13.067 hasil
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Journal of Lipid Research
Scopus
ISSN 0022-2275 · Elsevier · 13.067 artikel di indeks
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Artikel Jurnal
Targeted PPARδ activation reprograms microglial immunometabolism and improves insulin sensitivity in HFD-fed rats
Microglia lipid metabolism plays a crucial role in maintaining immune function and supporting neuronal health. Previous studies have shown that a high-fat diet (HFD) promotes lipid accumulation in microglia, while disruption of lipid uptake and utilization impair neuroimmune competency and…
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Artikel Jurnal
Mechanisms of scramblases in regulating hepatic lipoprotein secretion and autophagy
Lipoprotein secretion is a complex, highly regulated multi-step process that ensures the efficient transport of lipids from cells into the bloodstream, supporting overall metabolic health. The secretion of very-low-density lipoprotein (VLDL) relies on the proper assembly and movement of…
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Analytical validation of monoclonal antibody-based ELISA methods for OxPL-apoB and OxPL-apo(a)
Oxidized phospholipids (OxPL) are bioactive lipid species that circulate bound to apolipoprotein B-100 [apoB] and apolipoprotein(a) [apo(a)] and have been widely studied as biomarkers of oxidative lipid burden. When bound to apolipoprotein B-100 [OxPL-apoB] and apolipoprotein(a) [OxPL-apo(a)], they…
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COP9 signalosome is required for adipose tissue maintenance and metabolic health
Constitutive photomorphogenesis mutant 9 (COP9) signalosome (CSN) is composed of eight subunits (CSN1 through CSN8). It acts as an essential regulator of Cullin-RING-ubiquitin ligases (CRLs), which target critical cellular regulators for degradation via the ubiquitin (Ub) proteasome pathway. The…
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KLF7 induced ADRB3-dependent IL-6 production in brown adipocytes during stress
In recent studies, acute physiological stress has been shown to enhance liver gluconeogenesis by activating β3-adrenergic receptor (ADRB3)-dependent interleukin-6 (IL-6) production in brown adipocytes, effectively fueling “fight or flight” responses. However, the specific molecular mechanism of…
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Tryptophan and polyamine metabolism dysregulation serves as an early marker of high-fat diet-induced glucose intolerance
A high-fat diet (HFD) induces metabolic dysfunction early, before the onset of the classic obese phenotype. However, understanding this early process remains limited, and potential diagnostic systems are still poorly investigated, particularly in childhood obesity. Continuous blood glucose…
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The n-3 PUFA content of the global lipidomes of NIST SRM 2378, SRM 1950, and intralaboratory quality control materials
The regular use of commercially available Standard Reference Materials (SRM) and intralaboratory quality control materials, which are important tools, is essential for standardizing and ensuring high-quality lipidomic analyses. These materials should also be relevant for the research application…
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Improved preanalytical workflow for pancreatic tissue lipidomics: insights into lipid stability and polar lipid recovery
Tissue lipidomics is a rapidly advancing field in clinical and biomedical research that provides crucial information on the lipid-driven molecular mechanisms underlying physiological and pathological conditions. However, accurate MS-based analysis requires careful preanalytical handling due to the…
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Phospholipase A2 products influence the antiplatelet functions of synthetic high-density lipoproteins
Multiple synthetic high-density lipoproteins (sHDLs) have been developed and extensively evaluated in preclinical and clinical trials, with their functionality potentially linked to specific lipid compositions. This study investigates how lipid composition influences sHDL interactions with…
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High cholesterol absorption efficiency increases the risk of the nonfatal and fatal atherosclerotic events
The aim of this study was to investigate whether cholesterol metabolism, especially high cholesterol absorption, affects atherosclerotic event risk in acute coronary syndrome (ACS) versus control patients without coronary artery disease (CAD). We set up a randomized, case-control substudy of a…
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Artikel Jurnal
Phosphatidylcholine with C26:0 moiety, a precursor of a diagnostic marker for X-ALD, is synthesized by LPLAT10/LPEAT2
X-linked adrenoleukodystrophy (X-ALD) is a congenital metabolic disorder characterized mainly by inflammatory demyelination and adrenal insufficiency. Newborn screening using hexacosanoyl lysophosphatidylcholine (C26:0-LPC) in dried blood spots as a diagnostic marker can successfully identify…
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Chronic kidney disease induces distinct alterations of macrophage lipid metabolism in a mouse model of atherosclerosis
Chronic kidney disease (CKD) is associated with altered lipid metabolism and chronic inflammation, which both contribute to an accelerated risk of atherosclerotic cardiovascular disease. Macrophage polarization towards a pro-inflammatory phenotype plays a key role in atherosclerotic cardiovascular…
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Characterization of posttranslational modification in metabolic dysfunction-associated steatohepatitis: acetylation, lactylation, and phosphorylation
In metabolic dysfunction-associated steatohepatitis (MASH), abnormalities in posttranslational modification (PTM) are both a consequence of the pathological process and a driving force for disease progression. Therefore, this study intends to characterize the PTM features (acetylation, lactylation…
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Site-specific cholesterol depletion therapy for gastric cancer
Altered cholesterol metabolism is a recognized hallmark of cancer, but systemic modulation has not yet delivered significant clinical results. Accumulating evidence shows that cholesterol plays distinct roles across diverse cellular membranes, suggesting that site-specific modulation may produce…
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Adipose-specific
Appropriate adipose tissue deposition plays a critical role in regulating systemic energy metabolic homeostasis. Epigenetic mechanisms have emerged as critical modulators of these processes; however, the role of specific histone demethylases in adipocytes remains poorly understood. Here, we…
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Erythrocyte membrane lipid remodeling in high-altitude polycythemia and after therapeutic erythrocytapheresis
High-altitude polycythemia (HAPC) remains prevalent among Tibetans despite genetic adaptations, including EPAS1/HIF2A. Excessive erythrocytosis elevates blood viscosity and increases cardiopulmonary risk, yet erythrocyte metabolic and membrane-lipid mechanisms of HAPC and of therapeutic…
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Artikel Jurnal
Chronic high-fat diet feeding reduces the rate of postprandial triglyceride absorption independent of intestinal ANGPTL4
Pancreatic lipase is the major enzyme responsible for breaking down dietary triglycerides in the intestines. A previous report suggested that intestinal angiopoietin-like 4 (ANGPTL4) might serve as an endogenous inhibitor of pancreatic lipase and thus regulate fat absorption. As Angptl4 expression…
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LOX-mediated adipose tissue stiffening promotes weight rebound
Weight rebound remains the core challenge in the long-term management of obesity. Although current mechanistic understanding mainly focuses on physiological adaptations, the role of biomechanical factors remains largely unexplored. This study aims to investigate the contribution of lysyl oxidase…
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