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Digitizing microscope slide-based natural history collections: A protocol using slide scanner technology
Natural history collections contain millions of microscope slides documenting global microscopic biodiversity, yet these materials remain largely undigitized and are vulnerable to deterioration and loss. Recent advances in slide scanner technology, originally developed for medical pathology, offer…
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Nebivolol suppresses glioblastoma progression via dual modulation of mitochondrial metabolism and AKT/mTOR/4EBP1 signaling axis
Emerging evidence reveals the pivotal involvement of mitochondrial metabolic dysregulation in glioblastoma (GBM) pathogenesis, considering mitochondrial metabolism as a potential therapeutic target. Nebivolol, a third-generation β-adrenergic receptor antagonist clinically employed in cardiovascular…
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The Lions Sports Academy Tackle TEK Tool: The intra-and inter-coach reliability of assessing tackling competency in rugby union
Tackling skill tests in rugby aim to evaluate skill competency, but their reliability to detect meaningful changes in tackling competency over time remains uncertain. This study aimed to: 1) determine the intra- and inter-rater reliability of scoring composite tackle competency by three youth…
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Bowhead whale foraging dives are defined by speed and body orientation
Quantifying the time baleen whales spend foraging is central to understanding the extent to which climate driven shifts in low-trophic prey may affect energy acquisition. To date, the most comprehensive understanding of balaenid (bowhead and right whale) feeding behavior comes from studies using…
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Relationship between dietary thiamine, riboflavin, and niacin intake and hypertension subtypes: A cross-sectional study from the 1999–2023
Background: This cross-sectional study aimed to investigate whether vitamin B intake (thiamine, riboflavin, niacin) influences different hypertension subtypes and which subtype exhibits a more profound effect. The objective was to determine whether different vitamins should be supplemented…
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The application of large language models in meteorology graduate research: current status, impact, and prospects
With the rapid development of generative artificial intelligence, large language models (LLMs) have gradually integrated into various fields, demonstrating significant potential, particularly in meteorological research. This study explores the current application, advantages, challenges, and future…
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Machine learning identifies pupil size and corneal thickness as key predictors of axial elongation rate
Purpose: This study aimed to develop a machine learning-based prediction model for myopia progression using ocular biometric parameters to provide an objective assessment tool for clinical practice. Methods: A retrospective analysis was conducted on patients treated at Shanghai Parkway Health…
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Obesity and cancer: Methodological frontiers for mechanistic discoveries
It has long been a biological mystery why obesity increases cancer risk. Rapid advances in statistical and analytical methods are now opening the door to mechanistic discoveries that may finally resolve this question. Why obesity increases cancer risk has long remained a biological mystery. In this…
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Emergent spatial structure in the gut microbiota is driven by bacterial growth and gut contractions
Spatial structure can functionally determine ecological interactions and evolution of microbial communities. The gut microbiota is known to be spatially structured longitudinally along the gastrointestinal tract, but micro-scale structure in the gut lumen has not been extensively explored. Here, we…
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Structural mechanisms underlying distinct binding and activities of 18:0 and 18:1 lysophosphatidic acids at LPA1 receptor
Lysophosphatidic acids (LPAs) are bioactive lipids that regulate numerous physiological functions in humans. Cell signaling by LPAs is mediated mainly via six LPA receptors (LPA1-6), class A G protein-coupled receptors (GPCRs). Among these, LPA1 is recognized to play an essential role in cell…
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A cortico-subthalamic circuit rapidly engages and releases inhibition of specific movements depending on the environmental context
Response inhibition is an important cognitive control mechanism that enables flexible behavior by stopping inappropriate actions. Intracranial recordings across species have identified a neural circuit that implements response inhibition via the subthalamic nucleus of the basal ganglia. However…
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Carbon budget of common urban tree species in an arid city based on life cycle assessment
Urban trees sequester and store carbon through photosynthesis, while their planting and maintenance processes consume energy and materials, resulting in the release of carbon back into the atmosphere. Therefore, a comprehensive and scientifically rigorous assessment of the net carbon sequestration…
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Patients’ perception and needs of spiritual care: A qualitative study in the context of prolonged hospitalizations
Spiritual care is recognized as a core component of holistic nursing, particularly for patients experiencing prolonged hospitalization. Extended hospital stays may intensify spiritual needs by disrupting daily routines, limiting engagement in religious practices, and increasing existential…
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Anemia among HIV‑positive women in LMICs: Multilevel analysis of recent DHS survey
Introduction: Anemia affects over 30% of women of reproductive age globally, with the highest burden in low‑ and middle‑income countries, and it poses additional risks for women living with human immunodeficiency virus (HIV), including disease progression and reduced survival. Although previous…
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Community engagement for vaccine delivery in low- and middle-income countries and humanitarian settings: A scoping umbrella review
Vaccination is a critical public health intervention in humanitarian and low- and middle-income country (LMIC) settings, where populations face heightened risks of vaccine-preventable diseases. Community Engagement (CE) offers a pathway to address challenges related to local ownership, trust, and…
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CMAP-Fusion: A cross-modal feature selection and model pruning framework for laboratory and imaging data
Cross-modal fusion of medical imaging and laboratory data is a key pathway for accurate diagnosis of diseases, yet it is constrained by issues such as the modal heterogeneity gap, accumulation of feature redundancy, and efficiency imbalance. Existing methods struggle to balance precision and…
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Gender disparities in Italian academic medicine: A cross-sectional study of clinicians in the 2024 stanford top 2% scientists database
Background: Women remain underrepresented in senior and influential research positions despite gradual improvements over recent decades.The aim of this study was to assess gender representation among highly cited Italian clinical scientists and to examine differences across academic fields…
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Associated factors of health-related quality of life in Indonesian Women with Systemic Lupus Erythematosus: A cross-sectional within-cohort analysis
Objective: This study aims to determine the effects of sleep quality along with age, marital status, socioeconomic status, depression, anxiety, disease activity, pain scale, and dose of corticosteroids on quality of life in women with SLE. Methods: Variables were assessed in 75 women with SLE using…
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Vulnerabilities, extreme weather and temporal tensions as experienced by construction workers in the Swedish construction sector
Aim: Climate change poses increasing risks to outdoor occupations, including construction work. This study explores how vulnerability is constructed in narratives of manual labour within the Swedish construction sector, particularly under extreme weather conditions. Methods: Drawing on 16…
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The impact of COVID-19 vaccination on long-term risk of new-onset atrial fibrillation/flutter after COVID-19 infection: A retrospective cohort study
Purpose: COVID-19 infection has been associated with cardiovascular complications, including new-onset atrial fibrillation/flutter (NOAF). However, the potential protective effect of COVID-19 vaccination against long-term NOAF risk following COVID-19 infection remains unclear. Methods: This…
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