel Jurnal
Shunt configuration’s role in shaping hemodynamics of reverse Potts shunt in pediatric pulmonary arterial hypertension
ObjectivesReverse Potts shunt is a promising yet high-risk therapy for pediatric pulmonary arterial hypertension. Postoperative hemodynamics is critically influenced by shunt configuration but is difficult to predict. This study aimed to quantify the effects of shunt size and location on…
-
Artikel Jurnal
Platelet-rich plasma-enhanced “plum blossom” bone grafting for refractory femoral nonunion: a single-center study of 33 cases
BackgroundRevision surgery for femoral nonunion is technically challenging, and there is limited evidence supporting effective treatments for cases with multiple failed revisions. This study aims to evaluate the efficacy of platelet-rich plasma-enhanced “plum blossom” bone grafting combined with a…
-
Artikel Jurnal
The influence of different surface texture parameters on the cell proliferation and adhesion early behaviors on the surface of titanium alloy
Current clinical practice has extensively validated the efficacy of left ventricular assist devices (LVADs) in managing end-stage heart failure. A persistent challenge across all ventricular assist systems involves achieving optimal biocompatibility at the critical interface between the LVAD outlet…
-
Artikel Jurnal
Experimental determination of effective X-ray attenuation coefficients of 3D-printed materials under clinical mammography spectra
Background3D printing enables the fabrication of customized breast phantoms for image quality assessment in digital mammography (DM) and digital breast tomosynthesis (DBT). A major challenge is the absence of standardized, accessible methods to characterize the attenuation properties of 3D-printed…
-
Artikel Jurnal
Research progress on mitochondria in bone defect repair: mechanisms and therapeutic implications
Bone defect repair faces clinical challenges due to complex conditions caused by various factors such as trauma and aging. Traditional treatments have certain limitations, which seriously affect patients’ prognosis. As the core organelle of cells, mitochondria regulate the activity of key cells…
-
Artikel Jurnal
Suppression of exosomal miR-199a-3p, a differentially expressed miRNA in steroid-induced osteonecrosis of the femoral head, promotes cell proliferation, osteogenesis, and angiogenesis while inhibiting dexamethasone-induced apoptosis
IntroductionSteroid-induced osteonecrosis of the femoral head (SONFH) is a progressive and debilitating disorder caused by excessive glucocorticoid exposure. Dysfunction of bone marrow mesenchymal stem cells (BMSCs) and their exosome (Exos)-mediated signal transduction plays a key role in SONFH…
-
Artikel Jurnal
Synergistic photothermal therapy of esophageal cancer using Pt@MOF@PSs nanozymes
Globally, esophageal cancer (EC) is the seventh most commonly diagnosed cancer and the sixth leading cause of cancer-related death. However, its treatment remains challenging due to significant obstacles. Photothermal therapy (PTT), a minimally invasive technique, has emerged as a promising method…
-
Artikel Jurnal
Patient-specific 3D cryo(bio)printing of a glenoid labrum scaffold for fibrocartilaginous tissue engineering
The glenoid labrum is a fibrocartilaginous structure essential for shoulder stability, yet its regeneration remains an unmet clinical challenge. Current surgical approaches restore initial joint stability but frequently fail to reestablish native biomechanics, leading to recurrence and early…
-
Artikel Jurnal
Evaluation of DMSO-free cryopreservation reagent XT-Thrive for establishment of mesenchymal stem cell bank platform
IntroductionEffective cryopreservation is essential for the clinical application and large-scale banking of mesenchymal stem cells (MSCs). This study compares the performance of a novel DMSO-free cryoprotectant, XT-Thrive®, with a conventional DMSO-based solution, CryoStor® CS10, in preserving both…
-
Artikel Jurnal
Noninvasive prescreening of pediatric adenoid hypertrophy using quantified MFCC statistics and clinical features: development and external validation
BackgroundAdenoid hypertrophy (AH) is a leading cause of pediatric obstructive sleep apnea, yet first-line diagnostics are invasive or resource-intensive. We developed and externally tested a low-cost, noninvasive screening model that fuses quantitative voice features with routine clinical…
-
Artikel Jurnal
Application of nanoparticles in antibody drug delivery
Due to their special molecular weight and pharmacokinetic/pharmacodynamic (PK/PD) characteristics, antibody drugs have difficulty crossing the body barrier and entering complex microenvironments to provide effective treatment for encephalopathy, cancer, and severe infectious diseases. With the…
-
Artikel Jurnal
Cerium oxide nanoparticles for enhanced healing of diabetic foot ulcers
One of the main complications of diabetes is diabetic foot ulcers (DFUs), which have a substantial global impact on morbidity, medical expenses, and lower limb amputations. A complicated microenvironment—characterized by bacterial infections, chronic inflammation, oxidative stress, and poor…
Menampilkan maksimal 50 halaman. Persempit pencarian dengan filter untuk hasil yang lebih spesifik.