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Immunobiology
Scopus
ISSN 0171-2985 · Elsevier · 188 artikel di indeks
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Artikel Jurnal
Screening of kinase-related genes as diagnostic biomarkers and immune infiltration analysis in sepsis
Background: Sepsis is a systemic inflammatory syndrome that can lead to loss of organ function. Kinase-related genes (KRGs) modulate immune diseases by regulating inflammation, immune metabolism, and apoptosis. However, their specific role in Sepsis remains unexplored. Methods: mRNA and single-cell…
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Artikel Jurnal
Cytokine-induced killer (CIK) cells inhibit Plasmodium falciparum parasitemia through cytolytic effector activity in vitro
Cytokine-induced killer (CIK) cells, with dual traits resembling natural killer (NK) and T cells, have shown a promising clinical efficacy against cancer in clinical application leading to licensing of CIK cells in many countries. Here, we demonstrated that CIK cells can also inhibit the growth of…
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Chlamydia psittaci inclusion membrane protein CPSIT_0844 elicits inflammatory IL-6 and IL-8 production in human monocytes via TLR2/TLR4 signaling pathways
The respiratory disease caused by Chlamydia psittaci (C. psittaci) infection is often characterized by significant inflammation. In the present study, we demonstrated that the C. psittaci inclusion membrane protein CPSIT_0844 induced THP-1 cells to express IL-6 and IL-8. However, silencing of the…
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Cell-free supernatant of Clostridium butyricum induces mitochondrial apoptosis and suppresses NF-κB pathway in colorectal cancer cells
Background: Clostridium butyricum (CB), a butyrate-producing probiotic, exhibits antitumor potential in colorectal cancer (CRC). This study investigated the direct effects and mechanisms of CB-secreted metabolites on CRC cells. Methods: HT-29 cells were treated with serial dilutions (5–40%) of…
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Artikel Jurnal
BCL3 drives an immunosuppressive tumor microenvironment in esophageal cancer by promoting M2 macrophage polarization via STAT3 activation
Introduction: The progression of esophageal cancer is closely linked to the establishment of an immunosuppressive tumor microenvironment. Although B-cell leukemia/lymphoma 3 (BCL3) is dysregulated in various cancers, its specific role and mechanism in shaping the immune microenvironment of…
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Recombination-center ablation of
Genetic disruption of immunoglobulin loci has long established the requirement for heavy- and light-chain rearrangement during B-cell development. Here, we generated Igh -KO, Igκ -KO, and Igh/Igκ double-KO mice by CRISPR/Cas9-mediated deletion of essential recombination-center elements and…
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Tangeretin ameliorates hypertriglyceridemic acute pancreatitis by restoring Th17/Treg balance via ROS-mediated STAT3 signaling
Objective: The mechanisms underlying the progression of hypertriglyceridemic acute pancreatitis (HTGP), particularly CD4 + T cell–mediated immune dysregulation, remain poorly understood. Methods: To address this issue, clinical data and peripheral blood samples from patients with acute pancreatitis…
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Impact of obesity on LAG-3 and CTLA-4 expression in CD4
Obesity is increasingly recognized as a metabolic factor influencing immune regulation in sarcoidosis (SA). This study examined whether obesity alters immune-checkpoint expression on lymph-node–resident T cells in newly diagnosed, treatment-naïve SA patients. Sixty-three individuals underwent…
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Exploring the mechanism underlying negative pressure wound therapy in promoting the healing of diabetic foot ulcers via integrated multi-omics and bioinformatics approaches
Background: Diabetic foot ulcers (DFU) are one of the most serious complications of diabetes, closely associated with high amputation rates, mortality, and healthcare burdens, and the clinical treatment research is still limited. Negative Pressure Wound Therapy (NPWT) is a treatment modality for…
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Artikel Jurnal
Ketone ester alleviates sepsis-associated liver injury through β-hydroxybutyrylation of STAT1
Sepsis-associated liver injury is characterized by excessive inflammation and macrophage activation. β-Hydroxybutyrate (β-OHB) has anti-inflammatory effects and induces lysine β-hydroxybutyrylation (Kbhb), but the role of site-specific Kbhb in septic liver injury remains unclear. This study…
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Differential parental exposure to polystyrene microplastics from weaning period to maturity: Immune homeostasis dysregulation in F1 offspring
The effects of long-term parental microplastic exposure on offspring immunity remain unclear. This study investigated how different parental exposure patterns affect immune status in F1 offspring. Parental rats were divided into four groups: paternal, maternal, dual-parental, and control. Treated…
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Transcriptomic profiling reveals complement activation in chronic pancreatitis adjacent to pancreatic ductal adenocarcinoma
Chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC) frequently coexist, yet distinguishing inflammatory changes secondary to malignancy from primary pancreatitis remains challenging. Here, we present an integrated multi-omics analysis of spatially distinct pancreatic tissue…
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Artikel Jurnal
Luhong formula attenuates cardiomyocyte hypoxia/reoxygenation injury in vitro through SLC7A11-mediated ferroptosis
This study investigates whether Luhong Formula (LHF) inhibits hypoxia/reoxygenation (H/R)-induced ferroptosis in cardiomyocytes and the underlying mechanism. H9c2 cells were subjected to H/R injury and treated with LHF extract, diltiazem (positive control), or Fer-1 (ferroptosis inhibitor). CCK-8…
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A fusion protein of the two tick-derived C5 inhibitors OmCI and RaCI: complete C5 inhibition despite strong complement activation
The complement system must be tightly regulated to prevent tissue damage and disease, yet current C5 inhibitors like the anti-C5 monoclonal antibody Eculizumab – though clinically approved ( e.g. , for paroxysmal nocturnal haemoglobinuria, PNH) - fail to achieve complete terminal pathway blockade…
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The CCL2-CCR2-Ly6c + macrophage axis in PegIFNα-2b therapy for chronic hepatitis B
Background: Interferon (IFN) is an important treatment for chronic hepatitis B (CHB), with highly variable clinical efficacy, and how IFN-α mediates its therapeutic benefits via innate immunity, particularly macrophages, is not fully understood. Objectives: To elucidate whether and how the…
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ECMO-assisted whole lung lavage combined with GM-CSF inhalation for severe pulmonary alveolar proteinosis: a comparative cohort study
Purpose: This study evaluated the association of combining veno-venous extracorporeal membrane oxygenation (ECMO) with whole-lung lavage (WLL) and granulocyte-macrophage colony-stimulating factor (GM-CSF) nebulization in pulmonary alveolar proteinosis (PAP), focusing on pulmonary function…
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m6A writer METTL14 restricts
N6-methyladenosine (m6A) modification plays a crucial role in regulating immune responses against Mycobacterium tuberculosis (Mtb) infection, but the underlying mechanisms remain unclear. Here, we analyzed m6A regulatory gene expression in GEO dataset GSE139825 and validated the finding in…
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Artikel Jurnal
Integrative multi-omics analysis identifies AIF1 as an immune-associated factor linked to monocyte-centered inflammatory networks in Alzheimer's disease
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder in which immune dysregulation has emerged as an important component of disease pathogenesis; however, the contribution of circulating proteins and their cellular context remains incompletely understood. Here, we performed an…
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Mesenchymal stem cell-derived small extracellular vesicles alleviate LPS-induced myocardial injury via the microRNA-23a-3p/BNIP3L pathway
Sepsis-induced myocardial injury is a critical condition with limited therapeutic options. This study investigates the therapeutic potential of mesenchymal stem cell (MSC)-derived small extracellular vesicles (MEx) in lipopolysaccharide (LPS)-induced myocardial injury in rat model and explores the…
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Artikel Jurnal
The effect of storage time on lymphocytes function detection: Application in clinical samples
Due to the complexity of clinical work, some blood samples for lymphocyte activity detection might be conducted thrice weekly rather than daily. Whether the levels of cytokines secreted by lymphocytes are affected by storage time of blood samples has not been studied. In clinical work, we found…