12 hasil untuk "Simone Bruno"

Stochastic modeling of epigenetic memory

Simone Bruno; Domitilla Del Vecchio

npj Systems Biology and Applications, Vol. 12 No. 1 · 2026 · Inggris · DOAJ Scopus

Abstract Here, we review mathematical models of epigenetic memory, focusing on chromatin modifications as key mechanisms to achieve long-term maintenance of epigenetic states. After reviewing the main stochastic modeling frameworks, we focus on stochastic models of chromatin modifications to…

Judith and Holofernes: Reconstructing the History of a Painting Attributed to Artemisia Gentileschi

Anna Impallaria; Ferruccio Petrucci; Simone Bruno

Heritage, Vol. 2 No. 3 · 2019 · Inggris · DOAJ Scopus

Recently, a new painting attributed to Artemisia Gentileschi was found in Ferrara, representing Judith exposing the head of Holofernes. Some analyses have been required to verify the history of this canvas, because another known painting is very similar to this one with the exception of the heads…

Epigenetic cell memory: The gene’s inner chromatin modification circuit

Simone Bruno; Ruth J. Williams; Domitilla Del Vecchio

PLOS Computational Biology, Vol. 18 No. 4 · 2022 · Inggris · PLOS Scopus

Epigenetic cell memory allows distinct gene expression patterns to persist in different cell types despite a common genotype. Although different patterns can be maintained by the concerted action of transcription factors (TFs), it was proposed that long-term persistence hinges on chromatin state…

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Epigenetic OCT4 regulatory network: stochastic analysis of cellular reprogramming

Simone Bruno; Thorsten M. Schlaeger; Domitilla Del Vecchio

npj Systems Biology and Applications, Vol. 10 No. 1 · 2024 · Inggris · DOAJ Scopus

Abstract Experimental studies have shown that chromatin modifiers have a critical effect on cellular reprogramming, i.e., the conversion of differentiated cells to pluripotent stem cells. Here, we develop a model of the OCT4 gene regulatory network that includes genes expressing chromatin modifiers…

Computational Studies of the Photogeneration from Dihydrosanguinarine and the Probable Cytotoxicity Mechanism of Sanguinarine

Stefano Scoditti; Simone Bruno; Emilia Sicilia dkk.

Applied Sciences, Vol. 12 No. 3 · 2022 · Inggris · DOAJ Scopus

A computational investigation of the mechanism of dihydrosanguinarine (DHSAN) photoactivation and its conversion into the active drug sanguinarine (SAN) is here reported. The reaction mechanism of DHSAN photoconversion was fully explored by considering its excitation first, essential for generating…

Bipolar disorder and delayed sleep-wake phase disorder: Findings on sustained attention, sleep, and circadian rhythm parameters

Francy Cruz-Sanabria; Leonardo Massoni; Miriam Violi dkk.

Journal of Affective Disorders Reports, Vol. 14 · 2023 · Inggris · DOAJ Scopus

Background: Sleep and circadian rhythm disruptions can contribute to cognitive disturbances in bipolar disorder (BD); however, the profile of specific sleep/circadian phenotypes remains to be elucidated. The aim of our work is to compare sleep/circadian parameters and sustained attention between…

Archaeometric Investigations on Archaeological Findings from Palazzo Corsini Alla Lungara (Rome)

Tilde de Caro; Fiammetta Susanna; Paola Fraiegari dkk.

Ceramics, Vol. 7 No. 1 · 2024 · Inggris · DOAJ Scopus

This study reports the analytical investigations on clayey and ceramic finds, characterised by high variability in terms of prime materials, with the aim to determine the role of this important ceramic production situated close to the city walls, fortuitously found during service excavations…

Analog epigenetic memory revealed by targeted chromatin editing

Sebastian Palacios; Simone Bruno; Ron Weiss dkk.

Cell Genomics, Vol. 5 No. 11 · 2025 · Inggris · DOAJ Scopus

Summary: Cells store information by means of chromatin modifications that persist through cell divisions and can hold gene expression silenced over generations. However, how these modifications may maintain other gene expression states has remained unclear. This study shows that chromatin…

Urban Water Management in Milan Metropolitan Area, a review

Davide Sartirana; Chiara Zanotti; Marco Rotiroti dkk.

Acque Sotterranee, Vol. 13 No. 3 · 2024 · Italia · DOAJ Scopus

The increasing rate of urbanisation and extreme climatic events represent a constant threat for urban water resources management. In recent decades, Milan Metropolitan Area (Lombardy Region, Northern Italy) has been affected by a) frequent extreme rainfall events, responsible for the flooding of…

A fieldable process for sensitive detection of airborne viruses via electrophoresis-based RNA enrichment

Huifeng Du; Simone Bruno; Kalon J. Overholt dkk.

Biosensors and Bioelectronics: X, Vol. 19 · 2024 · Inggris · DOAJ Scopus

Sensitive on-site virus detection is a requirement for timely action against the spread of airborne infection since ultra-low in-air viral concentrations can readily infect individuals when inhaled. Here, we consider a fieldable biosensing process that incorporates a fast RNA enrichment step in…

Targeted degradation of MDM2 overcomes feedback regulation of p53 signaling in Merkel cell carcinoma models

Varsha Ananthapadmanabhan; Simone Bruno; Leonard Vonk dkk.

The Journal of Clinical Investigation, Vol. 136 No. 13 · 2026 · Inggris · DOAJ Scopus

MDM2 is transcriptionally activated by the ST-MYCL-Tip60 complex in virus-positive Merkel cell carcinoma (MCC). MDM2 suppresses p53 and is a rational therapeutic target. MDM2 inhibitors face an intrinsic limitation: p53 activation induces MDM2 transcription, creating a feedback loop that blunts…