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Cell Genomics
Scopus
ISSN 2666-979X · Elsevier · 399 artikel di indeks
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Artikel Jurnal
The dimmer switch in epigenetics: How DNA methylation encodes gene activity over time
Can individual cells retain a memory of past gene expression levels even after the stimulus has faded? In this issue of Cell Genomics, Domitilla Del Vecchio and colleagues describe an analog epigenetic memory system in which DNA methylation acts as a signal that locks in gene expression levels over…
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Artikel Jurnal
The gut’s hidden arsenal: A genomics-guided atlas of class II bacteriocins
Unmodified class II bacteriocins promise precision antimicrobials that spare bystander microbes. Zhang and colleagues introduce IIBacFinder, a genomics-guided pipeline that detects precursor and context genes with a curated pHMM library, infers leader-peptide cleavage, and triages candidates by…
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Artikel Jurnal
Decoding missense variants pleiotropy in the immune GPCR P2RY8
G protein-coupled receptors (GPCRs) form the largest family of cell surface receptors and remain a central focus in pharmacology and drug discovery. Despite extensive structural and pharmacological studies, the functional impact of missense variation across GPCRs remains poorly understood…
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Artikel Jurnal
Hominoid-specific retrotransposons fuel regulatory novelty in early brain development
Transposable elements can drive genetic innovation. In this issue of Cell Genomics, Adami et al.1 investigate the impact of hominoid-specific L1 retrotransposons on early embryonic and brain development. Using induced pluripotent stem cells and cerebral organoid models, multi-omics, and…
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Artikel Jurnal
Genetic history and adaptation of Eurasian wild boars inform livestock breeding
Historical expansions of wild boars (Sus scrofa) across Eurasia have shaped phenotypic variation, genetic diversity, and local adaptation of their populations. The study by Wang et al.1 investigates the demographic history and genetic adaptation of Eurasian wild boars based on 96 whole-genome…
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Galaxy single-cell & spatial omics community update: Navigating new frontiers in 2025
Summary: Single-cell omics, named Method of the Year three times, have revolutionized biological research by enabling the high-resolution exploration of cellular heterogeneity and molecular processes. Initially centered on transcriptomics, this rapidly evolving field now ranges from multiomics to…
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Artikel Jurnal
Ternary-code DNA methylation dynamics: A new era for scalable mapping
The preview discusses the scalable platform for methylation-based trait mapping published in Cell Genomics by Goldberg et al.1 This work represents not only a methodological advance but also marks a conceptual shift toward scalable and high-throughput functional, targeted, and context-sensitive…
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Artikel Jurnal
Network-based drug repurposing for psychiatric disorders using single-cell genomics
Summary: Neuropsychiatric disorders lack effective treatments due to a limited understanding of the underlying cellular and molecular mechanisms. To address this, we integrated population-scale single-cell genomics data and analyzed 23 cell-type-level gene regulatory networks across schizophrenia…
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Artikel Jurnal
Identification of novel type 1 and type 2 diabetes genes by co-localization of human islet eQTL and GWAS variants with colocRedRibbon
Summary: Over 1,000 genetic variants have been associated with diabetes by genome-wide association studies (GWASs), but for most, their functional impact is unknown; only 7% alter gene expression in pancreatic islets in expression quantitative trait locus (eQTL) studies. To fill this gap, we…
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Artikel Jurnal
3D chromatin structures precede genome activation in Drosophila embryogenesis
Summary: 3D chromatin structure is critical for the regulation of gene expression during development. Here we used Micro-C assays at 100-bp resolution to map genome organization in Drosophila melanogaster throughout the first half of embryogenesis. These high-resolution contact maps reveal…
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Artikel Jurnal
A peptide display system identifies a potent mutant β-melanocyte-stimulating hormone agonist of melanocortin-4 receptor
Summary: Non-olfactory G-protein-coupled receptors (GPCRs) regulate vital physiological functions and are targets for ∼34% of US Food and Drug Administration (FDA)-approved drugs. While small-molecule-activated GPCRs are well studied, there is growing interest in peptide GPCRs, particularly the…
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Artikel Jurnal
Cell-type-specific dysregulation of gene expression due to Chd8 haploinsufficiency during mouse cortical development
Summary: Disruptive variants in the chromodomain helicase CHD8 are associated with risk for autism spectrum disorder (ASD). CHD8 haploinsufficiency is hypothesized to contribute to ASD by perturbing neurodevelopmental gene expression. However, insight into cell-type-specific transcriptional effects…
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Artikel Jurnal
Analog epigenetic memory revealed by targeted chromatin editing
Summary: Cells store information by means of chromatin modifications that persist through cell divisions and can hold gene expression silenced over generations. However, how these modifications may maintain other gene expression states has remained unclear. This study shows that chromatin…
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Artikel Jurnal
Systematically investigating and identifying bacteriocins in the human gut microbiome
Summary: Human gut microbiota produces unmodified bacteriocins, natural antimicrobial peptides that protect against pathogens and regulate host physiology. However, current bioinformatic tools limit the comprehensive investigation of bacteriocins’ biosynthesis, obstructing research into their…
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Artikel Jurnal
Sensitive dissection of a genomic regulatory landscape using bulk and targeted single-cell activation
Summary: Enhancers are known to spatiotemporally regulate gene transcription, yet the identification of enhancers and their target genes is often indirect, low resolution, and/or assumptive. To identify and functionally perturb enhancers at their endogenous sites, we performed a pooled tiling…
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Artikel Jurnal
Endogenous fine-mapping and prioritization of functional regulatory elements in complex genetic loci
Summary: Most genetic loci linked to polygenic traits are in non-coding regions, with complex regulation and linkage disequilibrium (LD), complicating causal variant and gene prioritization. We used multiplexed single-cell CRISPR interference and activation perturbations to investigate…
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Artikel Jurnal
Phenotypic pleiotropy of missense variants in human B cell confinement receptor P2RY8
Summary: Missense variants can have pleiotropic effects on protein function, and predicting these effects can be difficult. We performed near-saturation deep mutational scanning of P2RY8, a G protein-coupled receptor that promotes germinal center B cell confinement. We assayed the effect of each…
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Artikel Jurnal
LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development
Summary: Long interspersed nuclear element 1 (L1) retrotransposons represent a vast source of genetic variability. However, mechanistic analysis of whether and how L1s contribute to human developmental programs is lacking, in part due to the challenges associated with specific profiling and…
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Artikel Jurnal
Single-cell analysis of Barrett’s esophagus and carcinoma reveals cell types conferring risk via genetic predisposition
Summary: Inherited genetic variants contribute to Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC), but it is unknown which cell types are involved in this process. We performed single-cell RNA sequencing of BE, EAC, and paired normal tissues and integrated genome-wide association data…
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Artikel Jurnal
Structural variation, selection, and diversification of the NPIP gene family from the human pangenome
Summary: The NPIP gene family is among the most positively selected gene families in humans/apes and drives independent duplication in primate lineages. These duplications promote genetic instability, leading to recurrent disease-associated microduplication and microdeletion syndromes. Despite its…