40,148 results
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Journal Article Full text
NF-κB in biology and targeted therapy: new insights and translational implications
NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was identified as a pivotal pathway in mediating inflammatory responses. However, with extensive and in-depth investigations, researchers have discovered that its role can be expanded to a variety of signaling…
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Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
BACKGROUND: Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor…
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A Phase 3, Randomized, Controlled Trial of Resmetirom in NASH with Liver Fibrosis
BACKGROUND: Nonalcoholic steatohepatitis (NASH) is a progressive liver disease with no approved treatment. Resmetirom is an oral, liver-directed, thyroid hormone receptor beta-selective agonist in development for the treatment of NASH with liver fibrosis. METHODS: We are conducting an ongoing phase…
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Book Full text
World Reference Base for Soil Resources. International soil classification system for naming soils and creating legends for soil maps
The first edition of the World Reference Base for Soil Resources (WRB) was released at the 16th World Congress of Soil Science at Montpellier in 1998. At the same event, it was also endorsed and adopted as the system for soil correlation and international communication of the International Union of…
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The EMBL-EBI Job Dispatcher sequence analysis tools framework in 2024
The EMBL-EBI Job Dispatcher sequence analysis tools framework (https://www.ebi.ac.uk/jdispatcher) enables the scientific community to perform a diverse range of sequence analyses using popular bioinformatics applications. Free access to the tools and required sequence datasets is provided through…
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The Galaxy platform for accessible, reproducible, and collaborative data analyses: 2024 update
Galaxy (https://galaxyproject.org) is deployed globally, predominantly through free-to-use services, supporting user-driven research that broadens in scope each year. Users are attracted to public Galaxy services by platform stability, tool and reference dataset diversity, training, support and…
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Prediction of Daily Climate Using Long Short-Term Memory (LSTM) Model
Climaate prediction plays a vital role in various sectors, including agriculture, disaster management, and urban planning. Traditional methods for climate forecasting often rely on complex physical models, which require substantial computational resources and may not accurately capture local…
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Heavy metals: toxicity and human health effects
Abstract Heavy metals are naturally occurring components of the Earth’s crust and persistent environmental pollutants. Human exposure to heavy metals occurs via various pathways, including inhalation of air/dust particles, ingesting contaminated water or soil, or through the food chain. Their…
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Generalized biomolecular modeling and design with RoseTTAFold All-Atom
Deep-learning methods have revolutionized protein structure prediction and design but are presently limited to protein-only systems. We describe RoseTTAFold All-Atom (RFAA), which combines a residue-based representation of amino acids and DNA bases with an atomic representation of all other groups…
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Sustainable Fashion: Exploring the Concept of Greenwashing and New Trends in the Fashion Industry
The fashion industry, characterized by rapid cycles of production and consumption, has emerged as a global economic powerhouse, generating significant revenue and employment opportunities worldwide. However, this growth has come at a substantial environmental and social cost, marked by extensive…
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Using Machine Learning to Identify Diseases and Perform Sorting in Apple Fruit
Fruit diseases play a major role in global agriculture, leading to substantial crop losses and influencing food production and economic stability. In this age of Industry 4.0 the fruit sorting is an important part in the food processing wherein this work plays a vital role. In this study, a…
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Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants
BACKGROUND: Diabetes can be detected at the primary health-care level, and effective treatments lower the risk of complications. There are insufficient data on the coverage of treatment for diabetes and how it has changed. We estimated trends from 1990 to 2022 in diabetes prevalence and treatment…
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IoT Solutions in Agriculture: Enhancing Efficiency and Productivity
The agricultural sector is on the brink of a transformative era with the emergence of Internet of Things (IoT) technologies. This paper delves into integrating IoT solutions in agriculture, focusing on how these technologies can significantly enhance efficiency, productivity, and sustainability. It…
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The Impact of ESG (Environmental, Social, and Governance) Considerations on Corporate Mergers and Acquisitions: Strategies for Value Creation
The integration of Environmental, Social, and Governance (ESG) considerations in corporate mergers and acquisitions (M&A) has gained significant traction as companies recognize the strategic value of sustainability in dealmaking. This paper explores how ESG factors can be incorporated into M&A…
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Classifying Crop Leaf Diseases using Different Deep Learning Models with Transfer Learning
Within the scope of the research, we put forward a technique of exactly confirming the distinctiveness of agricultural leaf pathologies with the assist of deep mastering algorithms and switch getting to know generation. We have pre-skilled models like VGG19, MobileNet, InceptionV3, EfficientNetB0…
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Analysis of Cylinder Comp Product Quality Control with Proposed Improvements at PT. Jakarta Automotive
In the era of globalization, the manufacturing industry faces its biggest challenge, namely the demands of consumer needs with high quality standards. Various kinds of waste often occur in the production process, one of which is caused by a poor layout of facilities, for example the arrangement of…
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Investigating Non-Newtonian Fluid Behavior in Hydrocyclones Via Computational Fluid Dynamics
Expert researchers examine complex patterns of pressure, viscosity, and velocity in a CFD study of viscoelastic food inside hydrocyclones to obtain a detailed grasp of particle behavior and fluid dynamics. Velocity profiles show how fluids and particles flow through the hydrocyclone in complex…
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Millet based Nutritious Powder for the Geriatric Population
Objective: This study aimed to utilize finger millet as a primary ingredient for creating nutritious millet powder suitable for hot beverages. Desiccated coconut was incorporated for color enhancement. The optimization process involved sensory evaluation and trials on a laboratory scale. Three…
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The Overview on Effectiveness of Quality Enhancement for Enhancing Health Care and Professional Practice
Reorganizing the structure and delivery of services has been a typical focus of initiatives to improve the standard, safety, and effectiveness of health care delivery. Continuous quality improvement (CQI), a technique commonly used in the manufacturing and industrial sectors, has been applied to…
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A Detailed Case Study on Deviation, Out-of-Specification(OOS) and CAPA Generation in Pharmaceutical Industry
This review provide an overview of the various documentation of quality management system, which includes deviations, OOS and CAPA. A detailed case study of deviations, out-of-Specification and CAPA generation is beneficial for improving pharmaceutical capabilities and understanding the…
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