18 hasil untuk "Sachin Mathur"
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Artikel Jurnal
Systematic review of the efficacy of a hybrid operating theatre in the management of severe trauma
Abstract Background Hybrid operating theatres (OT) allow for simultaneous interventional radiology and operative procedures, serving as a one-stop facility for the treatment of severely injured patients. Several countries have adopted the use of the hybrid OT however their clinical impact in…
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Artikel Jurnal
Comprehensive geriatric assessment, frailty and sarcopenia in elderly surgical patients: a narrative review of evidence
Background: As the number of elderly undergoing surgical procedures increases with our aging population, the risk of adverse surgical outcomes also increases with reduced physiological reserve, multiple comorbidities, frailty and functional disability. Objectives: As Comprehensive Geriatric…
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Artikel Jurnal
Linguistic markers predict onset of Alzheimer's disease
Background: The aim of this study is to use classification methods to predict future onset of Alzheimer's disease in cognitively normal subjects through automated linguistic analysis. Methods: To study linguistic performance as an early biomarker of AD, we performed predictive modeling of future…
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Artikel Jurnal
A clinical predictive model for risk stratification of patients with severe acute lower gastrointestinal bleeding
Abstract Background Lower gastrointestinal bleeding (LGIB) is a common presentation of surgical admissions, imposing a significant burden on healthcare costs and resources. There is a paucity of standardised clinical predictive tools available for the initial assessment and risk stratification of…
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Artikel Jurnal
Prevalence of white matter hyperintensities and radiological cerebral small vessel disease: an insight from routinely collected data
Abstract Background Approximately 900,000 MRI brain scans are performed annually in the United Kingdom alone, with incidental findings frequently encountered. One of the most prevalent findings is white matter hyperintensities (WMHs). WMHs often indicate cerebral small vessel disease (cSVD) but can…
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Artikel Jurnal
Development of an algorithm for finding pertussis episodes in a population-based electronic health record database
While tetanus-diphtheria-acellular pertussis (Tdap) vaccines for adolescents and adults were licensed in 2005 and immunization strategies proposed, the burden of pertussis in this population remains under-recognized mainly due to atypical disease presentation, undermining efforts to optimize…
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Artikel Jurnal
Estimating the pertussis burden in adolescents and adults in the United States between 2007 and 2019
We developed a machine learning algorithm to identify undiagnosed pertussis episodes in adolescent and adult patients with reported acute respiratory disease (ARD) using clinician notes in an electronic healthcare record (EHR) database. Here, we utilized the algorithm to better estimate the overall…
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Artikel Jurnal
The interplay between diabetes Mellitus and soft tissue infections in general surgical patients
Abstract Background Diabetes mellitus (DM) is a worldwide pandemic affecting 500 million people. It is known to be associated with increased susceptibility to soft tissue infections (STI). Despite being a major public health burden, the literature relating the effects of DM and the presentation…
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Artikel Jurnal Teks lengkap
The Functional, Psychological and Economic Impacts 6 Months Post Major Trauma
Purpose The consequences of severe traumatic injury extend beyond hospital admission and have the potential for long-term functional, psychological, and economic sequalae. This study investigated patient outcomes 6 months following major trauma. Methods Using the National Trauma Registry, database…
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Artikel Jurnal
Pathophysiology, prevention and treatment of postoperative peritoneal adhesions: a WSES narrative
Abstract Background Adhesions are a common complication following surgery, and they can cause significant morbidity. However, adhesions are not easily diagnosed with imaging, and often only become apparent when they cause intestinal obstruction symptoms. The pathophysiology of adhesion formation is…
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Artikel Jurnal
Ten years of acute care surgery in Singapore: evolution, outcomes and future challenges
Abstract Background Acute Care Surgery (ACS) has emerged as a structured solution to challenges in emergency general surgery (EGS), including subspecialisation, fragmented coverage, and delays in operative care. Methods This narrative review outlines the global ACS evolution and examines…
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Artikel Jurnal
Oncology workload in a tertiary hospital during the COVID-19 pandemic
Introduction Workload in oncology during a pandemic is expected to increase as manpower is shunted to other areas of need in combating the pandemic. This increased workload, coupled with the high care needs of cancer patients, can have negative effects on both healthcare providers and their…
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Artikel Jurnal
Association of COVID-19 ‘circuit breaker’ with higher rates of elderly trauma admissions
Introduction: In December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) virus emerged and caused a worldwide pandemic, leading to measures being imposed by many countries to reduce its transmission. Singapore implemented the ‘circuit breaker’, which restricted all movements…
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Artikel Jurnal Teks lengkap
In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels
C5-substituted 2,4-diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS (DAQ-DcpSi) have been developed for the treatment of spinal muscular atrophy (SMA), which is caused by genetic deficiency in the Survival Motor Neuron (SMN) protein. These compounds are claimed to act as SMN2…
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Artikel Jurnal
Uncertainty and unmet needs in older high-risk blunt trauma survivors and their caregivers: a multi-centre mixed methods study
Abstract Quality-of-life is reduced in older patients surviving major blunt trauma. Pre-injury frailty, chronic illness, low falls, or head injury, increase the risk of unplanned healthcare utilization and post-discharge mortality. However, post-hospitalization needs and experiences of patients and…