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We need to correct the wide-spread omission of equal contribution in article indexing
As team science grows, so do ‘equal contribution’ designations, yet this information is routinely hidden or lost, creating inequity in recognition and crediting. We must fix this problem, now. Equal contribution designations (co-first and co-last authorship) is on the rise, yet this information is…
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Effects of sensorimotor delays and muscle force capacity limits on the performance of feedforward and feedback control in animals of different sizes
Animals rely on feedforward and feedback control for perturbation responses. When comparing terrestrial mammals of different sizes, we generally find that several features that affect perturbation responses change—larger animals have longer sensorimotor time delays, heavier body segments, and…
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Inducible gene deletion reveals essentiality of protein kinases and a septation initiation network in Candida albicans
Protein kinases are key components of many signaling pathways that regulate cellular activities, and some of them are indispensable for the viability of cells. We used inducible gene deletion to assess the importance of a set of putative essential protein kinases for growth and viability of the…
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The circadian clock gene CYCLE as a potential target for disrupting blood-feeding behavior in the mosquito Culex pipiens
Background: C. pipiens blood feeding rhythm exhibits a circadian rhythm that have the ability to persist under absent of environmental cues, consistent with endogenous control. Variations observed in the blood feeding rhythm is accompanied by changes in CYCLE (CYC) expression and olfactory…
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Quantifying the role of pre-existing tissue resident cellular immunity in limiting respiratory virus transmission
Viral transmission from infected donors to uninfected recipients is the key event underlying the spread of viral pathogens at the level of a host population. Successful viral transmission from a donor to a recipient depends on several factors including the infectiousness of the donor. Donor…
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Diagnostic performance of peripheral nerve palpation compared with ultrasonography in leprosy neuropathy: A prospective real-world clinical evaluation
Background: Leprosy frequently causes peripheral neuropathy, and nerve palpation remains a cornerstone of diagnosis in many endemic settings despite its subjectivity and limited reproducibility. High-resolution ultrasonography has emerged as a sensitive, low-cost imaging tool to detect peripheral…
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Broadly conserved protective epitopes on the lyme disease vaccine antigen, OspA
Lyme disease, caused by the spirochete, Borrelia burgdorferi sensu latu (Bbsl), is a tickborne infection of increasing incidence in North America, Europe and Asia. While vaccines based on Outer surface protein A (OspA) have proven highly efficacious at blocking Bbsl tick-to-human transmission, the…
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Epigenetic gene regulation is controlled by distinct regulatory complexes utilizing specialized paralogs of TELOMERE REPEAT BINDING FACTORS
Epigenetic regulators shape chromatin landscapes, allowing cells to express distinct gene sets depending on cell-type, developmental stage or environmental cues. These regulatory complexes rely on interactions with sequence-specific DNA binding proteins, such as the small family of TELOMERE REPEAT…
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Understanding Calabar swellings: Assessing subcutaneous loiasis using ultrasound
Loiasis is known for two main clinical manifestations: eyeworm and Calabar swellings. Calabar swellings are non-pitting edemas, often on the upper limbs or presenting as unilateral orbital swelling. They are described as itchy or painful, limit mobility, and cause notable morbidity. Although adult…
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Genomic and functional adaptations in the guanylate-binding protein GBP5 highlight specificities of bat antiviral innate immunity
Bats are asymptomatic reservoirs of several zoonotic viruses. This may result from long-term co-evolution between viruses and bats, that have led to host adaptations contributing to an effective balance between strong antiviral responses with innate immune tolerance. To better understand these…
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Efficacy of oxfendazole treatment against infective larvae of Litomosoides sigmodontis
Filarial infections are prevalent worldwide and affect both humans and animals. Two filarial infections, lymphatic filariasis and onchocerciasis, are listed among the neglected tropical diseases by the WHO and targeted for their elimination via large-scale public health campaigns in the affected…
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A kappa opioid receptor agonist, difelikefalin, improves acute kidney injury in experimental sepsis models
There is a pressing need for therapies that can lessen the severity of acute kidney injury (AKI) and subsequent critical illness. Difelikefalin, a peripherally acting kappa opioid receptor agonist, shows promise in controlling postoperative pain and chronic kidney disease-associated pruritis. Here…
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Clinical outcomes and associated factors among mechanically ventilated patients in adult intensive care unit at Jimma Medical Center, Southwest Ethiopia, 2024
Background: Mechanical ventilation (MV) is a life‑saving intervention for patients unable to maintain adequate oxygenation or ventilation. However, MV is also associated with complications such as ventilator‑associated pneumonia, lung injury, and prolonged ICU stay, which may increase morbidity and…
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EDCC-RPL: A novel energy-efficient and load-balanced objective function for RPL Routing in IoT networks enhancing network lifetime and reliability
Energy efficiency and balanced load distribution remain persistent challenges in the Routing Protocol for Low-Power and Lossy Networks (RPL), significantly affecting the lifetime and reliability of Internet of Things (IoT) deployments. This study introduces EDCC-RPL, a novel multi-metric objective…
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CORE-Net: A cross-modal orthogonal representation enhancement network for low-altitude multispectral object detection
Object detection in visible light (RGB) images is frequently compromised by low-illumination conditions, whereas infrared (IR) imaging typically exhibits superior robustness in such environments. Multispectral fusion addresses this limitation by leveraging complementary information from both…
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The normal human lymph node cell classification and landscape defined by high-dimensional spatial proteomics
Lymph nodes (LN) are key secondary lymphoid organs (SLO) for a coordinated immune response. They have been extensively characterized by numerous investigative techniques chiefly as single cell suspensions because they are composed of vagile yet crowded hematolymphoid elements, unfriendly to spatial…
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Trimineralic abalone shells ( Haliotis iris Gmelin, 1791) and X-ray diffractometry: A Bayesian calibration model for resolving complex skeletal mineralogy
X-ray diffractometry (XRD) is commonly used to determine both aragonite:calcite ratio and Mg content (in calcite) in biogenic skeletal carbonate. Bimineral taxa, such as many abalone, combine aragonite and calcite, or sometimes two distinct calcites, in a single skeleton. At least some abalone…
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A hybrid CNN-XLSTM-GRU deep learning model with autoencoder-based feature selection for hypothyroidism diagnosis
Hypothyroidism, caused by reduced thyroid-hormone production, is often difficult to diagnose because its symptoms are non-specific and overlap with other disorders. We developed FusionNet-CXG, a hybrid deep-learning model that couples CNN, eXtended LSTM, and GRU components for hypothyroidism…
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The effect of air pollution on catastrophic health expenditure among middle-aged and older adults in China
Background: Catastrophic health expenditure (CHE) reflects the financial protection level towards the universal health coverage target. Air pollution is a major contributor to the economic burden of diseases. However, the relationship between air pollution and CHE remains largely unexplored. This…
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