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Fast and interpretable quantification of biological shape heterogeneity via stratified Wasserstein kernel
Modern imaging technologies produce vast collections of cellular and subcellular structures, calling for principled methods that enable shape comparison across individuals and populations. We introduce the stratified Wasserstein framework, which treats each shape as an unstructured point cloud and…
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Tumour-driven lipid accumulation in oenocytes reflects systemic lipid alterations
Cancer cachexia is a multifactorial syndrome characterized by systemic metabolic dysfunction, including liver steatosis. In this study, we examined the role of larval oenocytes - hepatocyte-like cells, in a Drosophila model of cancer cachexia. We found that oenocytes in tumour-bearing larvae…
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The KMT2F histone methyltransferase interacts with the RNA polymerase I machinery to promote ribosomal RNA transcription
Trimethylation of histone 3 lysine 4 (H3K4me3) is a mark of active transcription, and its regulatory role in RNA polymerase II-mediated transcription has been well-studied. However, if and how this mark regulates RNA polymerase I (RNA Pol I) is not known. Here, we used customized genome assemblies…
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PLoS Computational Biology Issue Image | Vol. 22(4) May 2026
Cup formation on a phagocyte membrane during particle engulfment: This image illustrates cup formation on a phagocyte membrane during particle engulfment. Our modelling shows that membrane tension, a key but often overlooked physical factor, strongly influences phagocytic progression and can…
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PLoS Pathogens Issue Image | Vol. 22(4) May 2026
Conidiophores of wheat powdery mildew on a wheat leaf: The stereo microscope photo shows mature conidiophores on a hexaploid wheat leaf. This study compared the genomes of various isolates from the species of powdery mildew (Blumeria graminis) depicted in this photo, using pangenomics and…
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PLoS Genetics Issue Image | Vol. 22(4) May 2026
Possible model of sex determination in the wild yam Dioscorea tokoro: Dioscorea tokoro has XY male and XX female sex determination system. Two genes, BLH9 and HSP90, located on the Y-region are hypothesized to be responsible for the generation of male flowers (Top). Lack of the two genes generates…
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Real environment obstacle circular edge expansion design robot path planning based on ant colony algorithm
With the development of artificial intelligence, mobile robot motion control technology is facing the key problem of intelligent path planning. The combination of a grid map and an artificial intelligence algorithm provides an effective solution for path planning. However, the current grid map…
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Integration of HIV, Hepatitis B, and C, and sexually transmitted infections services: A scoping review of the benefits and challenges
Background: Integrating clinical programs and services is a cost-effective approach that can improve health and system outcomes. This review aimed to provide an overview of the benefits and challenges of integrated programs for HIV, hepatitis B and C, and STI services worldwide and provide…
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Adaptive strategies of Egyptian crowfoot grass ( Dactyloctenium aegyptium (L.) Willd): Germination responses to environmental factors
Egyptian crowfoot grass (Dactyloctenium aegyptium (L.) Willd.) is a troublesome C4 grass weed that competes with crops such as rice (Direct Seeded Rice), sugarcane and urban green space. The effects of constant and alternating temperatures, storage times, light, salinity, and water stress on…
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Wolbachia -induced Cytoplasmic Incompatibility drives epigenetic and maternally-influenced post-embryonic defects
A common form of Wolbachia-induced manipulation of host reproduction is Cytoplasmic Incompatibility (CI). In CI, Wolbachia modification of sperm results in pronounced defects in paternal chromosome condensation, replication, and segregation during the first mitotic division. Recent studies in D…
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Mass drug administration for soil-transmitted helminthiasis and schistosomiasis in selected districts of Rwanda: Coverage, implementation factors, and household water, sanitation, and hygiene conditions
Background: In Rwanda, about 1 in 3 people are affected by soil-transmitted helminthiases (38.7%) and 1 in 4 by schistosomiasis in high-risk areas (27.2% by point-of-care circulating cathodic antigen), both associated with poor water, sanitation, and hygiene (WASH). Mass drug administration (MDA)…
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Evaluation and estimation of epidemic trajectories for SARS-CoV-2 from clinical and wastewater data in Gauteng Province, South Africa
Inferring epidemic trajectories of viral infections from wastewater data can be a useful addition to clinical-based surveillance, as it provides low cost, population-level data that includes both symptomatic and asymptomatic individuals who contribute to the sewer system. However, methods for…
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Computational modeling of intravitreal ranibizumab kinetics: Predicting macular drug concentration and half-life
Ranibizumab is a key anti-VEGF therapeutic used to improve treatment efficacy and reduce injection frequency in neovascular retinal diseases. Because experimental pharmacokinetic data in humans are limited, computational modeling provides an effective means to predict ocular drug behavior. In this…
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Gut microbiota of Brazilian Melipona stingless bees: Dominant members and their localization in different gut regions
The gut microbiome of eusocial corbiculate bees, which include honeybees, bumblebees, and stingless bees, consists of anciently associated, host-specific bacteria that play crucial role in nutrition, pathogen defense and host fitness. While the core microbiota of honeybees and bumblebees is well…
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A new target: AlkBH2 promotes bladder cancer by upregulation of inflammation
A close relationship exists between inflammation and cancer. Recent studies have highlighted inflammation as a significant contributor to the progression of bladder cancer. However, the role of alkyladenine DNA glycosylase homolog 2 (AlkBH2), an enzyme involved in DNA repair and a member of the…
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Use of implementation science models, theories, and frameworks in pediatric rehabilitation: Protocol for a scoping review
Introduction: Implementation science frameworks – including process models, determinant frameworks, classic theories, implementation theories, and evaluation frameworks – are increasingly used to guide the translation of evidence-based interventions into practice. In paediatric rehabilitation…
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Effects of deconstructed Tai Chi step training combined with conventional rehabilitation on lower limb function in brunnstrom stage III stroke patients: A randomized controlled trial
Objective: To evaluate whether a deconstructed Tai Chi stepping protocol adapted for patients with Brunnstrom Stage III stroke, when combined with conventional rehabilitation, improves lower limb motor function, walking ability, and joint mobility compared with conventional rehabilitation plus limb…
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Feasibility assessment of double-blind, crossover, randomized controlled trial protocol comparing two oxygen-supplemented pulmonary rehabilitation for patients with chronic obstructive pulmonary disease: A pilot study
Background: Pulmonary rehabilitation (PR) for patients with chronic obstructive pulmonary disease (COPD) improves exercise tolerance and COPD assessment test score (CAT). Oxygen supplementation during PR facilitates exercise physiological benefits. This study aimed to assess the feasibility of a…
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Towards reliable use of artificial intelligence to classify otitis media using otoscopic images: Addressing bias and improving data quality
Ear disease contributes significantly to global hearing loss, with recurrent otitis media being a primary preventable cause in children, impacting development. Artificial intelligence (AI) offers promise for early diagnosis via otoscopic image analysis, but dataset biases and inconsistencies limit…
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Microbial fuel cells for wastewater treatment and electricity production: A multi-platform simulation workflow
The need for sustainable energy generation and efficient wastewater treatment continues to motivate technologies that integrate energy recovery with environmental remediation. Here, a microbial fuel cell (MFC) system is designed and evaluated, leveraging electrogenic microorganisms to produce…
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