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Environment International
Scopus
ISSN 0160-4120 · Elsevier · 6.282 artikel di indeks
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Artikel Jurnal
A chemical space model for the exploration of eco-toxicological data
With over 350,000 chemicals and mixtures currently registered for production and use worldwide, around 83% of authorized chemicals lack adequate toxicity data, leaving the majority of chemicals poorly characterized. International agencies urge scientists to develop screening methods to explore…
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Artikel Jurnal
Co-exposure to PFOA, PFBA and nanoplastics synergistically exacerbates neurotoxicity by impairing PINK1/Parkin-mediated mitophagy
Perfluorooctanoic acid (PFOA) and perfluorobutyric acid (PFBA), as representative long-chain and short-chain per- and polyfluoroalkyl substances (PFAS), are widely distributed in the environment. These compounds can interact with nanoplastics (NPs) to form complex mixed pollutants, posing potential…
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Artikel Jurnal
Black carbon and psychosocial stress synergistically impair cardiovascular function via hippocampal glucocorticoid receptor methylation
Black carbon (BC), a key toxic constituent of ambient PM2.5, and psychosocial stress, heightened by socioeconomic instability, both impair cardiovascular health. While epidemiological studies suggest that psychosocial stress could amplify the cardiovascular risks associated with air pollution…
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Artikel Jurnal
Identification of potential mechanisms of cognitive dysfunction induced by environmentally relevant PFAS mixture in male rats
PFAS are emerging persistent organic pollutants, and their potential impacts and underlying mechanisms on cognitive function remain incompletely understood. This study utilized a male rat model to investigate the effects of an environmentally relevant PFAS mixture comprised of eight PFAS on spatial…
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Artikel Jurnal
Identification of pesticides associated with an increased risk of Parkinson’s disease using a multi-screen approach
Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by aggregation and transmission of alpha-synuclein (α-syn) protein and loss of dopaminergic neurons. The etiology of PD is multifactorial, involving both genetic and environmental factors. Pesticide exposure has been…
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Artikel Jurnal
Synergistic disruption of blood-brain barrier and neuroimmune homeostasis by sleep-related environmental pollutants drives sleep disorders: an integrated computational and experimental study
Environmental pollutants are increasingly linked to sleep disorders (SD), affecting 27% of people globally, yet their synergistic effects remain understudied. Network toxicology identified 252 shared targets between sleep-related environmental pollutants (SREPs: NO2, formaldehyde, benzene) and SD…
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Artikel Jurnal
Flow conditions govern the efficiency of passive environmental DNA sampling
Effective aquatic biomonitoring requires understanding how flow conditions influence the efficiency of environmental DNA (eDNA) sampling, particularly where conventional filtration is slow or impractical. Passive eDNA samplers (PEDS), which accumulate DNA on submerged substrates, offer a low-effort…
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Artikel Jurnal
Toward integrating subjective well-being in environmental health impact assessments for healthy urban living: a conceptual and methodological exploration
Introduction: Environmental Health Impact Assessments (HIAs) can inform decisions about the health effects of policy-related changes in environmental exposures. Conventional health impact metrics, focusing on mortality, morbidity, and disability, neglect subjective well-being. We explored the need…
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Artikel Jurnal
Sodium hypochlorite residual in the environment facilitated the spread of antibiotic resistance genes: through microplastics as a medium
Most pollutants in the environment exist in complex forms, and exploring the impact of a single pollutant lacks wide applicability. The co-exposure of microplastics (MPs) and NaClO in wastewater treatment plants (WWTPs) is a widespread occurrence. At present, relevant reports on the impact of…
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Artikel Jurnal
Prenatal greenness, air pollution, and birthweight: Assessing sensitive windows of exposure and sub-populations in a multi-exposure setting
Introduction: Studies show that prenatal neighborhood greenness is positively associated with birthweight. However, few go beyond a pregnancy-long greenness average or consider air pollution co-exposures. We used time-varying greenness and air pollution estimates to explore sensitive windows and…
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Artikel Jurnal
Human blood concentrations of perfluoroalkyl substances resulting from consumption of contaminated meat in Korsør, Denmark
Background: In 2021 analyses of veal revealed elevated concentrations of the per- and polyfluorinated alkyl substances (PFAS), perfluorooctanesulfonic acid (PFOS) and perfluorohexanesulfonic acid (PFHxS). Each year since 1999, the calves had consumed grass and water near a firefighting school in…
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Artikel Jurnal
A benchmark dose analysis of the blood cadmium concentration in pregnant women using the Japan Environment and Children’s Study data
Background and aim: A safe blood cadmium (Cd) level for pregnant women, in relation to infant birth weight, has not been established; therefore, we aimed to determine a benchmark dose (BMD) for blood Cd in pregnant women using the BMD approach. Methods: We used data from 80,669 mother–child pairs…
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Artikel Jurnal
Insights from an invited expert panel using a World Café: Establishing a national human biomonitoring programme communication strategy
Human biomonitoring (HBM) is a pivotal tool for assessing chemical exposures and guiding regulatory decisions to safeguard public and environmental health, particularly within the framework of the European Union’s Chemicals Strategy for Sustainability and other EU policies for chemical safety…
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Artikel Jurnal
Gestational exposure to metals and small vulnerable newborns: a systematic review and meta-analysis
Background: Small vulnerable newborns (SVNs), defined as babies affected by preterm birth (PTB), small for gestational age (SGA), or low birth weight (LBW), face a substantially increased risk of chronic diseases over their lifespan and premature mortality. Gestational exposure to heavy metals may…
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Artikel Jurnal
Endogenous 15(S)-hydroxyeicosatetraenoic acid mediates amplified estrogenic responses under nanoplastic–homosalate coexposure
Micro- and nanoplastics (MNPs) can enhance the toxicity of co-occurring chemicals via a proposed “Trojan horse” effect, yet the underlying mechanisms remain unclear. Here, we investigated the estrogenic effects of coexposure of ultraviolet filter homosalate (HMS) and polystyrene nanosphere (PNS)…
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Artikel Jurnal
Ecotoxicity effects on functional diversity – A proof of concept using a sensitivity distribution approach
Current approaches for estimating the effects of chemical exposure commonly rely on species sensitivity distributions, which are well-established in ecotoxicological assessments for chemical registration and authorisation. However, this method does not consider the functional roles of species…
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Artikel Jurnal
Prioritizing steatogenic chemicals through integration ToxCast™ data, machine learning, and experimental validation
As hepatic steatosis driven by environmental exposures increasingly contributes to the global burden of metabolic disease, identifying and prioritizing high-potency steatogenic chemicals is critical for enabling risk-oriented toxicological and environmental regulation. Leveraging the…
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Artikel Jurnal
Longitudinal associations of long-term exposure to ambient air pollution, residential greenness, and air temperature with type 2 diabetes subphenotypes: Results from the KORA cohort study
Objective: To examine the association between environmental exposures and specific type 2 diabetes (T2D) subphenotypes. Research design and methods: We categorized T2D participants from the KORA F4 (2006–2008) and FF4 (2013–2014) study waves into three phenotypes using k-means clustering: Cluster A…
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Artikel Jurnal
Prenatal exposure to persistent organic pollutants modulates the metabolism and gut microbiota of the offspring
Emerging evidence suggests that environmental contaminants can influence both human metabolism and gut microbiota composition. However, the specific effects of prenatal exposure to persistent organic pollutants (POPs) on host–microbiome metabolic interactions remain incompletely understood. In this…
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Artikel Jurnal
Pesticides associated with incident diabetes among licensed private pesticide applicators in the Agricultural Health Study cohort (1993–2021)
Background: Growing evidence suggests pesticides may increase risk of type 2 diabetes, but data are limited on many specific chemicals. Methods: In 29,527 private pesticide applicators in the Agricultural Health Study cohort (enrolled 1993–1997 in Iowa and North Carolina), 3,847 incident diabetes…
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