19 hasil untuk "Syed Muhammad Saad"
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Artikel Jurnal
Analyzing the Convoluted Kashmir Dispute: A Retrospective Analysis
Kashmir is undoubtedly one of the most beautiful places on the globe. However, it is also considered one of the most dangerous places as well due to the protracted Kashmir dispute between two nuclear-capable neighboring powers, India and Pakistan. The dispute emerged after the questionable…
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Artikel Jurnal
Sandwich Generation in Contemporary Indonesia: Determining Responsibility in Caring for Elderly under Islamic Law and Positive Law
…has actually existed for a long time, even in the era of Prophet Muhammad SAW. The concept of sandwich generation can be interpreted the same as the concept of birrul walidain or devoted to parents. Of course, the concept of birrul walidain is a practice that is highly recommended to be done for…
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Artikel Jurnal
Ethyl (E)-3-(6-methyl-4-oxo-4H-chromen-3-yl)prop-2-enoate
In the title compound, C15H14O4, the chromone ring system is close to being planar [maximum deviation = 0.015 (2) Å]. The double bond of the ethyl prop-2-enoate chain adopts an E conformation and an intramolecular C—H...O hydrogen bond generates an S6 ring. In the crystal…
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Artikel Jurnal
N-(2,5-Dimethoxyphenyl)-6-nitroquinazolin-4-amine
In the title molecule, C16H14N4O4, the quinazoline ring is substantially planar (r.m.s. deviation = 0.0129 Å) and forms a dihedral angle of 2.73 (8)° with the benzene ring. The conformation of the molecule is stabilized by an intramolecular C—H...N hydrogen bond. In the crystal, molecules are…
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Artikel Jurnal
6-Methyl-4-oxo-4H-chromene-3-carbaldehyde
In the title compound, C11H8O3, the benzopyran-4-one or chromone ring system is almost planar, with a maximum deviation of 0.045 (2) Å. The crystal structure is stablized by π–π interactions between the benzene and pyran rings of inversion-related molecules stacked…
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Artikel Jurnal
N′-(3-Chlorobenzylidene)-4-hydroxybenzohydrazide
The molecule of the title compound, C14H11ClN2O2 adopts an E conformation of the azomethine double bond and the dihedral angle between the benzene rings is 38.96 (13)°. In the crystal, molecules are linked by N—H...O and O—H...O (with the ketone O atom as acceptor) and…
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Artikel Jurnal Teks lengkap
Thymidine phosphorylase and prostrate cancer cell proliferation inhibitory activities of synthetic 4-hydroxybenzohydrazides: In vitro , kinetic, and in silico studies
Over-expression of thymidine phosphorylase (TP) plays a key role in many pathological complications, including angiogenesis which leads to cancer cells proliferation. Thus in search of new anticancer agents, a series of 4-hydroxybenzohydrazides (1–29) was synthesized, and evaluated for in vitro…
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The role of Wnt signaling pathway in carcinogenesis and implications for anticancer therapeutics
The Wnt proteins are a family of 19 secreted glycoproteins that occupy crucial roles in the regulation of processes such as cell survival, proliferation, migration and polarity, cell fate specification, body axis patterning and self-renewal in stem cells. The canonical pathway has been implicated…
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Artikel Jurnal
Facile CuCl2·2H2O catalyzed one-pot conversion of dimedone into highly functionalized indazole based N-arylhydrazinecarbothioamides
A convenient and facile CuCl2·2H2O catalyzed one-pot synthetic strategy was designed for the conversion of readily available dimedone into highly functionalized N-arylhydrazinecarbothioamide based indazole derivatives. The product yields were found to be moderate to good without purification…
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Artikel Jurnal
2-{[(Dimethylamino)methylidene]amino}-5-nitrobenzonitrile
The title molecule, C10H10N4O2, is almost planar and adopts an E configuration of the azomethine [C=N = 1.298 (2) Å] double bond. The benzene ring is attached to an essentially planar (r.m.s. deviation = 0.0226 Å) amidine moiety (N=CN/Me2), the dihedral angle between the two mean planes being 18.42…
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Artikel Jurnal
Effects of home-based exercise program on physical functioning of hemodialysis patients: A randomized controlled trial
Chronic kidney disease is one of the leading causes of death, which is often neglected due to lack of knowledge and resources. The objective of this study was to determine the effects of home-based exercise on physical functioning, quality of life and fatigue assessment for patients on…
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MitraClip to the Rescue in Cardiogenic Shock: Case Series from a Single Center
Cardiogenic shock (CS) in the setting of acute coronary syndrome carries detrimental consequences and high levels of mortality and morbidity if not managed promptly. Acute mitral regurgitation (MR) as a complication of the myocardial infarction might superimpose refractory CS that warrants mitral…
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Uric Acid Lowering Effect of Thymoquinone in Potassium Oxonate-Induced Hyperuricemic Rats
Background: High serum uric acid levels lead to hyperuricemia, which, if left untreated, can result in gout, metabolic syndrome and can also be an aggravating factor in renal and cardiovascular conditions. Nowadays xanthine oxidase inhibitors and uricosuric drugs are used to treat hyperuricemia…
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Artikel Jurnal
In vitro antiglycation and antioxidant properties of benzophenone thiosemicarbazones
Fifteen benzophenone thiosemicarbazones were synthesized and their in vitro antiglycation activity was evaluated. The most active compound 2 (IC50 = 118.15±2.41μM) showed two folds potent activity than the standard, rutin (IC50 = 294.5±1.5μM). Compounds 1 and 3-7 showed good to moderate…
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Artikel Jurnal
Accurate determination of Biotinidase activity in serum by HPLC and its utilization as second tier test for the confirmation of initial positive newborn screening results
Diagnosis of Biotinidase deficiency (BTD) is extremely important to avoid several neurodevelopmental problems in early childhood. Colorimetric and fluorometric methods lack specificity and selectivity due to several interferences resulting in a high number of false positive results. We developed an…
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The efficacy and effectiveness of the COVID-19 vaccines in reducing infection, severity, hospitalization, and mortality: a systematic review
With the relatively rapid development of the COVID-19 pandemic, vaccine development has become crucial for limiting disease transmission. The accelerated growth in the approved COVID-19 vaccines has sparked concerns about their efficacies which have been assessed by many studies. This systematic…
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