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Immunological Reviews
Scopus
ISSN 0105-2896 · Wiley · 10 artikel di indeks
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Artikel Jurnal Teks lengkap
Immunological memory to SARS‐CoV ‐2 infection and COVID ‐19 vaccines
Immunological memory is the basis of protective immunity provided by vaccines and previous infections. Immunological memory can develop from multiple branches of the adaptive immune system, including CD4 T cells, CD8 T cells, B cells, and long-lasting antibody responses. Extraordinary progress has…
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Artikel Jurnal
Correlates of protection against SARS ‐ CoV ‐2 infection and COVID‐19 disease
Abstract Antibodies against epitopes in S1 give the most accurate CoP against infection by the SARS‐CoV‐2 coronavirus. Measurement of those antibodies by neutralization or binding assays both have predictive value, with binding antibody titers giving the highest statistical correlation. However…
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Artikel Jurnal Teks lengkap
COVID‐19 and pulmonary fibrosis: A potential role for lung epithelial cells and fibroblasts
The COVID-19 pandemic rapidly spread around the world following the first reports in Wuhan City, China in late 2019. The disease, caused by the novel SARS-CoV-2 virus, is primarily a respiratory condition that can affect numerous other bodily systems including the cardiovascular and…
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Cancer‐associated fibroblasts: Key players in shaping the tumor immune microenvironment
Cancer immunotherapies have rapidly changed the therapeutic landscape for cancer. Nevertheless, most of the patients show innate or acquired resistance to these therapies. Studies conducted in recent years have highlighted an emerging role of cancer-associated fibroblasts (CAFs) in immune…
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Artikel Jurnal
The molecular mechanism of RIG‐I activation and signaling
RIG-I is our first line of defense against RNA viruses, serving as a pattern recognition receptor that identifies molecular features common among dsRNA and ssRNA viral pathogens. RIG-I is maintained in an inactive conformation as it samples the cellular space for pathogenic RNAs. Upon encounter…
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Artikel Jurnal
Role of cancer‐associated fibroblast subpopulations in immune infiltration, as a new means of treatment in cancer
The tumor microenvironment (TME) has been identified as one of the driving factors of tumor progression and invasion. Within this microenvironment, cancer-associated fibroblasts (CAF) have multiple tumor-promoting functions and play key roles in drug resistance, through multiple mechanisms…
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Artikel Jurnal Teks lengkap
Immunometabolism: From basic mechanisms to translation
Immunometabolism has emerged as a major mechanism central to adaptive and innate immune regulation. From early observations that inflammatory cytokines were induced in obese adipose tissue and that these cytokines contributed to metabolic disease, it was clear that metabolism and the immunological…
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The regulation of the ZBP1‐NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis)
ZBP1 has been characterized as a critical innate immune sensor of not only viral RNA products but also endogenous nucleic acid ligands. ZBP1 sensing of the Z-RNA produced during influenza virus infection induces cell death in the form of pyroptosis, apoptosis, and necroptosis (PANoptosis)…
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Artikel Jurnal
AIM2 in health and disease: Inflammasome and beyond
Nucleic acid sensing is a critical mechanism by which the immune system monitors for pathogen invasion. A set of germline-encoded innate immune receptors detect microbial DNA in various compartments of the cell, such as endosomes, the cytosol, and the nucleus. Sensing of microbial DNA through these…
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Artikel Jurnal Teks lengkap
The role of host genetics in the immune response to SARS‐CoV‐2 and COVID‐19 susceptibility and severity
This article provides a review of studies evaluating the role of host (and viral) genetics (including variation in HLA genes) in the immune response to coronaviruses, as well as the clinical outcome of coronavirus-mediated disease. The initial sections focus on seasonal coronaviruses, SARS-CoV, and…