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Self-efficacy and self-regulated learning strategies as significant predictors of english writing proficiency in Chinese EFL senior high school students
Self-efficacy and self-regulated learning strategies are crucial importance for enhancing the writing proficiency of foreign language learners. This study employed a cross-sectional design to examine the relationships among writing self-efficacy, writing self-regulated learning strategies and…
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Operationalization of Severe Maternal Morbidity surveillance in administrative databases of the Brazilian public and private health systems: Brazil 2015–2022
The study of severe maternal morbidity (SMM) is an important strategy for improving the quality of obstetric care. The objective of this study is to assess SMM cases recorded in the Hospital Information System of the Unified Health System (SIH/SUS), which contains public funded hospitalizations…
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DJ-1 alleviates high glucose-induced podocyte injury via activating ERK1/2 signaling
Diabetic nephropathy (DN) is a major diabetic complication, and while DJ-1 has been shown to mitigate renal ischemia/reperfusion injury, its role in high glucose-induced podocyte damage remains unclear. This study aimed to investigate the function and mechanism of DJ-1 in high glucose-induced…
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Study on the mechanical behavior and fracturing mechanism of rock containing two unparallel prefabricated fissures under uniaxial loading
As a natural material, rock is widely used in construction and building engineering, such as wall brick and road foundations. However, natural rock usually contains fissures and fractures, which greatly affect the long-term structural stability. In this paper, the mechanical behavior and fracturing…
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Functional hearing and low frequency hearing preservation after cochlear implant surgery is achievable with FLEX electrode arrays: Real world evidence from the MEHS Registry
This study uses data from the MED-EL Hearing Solutions (MEHS) multicenter registry to examine the impact of a series of flexible lateral wall electrode arrays on postoperative low frequency hearing preservation (LFHP) of cochlear implant (CI) users. Participants were members of the MEHS registry…
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Japanese encephalitis virus orchestrates GLUT4-mediated glucose metabolism to potentiate viral replication via insulin receptor signaling
Flaviviruses intricately rewire host metabolic networks to establish a replication-permissive environment; however, the role of glucose transporter-mediated uptake, particularly via glucose transporter 4 (GLUT4), remains insufficiently defined. Japanese encephalitis virus (JEV) infection induces…
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Constitutively active RAS prolongs Cdc42 signalling, while MAPK signalling is attenuated during fission yeast mating
The small GTPase RAS is a signalling hub activating multiple pathways, which may respond differently to a constitutively active RAS mutation. We explored this issue in fission yeast, where RAS-mediated pheromone signalling (PS) activates two downstream pathways: the MAPKSpk1 and Cdc42 pathways. We…
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Development and validation of an early risk-stratification model for hemophagocytic lymphohistiocytosis in severe fever with thrombocytopenia syndrome
Objective: To develop and validate a model for early risk stratification of secondary hemophagocytic lymphohistiocytosis (HLH) in patients with severe fever with thrombocytopenia syndrome (SFTS). Methods: This retrospective cohort included adults with laboratory-confirmed SFTS admitted to The First…
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Neural population dynamics and temporal context cells in macaque medial parietal cortex support temporal order memory
Episodic memory involves encoding and remembering the order of events experienced over time. Previous work examining the mechanisms of temporal order memories has focused primarily on the hippocampus and prefrontal cortices, with comparatively less attention paid to population-level memory signals…
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Double-CRISPR Knockout Simulation (DKOsim): A Monte-Carlo randomization system to model cell growth behavior and infer the optimal library design for growth-based double knockout screens
Advances in functional genomic technology, notably CRISPR using Cas9 or Cas12, now allow for large-scale double perturbation screens in which pairs of genes are inactivated, allowing for the experimental detection of genetic interactions (GIs). However, as it is not possible to validate GIs in…
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New transcription signals in SARS-CoV-2 reshape virus–host interactions
Non-spike changes driving SARS-CoV-2 fitness remain undercharacterized. Two PLOS Biology papers show that evolutionary N gene changes create a transcription-regulating sequence producing a truncated N protein that enhances fitness by blocking antiviral responses. Non-spike changes driving…
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A phase-field model for vesicle membranes incorporating area-difference elasticity
This paper presents a phase-field model for simulating the three-dimensional deformation of vesicle membranes, incorporating area-difference elasticity (i.e., the elasticity arising from the difference between the inner and outer lipid leaflets), with constraints on bulk volume and surface area. We…
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SCGAN-generated skin-tone-balanced extension of the HAM10000 dataset for fairer dermatological AI
This dataset presents a synthetic collection of skin lesion images generated using a tone-conditioned Generative Adversarial Network (GAN) to model skin tone variation in dermatological datasets, motivated by the limited representation of darker skin tones in commonly used benchmarks. The dataset…
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The complete mitochondrial genome of Holothuria atra (Holothuriida: Holothuriidae: Holothuria ) and its structural characteristics
Sea cucumbers, as typical representatives of deep-sea benthic animals, possess significant scientific and economic importance. This investigation examined the genomic structural characteristics and genetic evolutionary relationships of Holothuria atra through the analysis of its complete…
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Implementation fidelity of a community-based Aedes aegypti breeding site elimination program for dengue control in southeastern Mexico
Introduction: Dengue is a globally significant arboviral disease in tropical regions such as southeastern Mexico. The “Healthy Environments and Communities” (E&CS) program, led by the Health Secretariat, promotes community practices to eliminate Aedes aegypti breeding sites. However, factors…
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Uptake and determinants of immediate and extended postpartum long-acting reversible contraceptive use in Eastern and Western Africa: A systematic review and meta-analysis
Background: Reducing unintended pregnancies and improving maternal/child health relies heavily on postpartum family planning (PPFP). Despite their high effectiveness, the use of long-acting reversible contraceptives (LARC), such as intrauterine contraceptive device (IUCD) and implants, is…
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Quantifying lead (Pb) leaching from galvanized handpump spouts, leaded brass taps, and stainless-steel alternatives using the NSF 61 test protocol: Implications for safe rural water supply
Lead (Pb) is a neurotoxin with no known safe level of exposure. Widespread lead contamination has been reported in rural groundwater-supplied drinking water systems in low- and middle-income countries (LMICs), primarily arising from the corrosion of lead-containing plumbing materials such as…
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A novel SLC20A2 nonsense variant and mechanistic studies of primary brain calcification
Primary brain calcification (PBC) is a rare neurodegenerative disease featured by bilateral brain calcifications and exhibiting high phenotypic and genetic heterogeneity. The clinical manifestations mainly include movement disorders, cognitive deficits, and neuropsychiatric symptoms. In this study…
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Comparison of OneChoice AI-based clinical decision support recommendations with infectious disease specialists and non-specialists for bacteremia treatment in Lima, Peru
Bacteremia is a major contributor to global morbidity and mortality, particularly in low- and middle-income countries where diagnostic delays and empirical antimicrobial misuse exacerbate resistance. This study assessed the accuracy of OneChoice®, an artificial intelligence (AI)-based Clinical…
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Examining the infographic design instructional process in terms of prospective mathematics teachers’ infographic design proficiency, self‑efficacy, and abilities in evaluating student errors: A model proposal
The rapid integration of digital visualization tools into teacher education programs has created new opportunities for enhancing instructional design skills in mathematics education. This study investigates the impact of a technology-enhanced infographic design instructional process on prospective…
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