3 hasil untuk "Tracy Cheever"

Improved delivery of broadly neutralizing antibodies by nanocapsules suppresses SHIV infection in the CNS of infant rhesus macaques

Jing Wen; Tracy Cheever; Lan Wang dkk.

PLOS Pathogens, Vol. 17 No. 7 · 2021 · Inggris · PLOS Scopus

Broadly neutralizing antibodies (bNAbs) directed to HIV-1 have shown promise at suppressing viremia in animal models. However, the use of bNAbs for the central nervous system (CNS) infection is confounded by poor penetration of the blood brain barrier (BBB). Typically, antibody concentrations in…

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Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity

Mariya B. Shapiro; Tracy Cheever; Delphine C. Malherbe dkk.

Nature Communications, Vol. 11 No. 1 · 2020 · Inggris · DOAJ Scopus

Broadly neutralizing antibodies (bNAbs) are being evaluated for HIV post-exposure prophylaxis (PEP) in the setting of vertical transmission. Here, using a macaque model of perinatal SHIV infection, the authors show that PEP for infant macaques within 30–48 h of SHIV exposure is highly effective…