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Pakistan Journal of Pharmaceutical Sciences
Scopus
ISSN 1011-601X · University of Karachi · 1,816 articles in the index
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Journal Article
Corrigendum to: Bone marrow mesenchymal stem cells relieve rheumatoid arthritis by blocking JAK/STAT and TLR-4/NF-κB pathways
The authors have informed the Pakistan Journal of Pharmaceutical Sciences (PJPS) of an error in Figure 5 of the published article. During the editorial revision process, an incorrect version of Figure 5 was inadvertently included in the final published version. The authors have confirmed that the…
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Journal Article
Corrigendum to: An in vitro method to study pancreatic acinar cells and centroacinar cells: Co-culture of rat pancreatic acinar cells AR42J and human pancreatic ductal epithelial cells HPDE6-C7
The authors request to change the acknowledgment statement section because of mistake in the statement. The correct acknowledgment is mentioned in the text below: “The present study was funded by the joint project on Regional High Incidence Diseases Research of Guangxi Natural Sciences Foundation…
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Journal Article
RETRACTED ARTICLE: Preparation of smart PVP/HPMC based IPN hydrogel, its characterization and toxicity evaluation
Following a complaint and technical (editorial) investigation, the authors were requested to provide essential documentation to verify the reliability, validity, and ethical compliance of the study published. Despite repeated reminders, the required documentation was not provided. Specifically, the…
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Journal Article
Anti-inflammatory agents after hip and shoulder arthroplasty: A systematic review and meta-analysis
Background: Postoperative inflammation after arthroplasty contributes to pain, delayed mobilization and prolonged hospitalization. Recent randomized trials have evaluated pharmacological anti-inflammatory strategies within contemporary enhanced recovery pathways, but evidence after hip and shoulder…
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Journal Article
LncRNA PVT1 in bone marrow mesenchymal stem cells suppresses prostate cancer progression via targeting miR-122 in tumor microenvironment
Background: Prostate cancer progression is influenced by the tumor microenvironment. Bone marrow mesenchymal stem cells (BMSCs) can modulate tumor behavior, but the role of their lncRNA PVT1 is unclear. Objective: To investigate whether lncRNA PVT1 in BMSCs regulates the malignant phenotype of…
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Journal Article
ATI-2341 TFA promotes acquisition of epithelial-like immunophenotype in bone marrow mesenchymal stem cells and alleviates intrauterine adhesion in a rat model
Background: Intrauterine adhesion (IUA) is a common complication of endometrial injury. Bone marrow mesenchymal stem cells (BMSCs) have been implicated in endometrial repair, but strategies to enhance their therapeutic efficacy remain to be optimized. The C-X-C chemokine receptor type 4…
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Journal Article
Therapeutic drug monitoring-guided individualized caffeine dosing for apnea of prematurity: Clinical efficacy and association with early neurobehavioral outcomes in preterm infants
Background: Given the high incidence of apnea of prematurity (AOP) and the repeated hypoxia-induced nerve damage, treatment optimization from the dosing perspective is critical. Caffeine is the current first-line therapeutic drug for AOP. However, the conventional dose results in low blood…
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Journal Article
Effect of Chinese medicine compound on intestinal bifidobacteria recovery and CD4+ T-Cell activation in postoperative chemotherapy patients with breast cancer
Background: Postoperative chemotherapy for breast cancer often leads to intestinal dysbiosis and immune suppression. Traditional Chinese medicine shows potential in regulating gut microbiota and enhancing immune function, offering a promising adjunctive therapeutic strategy. Objectives: To explore…
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Compound Miao medicine Jiuxian Luohan bone-setting decoction improves rat femoral fracture healing: Associations with osteogenic and apoptosis-related markers
Background: Fracture healing is a dynamic biological process involving inflammation, callus formation, mineralization and remodeling. Osteogenic and apoptosis-related markers may reflect changes during repair, but tissue-level marker expression alone does not establish a causal apoptotic mechanism…
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Journal Article
Mechanistic and translational perspectives on the regulation of macrophage functional states by astragalus polysaccharides
Macrophage functional states are increasingly viewed as a dynamic spectrum rather than a fixed M1/M2 dichotomy. Astragalus polysaccharides (APS) are structurally heterogeneous natural polysaccharides with reported immunomodulatory, anti-inflammatory, antioxidant, antitumor and tissue-repair…
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Journal Article
Polydopamine nanoparticles carrying bergenin inhibit the malignant biological behavior of glioma through inhibiting the CASC11/AKT3 axis
Background: Bergenin (BN), a C-glucoside of 4-O-methyl gallic acid, exhibits a broad spectrum of pharmacological activities, including notable antioxidant, anti-inflammatory and anticancer effects. Objectives: This study aimed to explore the impact of polydopamine nanoparticles loaded with bergenin…
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Journal Article
Madecassic acid attenuates sepsis-associated acute lung injury by regulating the PI3K/AKT/mTOR pathway to mediate anti-inflammatory, antioxidant and anti-apoptotic effects
Background: Sepsis-induced acute lung injury (ALI) is a critical illness with a high mortality rate. Madecassic acid (MA), a pentacyclic triterpenoid extracted from Centella asiatica, exhibits multiple biological activities, but its role in sepsis-associated ALI remains poorly elucidated…
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Journal Article
Improved transcutaneous delivery of cetirizine hydrochloride for the treatment of post-chemotherapy alopecia: Poke and emulgel approach
Background: Chemotherapy-induced alopecia negatively impacts the mental health of cancer patients. Topical minoxidil, a widely recommended drug for hair regrowth, causes scalp irritation and contact dermatitis. Oral minoxidil causes multiple cardiovascular and neurological side effects. Cetirizine…
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Journal Article
Dynamic evolution and industry trend analysis of China's pharmaceutical industry science and technology innovation network: A bibliometric approach
Background: The pharmaceutical industry is a strategic emerging sector in China, yet its scientific and technological innovation network remains poorly characterized in terms of structural dynamics and evolutionary pathways. Objectives: In the field of scientific and technological innovation in…
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Journal Article
Ultrasound-guided high-voltage vs conventional pulsed radiofrequency in elderly cervical radiculopathy: A randomized controlled trial
Background: Elderly patients with cervical radiculopathy present therapeutic challenges owing to comorbidities and medication-related risks. Long-term pharmacotherapy and surgical interventions are often suboptimal, necessitating evaluation of optimized pulsed radiofrequency strategies under image…
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Journal Article
Unveiling AKT1 as a key target of β-asarone in Alzheimer’s disease through network pharmacology and molecular dynamics simulations
Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by cognitive decline and complex, multi-factorial pathology. Current single-target drugs provide only limited benefits, and there is a need for more effective therapeutic strategies. β-asarone, a major volatile…
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Journal Article
p40-engineered CAR T-cells targeting CD276 enhance anti-tumor efficacy in non-small cell lung cancer
Background: Chimeric antigen receptor (CAR) T-cells have shown remarkable therapeutic efficacy in hematological malignancies; however, effective breakthroughs in solid tumors have not yet been achieved. Objectives: This study aimed to explore the therapeutic potential of p40-engineered CAR T-cells…
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Journal Article
A Notch signaling antagonist (DAPT) ameliorates autoimmune arthritis in mice by suppressing Th1 and Th17 immune responses
Background: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease for which targeted therapies remain limited. The Notch signaling pathway has been implicated in T cell differentiation and autoimmune inflammation. Objectives: This study aimed to investigate the therapeutic effects…
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Journal Article
Protective effects of Astragalus microcephalus polysaccharides combined with vitamin E and selenium against mercury-induced ovarian toxicity in female rats
Background: Exposure to mercury (Hg) is well-established to induce menstrual cycle disorders and disrupt sex hormone functions. Astragalus species, characterized by their potent antioxidant and anti-apoptotic properties, have shown potential in mitigating these adverse effects by promoting…
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Journal Article
Albiflorin suppresses breast cancer via the HINT2/NLRP3 signaling pathway
Background: Breast cancer (BC) remains a significant global health threat with complex pathogenesis often linked to chemotherapy resistance and inflammatory microenvironments. Histidine triad nucleotide-binding protein 2 (HINT2) is a mitochondrial protein involved in metabolism and immunity, but…
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