48 results for "Simran"
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Wading through Molasses: A qualitative examination of the experiences, perceptions, attitudes, and knowledge of Australian medical practitioners regarding medical billing
Background: Medical billing errors and fraud have been described as one of the last “great unreduced healthcare costs,” with some commentators suggesting measurable average losses from this phenomenon are 7% of total health expenditure. In Australia, it has been estimated that leakage from Medicare…
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Neurally-constrained modeling of human gaze strategies in a change blindness task
Despite possessing the capacity for selective attention, we often fail to notice the obvious. We investigated participants’ (n = 39) failures to detect salient changes in a change blindness experiment. Surprisingly, change detection success varied by over two-fold across participants. These…
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Reported clinical breast examination activity in Bangladesh, 2019–2025: Temporal trends, geographic variation, positivity, and reporting completeness
Background: Routine clinical breast examination (CBE) services contribute to breast cancer early-detection activities in Bangladesh, but national program performance and reporting completeness are poorly characterized. We assessed reported CBE activity, geographic variation, positivity, reporting…
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Mechanistic Insights into the Antilithiatic Proteins from Terminalia arjuna : A Proteomic Approach in Urolithiasis
Kidney stone formation during hyperoxaluric condition is inherently dependent on the interaction between renal epithelial cells and calcium oxalate (CaOx) crystals. Although modern medicine has progressed in terms of removal of these stones, recurrence and persistent side effects restricts their…
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How does feedback from phage infections influence the evolution of phase variation in Campylobacter ?
Campylobacter jejuni (C. jejuni) causes gastroenteritis following the consumption of contaminated poultry meat, resulting in a large health and economic burden worldwide. Phage therapy is a promising technique for eradicating C. jejuni from poultry flocks and chicken carcasses. However, C. jejuni…
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High-resolution ex vivo nanoCT reveals 3D architecture of the adult male mouse lower urogenital tract
Benign prostatic hyperplasia (BPH) is the most common cause of lower urinary tract symptoms/dysfunction (LUTS/LUTD) in aging men. Over the past 30 years, the prevalence of BPH has increased by 122%, rising from 50.7 million cases in 1990 to 112.5 million in 2021. It is expected that this number…
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Evaluation of Amoebicidal Potential of Paneth Cell Cryptdin-2 against Entamoeba histolytica
Background: Amoebiasis is a major public health problem in tropical and subtropical countries. Currently, metronidazole is the gold choice medication for the treatment of this disease. However, reports have indicated towards the possibility of development of metronidazole-resistance in Entamoeba…
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Changes in individuals’ glaucoma progression velocity after IOP-lowering therapy: A systematic review
Primary open-angle glaucoma (POAG) is a chronic progressive optic neuropathy often associated with increased intraocular pressure (IOP). Monitoring glaucoma progression velocity, for example, the rate of change in global indices such as mean deviation (MD), is a common way to determine whether…
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Microarray Analyses of Glucocorticoid and Vitamin D3 Target Genes in Differentiating Cultured Human Podocytes
Glomerular podocytes are highly differentiated epithelial cells that are key components of the kidney filtration units. Podocyte damage or loss is the hallmark of nephritic diseases characterized by severe proteinuria. Recent studies implicate that hormones including glucocorticoids (ligand for…
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Experiences of postpartum anxiety during the COVID-19 pandemic: A mixed methods study and demographic analysis
Introduction: The first wave of the COVID-19 pandemic saw the reconfiguration of perinatal and maternity services, national lockdowns, and social distancing measures which affected the perinatal experiences of new and expectant parents. This study aimed to explore the occurrence of postpartum…
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Peeping into Human Renal Calcium Oxalate Stone Matrix: Characterization of Novel Proteins Involved in the Intricate Mechanism of Urolithiasis
Background: The increasing number of patients suffering from urolithiasis represents one of the major challenges which nephrologists face worldwide today. For enhancing therapeutic outcomes of this disease, the pathogenic basis for the formation of renal stones is the need of hour. Proteins are…
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Sp100 colocalizes with HPV replication foci and restricts the productive stage of the infectious cycle
We have shown previously that Sp100 (a component of the ND10 nuclear body) represses transcription, replication and establishment of incoming human papillomavirus (HPV) DNA in the early stages of infection. In this follow up study, we show that Sp100 does not substantially regulate viral infection…
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Response surface methodology based extraction of Tribulus terrestris leads to an upsurge of antilithiatic potential by inhibition of calcium oxalate crystallization processes
Tribulus terrestris has significant antilithiatic efficacy established via both in vitro as well as in vivo studies and is used in numerous anti-urolithiatic herbal formulations viz. Cystone, Uriflow, Uritone and Neeri. However, to fully utilize its antilithiatic potential, the influence of…
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Inhibition of Host Vacuolar H + -ATPase Activity by a Legionella pneumophila Effector
Legionella pneumophila is an intracellular pathogen responsible for Legionnaires' disease. This bacterium uses the Dot/Icm type IV secretion system to inject a large number of bacterial proteins into host cells to facilitate the biogenesis of a phagosome permissive for its intracellular growth…
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Comprehensive Identification of Protein Substrates of the Dot/Icm Type IV Transporter of Legionella pneumophila
A large number of proteins transferred by the Legionella pneumophila Dot/Icm system have been identified by various strategies. With no exceptions, these strategies are based on one or more characteristics associated with the tested proteins. Given the high level of diversity exhibited by the…
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The first darter (Aves: Anhingidae) fossils from India (late Pliocene)
New fossils from the latest Pliocene portion of the Tatrot Formation exposed in the Siwalik Hills of northern India represent the first fossil record of a darter (Anhingidae) from India. The darter fossils possibly represent a new species, but the limited information on the fossil record of this…
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Human IgG3 with extended half-life does not improve Fc-gamma receptor-mediated cancer antibody therapies in mice
Background: Current anti-cancer therapeutic antibodies that are used in the clinic are predominantly humanized or fully human immunoglobulin G1 (IgG1). These antibodies bind with high affinity to the target antigen and are efficient in activating the immune system via IgG Fc receptors and/or…
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Utility of enhanced recovery after surgery protocols in reducing postoperative opioid use across different surgical specialties—An analysis of Iowa’s billion pill pledge program
Introduction: The opioid epidemic in the United States poses a major public health challenge, particularly in the context of surgery and perioperative pain management. This study examines the effectiveness of the “Billion Pill Pledge” Enhanced Recovery After Surgery (ERAS) protocols implemented…
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Highly Adaptable Triple-Negative Breast Cancer Cells as a Functional Model for Testing Anticancer Agents
A major obstacle in developing effective therapies against solid tumors stems from an inability to adequately model the rare subpopulation of panresistant cancer cells that may often drive the disease. We describe a strategy for optimally modeling highly abnormal and highly adaptable human…