321 hasil
Menampilkan 1–20 · 0,78 detik · RSS
JAMA
ISSN 0002-9955 · American Medical Association · 321 artikel di indeks
-
Artikel Jurnal
CONSORT 2025 Statement
Importance: Well-designed and properly executed randomized trials are considered the most reliable evidence on the benefits of health care interventions. However, there is overwhelming evidence that the quality of reporting is not optimal. The CONSORT (Consolidated Standards of Reporting Trials)…
-
Artikel Jurnal
Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function
Importance: Identifying new interventions to slow and prevent cognitive decline associated with dementia is critical. Nonpharmacological interventions targeting modifiable risk factors are promising, relatively low-cost, accessible, and safe approaches. Objective: To compare the effects of two…
-
Artikel Jurnal
Transparent Reporting of Observational Studies Emulating a Target Trial—The TARGET Statement
Importance: When randomized trials are unavailable or not feasible, observational studies can be used to answer causal questions about the comparative effects of interventions by attempting to emulate a hypothetical pragmatic randomized trial (target trial). Published guidance to aid reporting of…
-
Artikel Jurnal Teks lengkap
Endometriosis
Importance: Endometriosis is a chronic, estrogen-dependent, inflammatory disease defined by endometrial-like tissue (lesions) outside the uterine lining. It affects up to 10% of women worldwide, and 9 million women in the US, during reproductive years. Observations: Endometriosis has varying…
-
Artikel Jurnal Teks lengkap
Analysis of Breast Cancer Mortality in the US—1975 to 2019
Importance: Breast cancer mortality in the US declined between 1975 and 2019. The association of changes in metastatic breast cancer treatment with improved breast cancer mortality is unclear. Objective: To simulate the relative associations of breast cancer screening, treatment of stage I to III…
-
Artikel Jurnal
Perioperative Toripalimab Plus Chemotherapy for Patients With Resectable Non–Small Cell Lung Cancer
Importance: Adjuvant and neoadjuvant immunotherapy have improved clinical outcomes for patients with early-stage non-small cell lung cancer (NSCLC). However, the optimal combination of checkpoint inhibition with chemotherapy remains unknown. Objective: To determine whether toripalimab in…
-
Artikel Jurnal Teks lengkap
CAR T Cells and T-Cell Therapies for Cancer
Importance: Chimeric antigen receptor (CAR) T cells are T lymphocytes that are genetically engineered to express a synthetic receptor that recognizes a tumor cell surface antigen and causes the T cell to kill the tumor cell. CAR T treatments improve overall survival for patients with large B-cell…
-
Artikel Jurnal Teks lengkap
Renal Cell Carcinoma
Importance: Renal cell carcinoma (RCC) is a common malignancy, with an estimated 434 840 incident cases worldwide in 2022. In the US, it is the sixth most common cancer among males and ninth among females. Observations: Clear cell RCC is the most common histologic subtype (75%-80% of cases) and is…
-
Artikel Jurnal Teks lengkap
Long-Term Outcomes of Medical Management vs Bariatric Surgery in Type 2 Diabetes
Importance: Randomized clinical trials of bariatric surgery have been limited in size, type of surgical procedure, and follow-up duration. Objective: To determine long-term glycemic control and safety of bariatric surgery compared with medical/lifestyle management of type 2 diabetes. Design…
-
Artikel Jurnal Teks lengkap
Blood Biomarkers to Detect Alzheimer Disease in Primary Care and Secondary Care
Importance: An accurate blood test for Alzheimer disease (AD) could streamline the diagnostic workup and treatment of AD. Objective: To prospectively evaluate a clinically available AD blood test in primary care and secondary care using predefined biomarker cutoff values. Design, Setting, and…
-
Artikel Jurnal
Testing and Evaluation of Health Care Applications of Large Language Models
Importance: Large language models (LLMs) can assist in various health care activities, but current evaluation approaches may not adequately identify the most useful application areas. Objective: To summarize existing evaluations of LLMs in health care in terms of 5 components: (1) evaluation data…
-
Artikel Jurnal
Age-Related Macular Degeneration
Importance: Age-related macular degeneration (AMD) affects approximately 20 million people in the US and 196 million people worldwide. AMD is a leading cause of severe vision impairment in older people and is expected to affect approximately 288 million people worldwide by 2040. Observations: Older…
-
Artikel Jurnal Teks lengkap
Prevalence of Cardiovascular-Kidney-Metabolic Syndrome Stages in US Adults, 2011-2020
This cross-sectional study assesses the prevalence and temporal evolution of cardiovascular-kidney-metabolic syndrome stages.
-
Artikel Jurnal Teks lengkap
International Consensus Criteria for Pediatric Sepsis and Septic Shock
Importance: Sepsis is a leading cause of death among children worldwide. Current pediatric-specific criteria for sepsis were published in 2005 based on expert opinion. In 2016, the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) defined sepsis as life-threatening…
-
Artikel Jurnal Teks lengkap
Risk Assessment and Prevention of Falls in Older Community-Dwelling Adults
Importance: Falls are reported by more than 14 million US adults aged 65 years or older annually and can result in substantial morbidity, mortality, and health care expenditures. Observations: Falls result from age-related physiologic changes compounded by multiple intrinsic and extrinsic risk…
-
Artikel Jurnal Teks lengkap
Development and Validation of the Phoenix Criteria for Pediatric Sepsis and Septic Shock
Importance: The Society of Critical Care Medicine Pediatric Sepsis Definition Task Force sought to develop and validate new clinical criteria for pediatric sepsis and septic shock using measures of organ dysfunction through a data-driven approach. Objective: To derive and validate novel criteria…
-
Artikel Jurnal
Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer
Importance: The association of tumor-infiltrating lymphocyte (TIL) abundance in breast cancer tissue with cancer recurrence and death in patients with early-stage triple-negative breast cancer (TNBC) who are not treated with adjuvant or neoadjuvant chemotherapy is unclear. Objective: To study the…
-
Artikel Jurnal Teks lengkap
Cardiac Amyloidosis Due to Transthyretin Protein
Importance: Systemic amyloidosis from transthyretin (ATTR) protein is the most common type of amyloidosis that causes cardiomyopathy. Observations: Transthyretin (TTR) protein transports thyroxine (thyroid hormone) and retinol (vitamin A) and is synthesized predominantly by the liver. When the TTR…
-
Artikel Jurnal Teks lengkap
Vibration-Controlled Transient Elastography Scores to Predict Liver-Related Events in Steatotic Liver Disease
Importance: Metabolic dysfunction-associated steatotic liver disease (MASLD) is currently the most common chronic liver disease worldwide. It is important to develop noninvasive tests to assess the disease severity and prognosis. Objective: To study the prognostic implications of baseline levels…
-
Artikel Jurnal Teks lengkap
Appropriateness of Cardiovascular Disease Prevention Recommendations Obtained From a Popular Online Chat-Based Artificial Intelligence Model
This study examines the appropriateness of artificial intelligence model responses to fundamental cardiovascular disease prevention questions.