19 hasil untuk "Samiran Ray"

मधुसूदनसरस्वतीविरचिते कृष्णकुतूहले काव्यसौन्दर्यविचारः

SAMIRAN RAY

Prachi Prajna, Vol. 5 No. IX · 2019 · DOAJ

संस्कृतसाहित्ये अङ्गुलीपर्वसु नर्तितनामधेयेषु कविपुङ्गवेषु भक्तवरेण्य: मधुसूदनसरस्वती सर्वदा मूर्धनि राजते इत्यत्र नास्ति मनागपि आरेक: । अद्वैतवेदान्ती मधुसूदनसरस्वती नैकेषां प्रसिद्धग्रथानां रचयिता । अस्य कृष्णकुतूहलम् इति नाटकं बिभर्ति किञ्चन माहात्म्यमिति कथने स्वल्पापि अतिशयोक्ति: न विद्यते इति…

Survey of Oxygen Delivery Practices in UK Paediatric Intensive Care Units

Sainath Raman; Samiran Ray; Mark J. Peters

Critical Care Research and Practice, Vol. 2016 · 2016 · Inggris · DOAJ Scopus

Purpose. Administration of supplemental oxygen is common in paediatric intensive care. We explored the current practice of oxygen administration using a case vignette in paediatric intensive care units (PICU) in the united kingdom. Methods. We conducted an online survey of Paediatric Intensive Care…

Arterial carboxyhaemoglobin levels in children admitted to PICU: A retrospective observational study

Ankur Chawla; Samiran Ray; Adela Matettore dkk.

PLOS ONE, Vol. 14 No. 3 · 2019 · Inggris · PLOS Scopus

While carbon monoxide (CO) is considered toxic, low levels of endogenously produced CO are protective against cellular injury induced by oxidative stress. Carboxyhaemoglobin (COHb) levels have been associated with outcomes in critically ill adults. We aimed to describe the distribution of…

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A physiologically constrained calibration framework for cardiovascular models applied to a paediatric synthetic sepsis population

Manuel T. Cabeleira; Samiran Ray; Nicholas C. Ovenden dkk.

PLOS Computational Biology, Vol. 22 No. 10 · 2026 · Inggris · PLOS Scopus

Calibration of mechanistic cardiovascular models is a central barrier to their use in population analysis and patient-specific simulation, particularly in settings where key physiological variables are unobservable and multiple parameter combinations can reproduce the same haemodynamic targets. In…

Transitions in intensive care: Investigating critical slowing down post extubation

Lucinda Khalil; Sandip V. George; Katherine L. Brown dkk.

PLOS ONE, Vol. 20 No. 1 · 2025 · Inggris · PLOS Scopus

Complex biological systems undergo sudden transitions in their state, which are often preceded by a critical slowing down of dynamics. This results in longer recovery times as systems approach transitions, quantified as an increase in measures such as the autocorrelation and variance. In this…

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Improved oxygenation following methylprednisolone therapy and survival in paediatric acute respiratory distress syndrome

Rebecca B. Mitting; Samiran Ray; Michael Raffles dkk.

PLOS ONE, Vol. 14 No. 11 · 2019 · Inggris · PLOS Scopus

Background: Methylprednisolone remains a commonly used ancillary therapy for paediatric acute respiratory distress syndrome (PARDS), despite a lack of level 1 evidence to justify its use. When planning prospective trials it is useful to define response to therapy and to identify if there is…

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Discovering patient groups in sequential electronic healthcare data using unsupervised representation learning

Jingteng Li; Kimberley R. Zakka; John Booth dkk.

BMC Medical Informatics and Decision Making, Vol. 25 No. 1 · 2025 · Inggris · DOAJ Scopus

Abstract Introduction Unsupervised feature learning methods inspired by natural language processing (NLP) models are capable of constructing patient-specific features from longitudinal Electronic Health Records (EHR). Design We applied document embedding algorithms to real-world paediatric…

Prediction cardiovascular deterioration in a paediatric intensive care unit (PicEWS): a machine learning modelling study of routinely collected health-care dataResearch in context

Dan Fredman Stein; Michael J. Carter; John Booth dkk.

EClinicalMedicine, Vol. 85 · 2025 · Inggris · DOAJ Scopus

Summary: Background: Paediatric intensive care medicine uses fine granular clinical data that describe substantial patient instability to make high-consequence decisions. However, these decisions are also hindered by clinical experts’ ability to interpret longitudinal data along with recent and…

Dual-phase machine learning framework for paediatric ventilator liberation: forecasting extubation readiness and nowcasting extubation outcomes

Padmanabhan Ramnarayan; Emma C Alexander; Samiran Ray dkk.

BMJ Digital Health & AI, Vol. 1 No. 1 · 2025 · Inggris · DOAJ

Objective To develop and validate a machine learning framework for predicting optimal extubation timing in paediatric intensive care units (PICUs), addressing the clinical need for continuous monitoring of weaning readiness and extubation safety.Methods and analysis We developed a dual-phase…

The Predictive Value of the NICE “Red Traffic Lights” in Acutely Ill Children

Evelien Kerkhof; Monica Lakhanpaul; Samiran Ray dkk.

PLoS ONE, Vol. 9 No. 3 · 2014 · Inggris · PLOS Scopus

Objective: Early recognition and treatment of febrile children with serious infections (SI) improves prognosis, however, early detection can be difficult. We aimed to validate the predictive rule-in value of the National Institute for Health and Clinical Excellence (NICE) most severe alarming signs…

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Neutrophil myeloperoxidase as a functional biomarker for RSV severity: implications for in vitro therapeutic screening

Machaela Palor; Tereza Masonou; Elisabeth J. Robinson dkk.

Nature Communications, Vol. 17 No. 1 · 2026 · Inggris · DOAJ Scopus

Abstract Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infections in infants, yet therapeutics are lacking. The aim of this study was to develop a pre‑clinical model that recapitulates key clinical outcomes in infants with RSV bronchiolitis, such as…

Conservative versus liberal oxygenation targets in critically ill children: the Oxy-PICU RCT

Doug Gould; Samiran Ray; Irene Chang dkk.

Health Technology Assessment, Vol. 30 No. 13 · 2026 · Inggris · DOAJ Scopus

Background The optimal target for systemic oxygenation in critically ill children is unknown. Liberal oxygenation is widely practised but is associated with harm in observational studies. Objectives To evaluate the clinical and cost-effectiveness of a conservative oxygenation target of peripheral…

Ketogenic diet therapy for children with super‐refractory status epilepticus in intensive care: International clinical practice recommendations

Robyn Blackford; Victoria J. Whiteley; Isobel Hardy dkk.

Epilepsia Open, Vol. 11 No. 4 · 2026 · Inggris · DOAJ Scopus

Abstract Objective We aimed to create practical recommendations to support healthcare teams starting ketogenic diet therapy (KDT) for children with super‐refractory status epilepticus in intensive care settings. Methods A literature review was conducted to extract published data on patient…

Permissive versus restrictive temperature thresholds in critically ill children with fever and infection: a multicentre randomized clinical pilot trial

Mark J. Peters; Kerry Woolfall; Imran Khan dkk.

Critical Care, Vol. 23 No. 1 · 2019 · Inggris · DOAJ Scopus

Abstract Background Fever improves pathogen control at a significant metabolic cost. No randomized clinical trials (RCT) have compared fever treatment thresholds in critically ill children. We performed a pilot RCT to determine whether a definitive trial of a permissive approach to fever in…

Stratified analyses refine association between TLR7 rare variants and severe COVID-19

Jannik Boos; Caspar I. van der Made; Gayatri Ramakrishnan dkk.

HGG Advances, Vol. 5 No. 4 · 2024 · Inggris · DOAJ Scopus

Summary: Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host genetic variants and their relation to other risk factors remains limited. Here, 52 genes with prior etiological evidence were sequenced in 1,772 severe COVID-19 cases and…