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Nature
Scopus
ISSN 0028-0836 · Nature Portfolio · 1.376 artikel di indeks
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Artikel Jurnal
Advancing regulatory variant effect prediction with AlphaGenome
Abstract Deep learning models that predict functional genomic measurements from DNA sequences are powerful tools for deciphering the genetic regulatory code. Existing methods involve a trade-off between input sequence length and prediction resolution, thereby limiting their modality scope and…
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A generative model for inorganic materials design
Abstract The design of functional materials with desired properties is essential in driving technological advances in areas such as energy storage, catalysis and carbon capture 1–3 . Generative models accelerate materials design by directly generating new materials given desired property…
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Impacts of climate change on global agriculture accounting for adaptation
Climate change threatens global food systems1, but the extent to which adaptation will reduce losses remains unknown and controversial2. Even within the well-studied context of US agriculture, some analyses argue that adaptation will be widespread and climate damages small3,4, whereas others…
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RETRACTED ARTICLE: Warming accelerates global drought severity
Abstract Drought is one of the most common and complex natural hazards affecting the environment, economies and populations globally 1–4 . However, there are significant uncertainties in global drought trends 4–6 , and a limited understanding of the extent to which a key driver, atmospheric…
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The distribution of subsurface microplastics in the ocean
Marine plastic pollution is a global issue, with microplastics (1 µm–5 mm) dominating the measured plastic count1,2. Although microplastics can be found throughout the oceanic water column3,4, most studies collect microplastics from surface waters (less than about 50-cm depth) using net tows5…
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One-quarter of freshwater fauna threatened with extinction
Abstract Freshwater ecosystems are highly biodiverse 1 and important for livelihoods and economic development 2 , but are under substantial stress 3 . To date, comprehensive global assessments of extinction risk have not included any speciose groups primarily living in freshwaters. Consequently…
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The global human impact on biodiversity
Abstract Human activities drive a wide range of environmental pressures, including habitat change, pollution and climate change, resulting in unprecedented effects on biodiversity 1,2 . However, despite decades of research, generalizations on the dimensions and extent of human impacts on…
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Global evolution of inflammatory bowel disease across epidemiologic stages
During the twentieth century, inflammatory bowel disease (IBD) was considered a disease of early industrialized regions in North America, Europe and Oceania1. At the turn of the twenty-first century, IBD incidence increased in newly industrialized and emerging regions in Africa, Asia and Latin…
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Immune evasion through mitochondrial transfer in the tumour microenvironment
Cancer cells in the tumour microenvironment use various mechanisms to evade the immune system, particularly T cell attack1. For example, metabolic reprogramming in the tumour microenvironment and mitochondrial dysfunction in tumour-infiltrating lymphocytes (TILs) impair antitumour immune…
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Towards conversational diagnostic artificial intelligence
Abstract At the heart of medicine lies physician–patient dialogue, where skillful history-taking enables effective diagnosis, management and enduring trust 1,2 . Artificial intelligence (AI) systems capable of diagnostic dialogue could increase accessibility and quality of care. However…
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RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancer
A fundamental challenge for cancer vaccines is to generate long-lived functional T cells that are specific for tumour antigens. Here we find that mRNA–lipoplex vaccines against somatic mutation-derived neoantigens may solve this challenge in pancreatic ductal adenocarcinoma (PDAC), a lethal cancer…
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Accurate predictions on small data with a tabular foundation model
Abstract Tabular data, spreadsheets organized in rows and columns, are ubiquitous across scientific fields, from biomedicine to particle physics to economics and climate science 1,2 . The fundamental prediction task of filling in missing values of a label column based on the rest of the columns is…
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DeepSeek-R1 incentivizes reasoning in LLMs through reinforcement learning
Abstract General reasoning represents a long-standing and formidable challenge in artificial intelligence (AI). Recent breakthroughs, exemplified by large language models (LLMs) 1,2 and chain-of-thought (CoT) prompting 3 , have achieved considerable success on foundational reasoning tasks. However…
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Activation of lysosomal iron triggers ferroptosis in cancer
Iron catalyses the oxidation of lipids in biological membranes and promotes a form of cell death called ferroptosis1. Defining where this chemistry occurs in the cell can inform the design of drugs capable of inducing or inhibiting ferroptosis in various disease-relevant settings. Genetic…
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RETRACTED ARTICLE: The economic commitment of climate change
Abstract Global projections of macroeconomic climate-change damages typically consider impacts from average annual and national temperatures over long-time horizons. Here, we utilize recent empirical findings from more than 1600 regions worldwide over the past 40 years to project sub-national…
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A small and vigorous black hole in the early Universe
Abstract Several theories have been proposed to describe the formation of black hole seeds in the early Universe and to explain the emergence of very massive black holes observed in the first thousand million years after the Big Bang 1–3 . Models consider different seeding and accretion scenarios…
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Acceleration of radiative recombination for efficient perovskite LEDs
Abstract The increasing demands for more efficient and brighter thin-film light-emitting diodes (LEDs) in flat-panel display and solid-state lighting applications have promoted research into three-dimensional (3D) perovskites. These materials exhibit high charge mobilities and low quantum…
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