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Arhiv za farmaciju
Dikeluarkan Scopus 2023
ISSN 0004-1963 · Pharmaceutical Association of Serbia, Belgrade, Serbia · 365 artikel di indeks
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Men's skin care and aesthetic procedures during ageing and andropause
Skin ageing is a multifactorial process influenced by intrinsic and extrinsic factors. Both pathways converge at the molecular level through oxidative stress, inflammation, matrix metalloproteinase activation, DNA damage and impaired collagen homeostasis. In men, intrinsic ageing is affected by…
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Chokeberry pomace: Waste, or a valuable source of bioactive compounds?
Berry pomaces, byproducts of the food industry, are rich in bioactive polyphenolic compounds, which are well recognized for their strong antioxidant and antimicrobial properties. Unfortunately, chokeberry pomace (CBP) often ends up as environmentally harmful waste. In this work, it is shown that…
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Development and optimization of an in vitro release method for β-arbutin from chitosan-hyaluronic acid films
The aim of this study was to develop and optimize an in vitro method for evaluating β-arbutin release from chitosan-hyaluronic acid films for cosmetic use and to investigate the effects of hydrodynamic conditions and formulation composition on release behavior. Films containing β-arbutin were…
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Solid dosage forms with fixed-dose combinations of active pharmaceutical ingredients: Therapeutic importance and review of formulation strategies
Fixed-dose combination (FDC) products contain at least two active pharmaceutical ingredients (APIs) in a single dosage form. Monolithic, multilayer, and multiparticulate formulations are widely employed in the manufacture of solid fixed-dose combination products, such as tablets and capsules. Among…
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Cytotoxicity and ROS scavenging potential of Teucrium montanum L. methanolic extracts in HaCaT cells
Teucrium montanum L. (TM) is a perennial species of the Lamiaceae family, traditionally used in folk medicine for its diverse therapeutic properties. Although previous studies have explored the biological activity of TM extracts, their effects on skin cells have not been investigated. This study…
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Microglial dysfunction and cognitive impairment in animal models of diabetes type 2: A systematic review bridging diabetes and early-stage neurodegeneration
Diabetes Type 2 (T2D) is closely associated with cognitive impairment and an increased risk of dementia. Early neuropathological alterations in T2D are increasingly considered to involve neuroinflammatory processes, suggesting that microglial function in the diabetic brain may be compromised or…
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Development and validation of an RP-HPLC method for the determination of tiazotic acid and its impurity with application to tablet analysis
A simple and precise RP-HPLC method was developed and validated for the determination of tiazotic acid and its impurity, 3-methyl-1,2,4-triazole-5-thione, with application to tablet analysis. Chromatographic analysis was performed using a Hypersil GOLD aQ C18 column (150 × 4 mm, 3 µm) under…
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Sex-specific associations between serum quinolinic acid and disease severity in relapsing-remitting multiple sclerosis: A cross-sectional study
The kynurenine pathway (KP) of tryptophan metabolism generates metabolites with both neuroprotective and neurotoxic properties and has been implicated in multiple sclerosis (MS). However, the relationship between KP metabolites, disease severity, and sex remains unclear. Serum levels of quinolinic…
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In silico evaluation of the antibacterial and antiviral potential of nusbiarylin derivatives
Antimicrobial resistance and chronic viral infections are major challenges in contemporary medicine. This in silico study evaluated the dual inhibitory potential of 16 designed nusbiarylin derivatives against two clinically relevant enzymatic targets: Escherichia coli (E. coli) RNA polymerase…
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Pharmacists' knowledge and attitudes regarding biologics and biosimilars: A literature review
Advancements in biologic therapies have become crucial for managing both acute and chronic illnesses. In addition, the growing presence of biosimilar medications presents significant opportunities for reducing healthcare costs and expanding patient access to essential biologic treatments…
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Microencapsulation techniques for cannabinoids: Pharmaceutical approaches, technological challenges, and formulation perspectives
Microencapsulation is a widely applied strategy for protecting bioactive compounds by entrapping them within a polymeric or lipid-based shell, thereby enhancing their stability and enabling controlled release. In recent years, the growing number of applications of cannabinoids has driven increasing…
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The placebo effect in mental health: Psychological, neurobiological, and ethical aspects
The placebo effect is a psychobiological phenomenon in which patients' expectations, prior experiences, and social context influence health outcomes, even in the absence of active pharmacological treatment. Key mechanisms include expectancy, verbal suggestion, classical conditioning, and…
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Optimization of sample preparation and analytical performance evaluation for a model polar compound in hydroxypropyl methycelulose-based controlled-release tablets
Controlled-release (CR) tablets based on hydroxypropyl methylcellulose (HPMC) provide numerous therapeutic advantages, but pose significant analytical challenges during the assay of polar active substances due to the polymer's high swelling capacity and gel-forming behaviour. This study aims to…
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Osteoporosis and reproductive health
Osteoporosis is a prevalent issue among menopausal women; however, the number of women with risk factors across all age groups is increasing. This trend can lead to the development of osteopenia or osteoporosis at a younger age, significantly impacting women's physical, emotional, and mental…
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Women's experiences with antibiotic use in urinary tract infections: Insights from the patient's perspective
From patients' perspective, the use of antibiotics to treat urinary tract infections (UTIs) in Serbia is unexplored, and therefore the aim of this study is to examine antibiotic use among these patients. An online cross-sectional study using snowball sampling was conducted during the winter of…
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Pharmacovigilance and adverse drug reaction reporting in primary, secondary, and tertiary healthcare: A review of practices, challenges, and recommendations
According to the World Health Organization, pharmacovigilance is a science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. Since the underreporting of adverse drug reactions (ADRs) remains a significant global…
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Pneumococcal vaccination in older adults: A useful, but underused weapon
Streptococcus pneumoniae is a Gram-positive coccus with a characteristic oval shape, microscopically most often grouped in pairs (diplococci). It is encapsulated microorganism responsible for a variety of infections in humans, which can be categorized into non-invasive and invasive forms. Although…
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Influence of immortelle (Helichrysum italicum (Roth) G. Don) and lavender (Lavandula angustifolia Mill.) hydrolates on oxidative stress and antioxidative parameters in human serum
A number of studies suggest that different antioxidants play important roles in the body's antioxidant defense system. Hydrolates, by-products of essential oils, commonly obtained by steam distillation, are recognized to possess remarkable pharmacological activities, in particular an antioxidant…
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Perceived role of pharmacists in managing home-based pharmaceutical services in Norway: An interview study with community pharmacists
Pharmacists have the potential to address gaps in primary healthcare by providing pharmaceutical services in home care settings, particularly in response to the challenges faced by the Norwegian healthcare system. Their integration into primary care teams could enhance care quality, reduce the…
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Biomarkers of menopause
Natural menopause is defined as the permanent cessation of menstruation resulting from the loss of ovarian follicular activity. This significant phase in women's reproductive aging has notable effects on fat distribution, dyslipidemia, and neurodegeneration. These changes contribute to an increased…