10 hasil untuk "Su, Lin"

Multiple myeloma: Combination therapy of BET proteolysis targeting chimeric molecule with CDK9 inhibitor

Su-Lin Lim; Liang Xu; Bing-Chen Han dkk.

PLOS ONE, Vol. 15 No. 6 · 2020 · Inggris · PLOS Scopus

Cyclin Dependent Kinase 9 (CDK9) associates with Bromodomain and Extra-Terminal Domain (BET) proteins to promote transcriptional elongation by phosphorylation of serine 2 of RNAP II C-terminal domain. We examined the therapeutic potential of selective CDK9 inhibitors (AZD 4573 and MC180295) against…

Delayed correlation between the incidence rate of indigenous murine typhus in humans and the seropositive rate of Rickettsia typhi infection in small mammals in Taiwan from 2007–2019

Pai-Shan Chiang; Shin-Wei Su; Su-Lin Yang dkk.

PLOS Neglected Tropical Diseases, Vol. 16 No. 4 · 2022 · Inggris · PLOS Scopus

Murine typhus is a flea-borne zoonotic disease with acute febrile illness caused by Rickettsia typhi and is distributed widely throughout the world, particularly in port cities and coastal regions. We observed that murine typhus was an endemic disease (number of annual indigenous cases =…

Epidemiology of human RSV in Taiwan, 2018–2024

Su-Lin Yang; Ming-Tsan Liu; Hsin-Hui Huang dkk.

PLOS One, Vol. 21 No. 9 · 2026 · Inggris · PLOS Scopus

Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections in infants and older adults worldwide. This retrospective study investigated the epidemiology and molecular characteristics of RSV in Taiwan from 2018 to 2024 using data from the National Community Virus…

Functional Role of mTORC2 versus Integrin-Linked Kinase in Mediating Ser473-Akt Phosphorylation in PTEN-Negative Prostate and Breast Cancer Cell Lines

Su-Lin Lee; Chih-Chien Chou; Hsiao-Ching Chuang dkk.

PLoS ONE, Vol. 8 No. 6 · 2013 · Inggris · PLOS Scopus

Although the rictor-mTOR complex (mTORC2) has been shown to act as phosphoinositide-dependent kinase (PDK)2 in many cell types, other kinases have also been implicated in mediating Ser473-Akt phosphorylation. Here, we demonstrated the cell line specificity of integrin-linked kinase (ILK) versus…

Risk Factors for Hospital Readmission after Radical Gastrectomy for Gastric Cancer: A Prospective Study

Cheng-Le Zhuang; Su-Lin Wang; Dong-Dong Huang dkk.

PLOS ONE, Vol. 10 No. 4 · 2015 · Inggris · PLOS Scopus

Background: Hospital readmission is gathering increasing attention as a measure of health care quality and a potential cost-saving target. The purpose of this prospective study was to determine risk factors for readmission within 30 days of discharge after gastrectomy for patients with gastric…

Molecular characterization and phylogenetic analysis of dengue viruses imported into Taiwan during 2011-2016

Cheng-Fen Yang; Shu-Fen Chang; Tung-Chien Hsu dkk.

PLOS Neglected Tropical Diseases, Vol. 12 No. 9 · 2018 · Inggris · PLOS Scopus

A total of 1,596 laboratory-confirmed imported dengue cases were identified in Taiwan during 2011–2016. Most of the imported cases arrived from Southeast Asia as well as the Indian subcontinent, the Pacific region, Latin America, Australia and Africa. Phylogenetic analyses of the complete envelope…

Serum Ceruloplasmin Levels Correlate Negatively with Liver Fibrosis in Males with Chronic Hepatitis B: A New Noninvasive Model for Predicting Liver Fibrosis in HBV-Related Liver Disease

Da-Wu Zeng; Yu-Rui Liu; Jie-Min Zhang dkk.

PLoS ONE, Vol. 8 No. 10 · 2013 · Inggris · PLOS Scopus

Aims: This study aimed to investigate associations between ceruloplasmin (CP) levels, inflammation grade and fibrosis stages in patients with chronic hepatitis B (CHB) and to establish a noninvasive model to predict cirrhosis. Methods: Liver biopsy samples and sera were collected from 198 CHB…

Molecular epidemiology of scrub typhus in Taiwan during 2006–2016

Hsiang-Fei Chen; Shih-Huan Peng; Kun-Hsien Tsai dkk.

PLOS Neglected Tropical Diseases, Vol. 16 No. 4 · 2022 · Inggris · PLOS Scopus

Scrub typhus is the most common endemic vector-borne disease in Taiwan. We identified a total of 4,857 laboratory-confirmed cases during 2006–2016 with hyperendemic foci on offshore islands, including Penghu (778 cases, 16.0%) and Kinmen (716 cases, 14.7%), and eastern Taiwan, including Taitung…

Correction: Molecular epidemiology of scrub typhus in Taiwan during 2006–2016

Hsiang-Fei Chen; Shih-Huan Peng; Kun-Hsien Tsai dkk.

PLOS Neglected Tropical Diseases, Vol. 16 No. 12 · 2022 · Inggris · PLOS Scopus

Pediatric melioidosis in Sarawak, Malaysia: Epidemiological, clinical and microbiological characteristics

Anand Mohan; Yuwana Podin; Nickson Tai dkk.

PLOS Neglected Tropical Diseases, Vol. 11 No. 6 · 2017 · Inggris · PLOS Scopus

Background: Melioidosis is a serious, and potentially fatal community-acquired infection endemic to northern Australia and Southeast Asia, including Sarawak, Malaysia. The disease, caused by the usually intrinsically aminoglycoside-resistant Burkholderia pseudomallei, most commonly affects adults…