12 results
Showing 1–12 · 0.35 seconds · RSS
Genetics
Scopus
ISSN 0016-6731 · Oxford University Press · 12 articles in the index
-
Journal Article Full text
FlyBase: updates to the Drosophila genes and genomes database
FlyBase (flybase.org) is a model organism database and knowledge base about Drosophila melanogaster, commonly known as the fruit fly. Researchers from around the world rely on the genetic, genomic, and functional information available in FlyBase, as well as its tools to view and interrogate these…
-
Journal Article Full text
WormBase 2024: status and transitioning to Alliance infrastructure
WormBase has been the major repository and knowledgebase of information about the genome and genetics of Caenorhabditis elegans and other nematodes of experimental interest for over 2 decades. We have 3 goals: to keep current with the fast-paced C. elegans research, to provide better integration…
-
Journal Article Full text
Mouse Genome Informatics: an integrated knowledgebase system for the laboratory mouse
Mouse Genome Informatics (MGI) is a federation of expertly curated information resources designed to support experimental and computational investigations into genetic and genomic aspects of human biology and disease using the laboratory mouse as a model system. The Mouse Genome Database (MGD) and…
-
Journal Article Full text
The Gene Ontology knowledgebase in 2023
The Gene Ontology (GO) knowledgebase (http://geneontology.org) is a comprehensive resource concerning the functions of genes and gene products (proteins and noncoding RNAs). GO annotations cover genes from organisms across the tree of life as well as viruses, though most gene function knowledge…
-
Journal Article Full text
WormBase in 2022—data, processes, and tools for analyzing Caenorhabditis elegans
WormBase (www.wormbase.org) is the central repository for the genetics and genomics of the nematode Caenorhabditis elegans. We provide the research community with data and tools to facilitate the use of C. elegans and related nematodes as model organisms for studying human health, development, and…
-
Journal Article Full text
FlyBase: a guided tour of highlighted features
FlyBase provides a centralized resource for the genetic and genomic data of Drosophila melanogaster. As FlyBase enters our fourth decade of service to the research community, we reflect on our unique aspects and look forward to our continued collaboration with the larger research and model organism…
-
Journal Article Full text
Zebrafish information network, the knowledgebase for Danio rerio research
The Zebrafish Information Network (zfin.org) is the central repository for Danio rerio genetic and genomic data. The Zebrafish Information Network has served the zebrafish research community since 1994, expertly curating, integrating, and displaying zebrafish data. Key data types available at the…
-
Journal Article Full text
Efficient ancestry and mutation simulation with msprime 1.0
Stochastic simulation is a key tool in population genetics, since the models involved are often analytically intractable and simulation is usually the only way of obtaining ground-truth data to evaluate inferences. Because of this, a large number of specialized simulation programs have been…
-
Journal Article Full text
Assessing the performance of qpAdm: a statistical tool for studying population admixture
qpAdm is a statistical tool for studying the ancestry of populations with histories that involve admixture between two or more source populations. Using qpAdm, it is possible to identify plausible models of admixture that fit the population history of a group of interest and to calculate the…
-
Journal Article Full text
Phylogenomic approaches to detecting and characterizing introgression
Phylogenomics has revealed the remarkable frequency with which introgression occurs across the tree of life. These discoveries have been enabled by the rapid growth of methods designed to detect and characterize introgression from whole-genome sequencing data. A large class of phylogenomic methods…
-
Journal Article Full text
Melting dsDNA Donor Molecules Greatly Improves Precision Genome Editing in Caenorhabditis elegans
Abstract Melting and fast cooling double stranded DNA donor molecules prior to injection dramatically increases the frequency of homology-directed repair for edits such as insertions of fluorescent protein markers in Caenorhabditis elegans. Strategies described here enable consistently .....
-
Journal Article
Phenotypic Plasticity: From Theory and Genetics to Current and Future Challenges
Abstract Phenotypic plasticity is defined as the property of organisms to produce distinct phenotypes in response to environmental variation. While for more than a century, biologists have proposed this organismal feature... Phenotypic plasticity is defined as the property of organisms to produce…