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European Journal of Cell Biology
Scopus
ISSN 0171-9335 · Elsevier · 361 artikel di indeks
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Artikel Jurnal
Response of the bovine oviduct epithelium to sperm binding and proximity: a region-specific proteomic approach using spheroids
Following uterine migration, spermatozoa reach the isthmus, where a subpopulation binds to luminal oviduct epithelial cells (OECs) to establish a functional reservoir. From there, spermatozoa continue towards the ampulla, maintaining interactions with OECs prior to fertilization. This study…
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Artikel Jurnal
TGF-β drives pulmonary fibrosis through dual dysregulation of TNF pathway transcription and splicing
It is well known that TGF-β plays a key role in the progression of pulmonary fibrosis. However, how TGF-β/SMAD3 regulates downstream effector genes and its effect on alternative splicing in pulmonary fibrosis is still not fully understood. Here, we established a TGF-β-induced pulmonary fibrosis…
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DAPK1 orchestrates cell division and junction to control corneal epithelial development
Stratification of the corneal epithelium plays a vital role in protecting the eye from the external stimuli. However, the molecular mechanisms underlying this process are not fully understood. Herein, we show that death-associated protein kinase 1 (DAPK1) is markedly up-regulated during corneal…
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Integrin β1 mediates mechanosensitive regulation of human trabecular meshwork cell functions in response to substrate stiffness
Increased extracellular matrix (ECM) stiffness is a well-recognized pathological hallmark of the trabecular meshwork (TM) in glaucomatous eyes; however, the mechanotransductive pathways by which TM cells sense and respond to mechanical cues remain incompletely understood. In this study, we…
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Artikel Jurnal
ATF3: Friend or foe in cellular stress and repair? A context-dependent stress rheostat framework
Activating transcription factor 3 (ATF3) is an immediate-early basic leucine zipper transcription factor induced by diverse forms of cellular stress. Although ATF3 is often described as a “double-edged sword,” that formulation alone does not explain why the same stress-responsive factor can…
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Artikel Jurnal
Mitochondria-associated programmed cell death in colorectal cancer: molecular mechanisms, metabolic plasticity, and therapeutic opportunities
Mitochondria integrate bioenergetics, redox homeostasis, calcium signaling, metabolite synthesis, organelle quality control, innate immune sensing, and regulated cell death. In colorectal cancer (CRC), mitochondrial function is not simply suppressed by aerobic glycolysis; rather, tumor cells…
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Timeline of sex differentiation and stabilization in zebrafish: Interplay between methyl-sensitive transcription factors, prostaglandin-related genes and DNA methylation
The processes by which an individual develops as a male (testis) or female (ovary) are remarkably diverse across taxa. While sex is determined by genetic factors in some species, it can be determined by environmental factors in others. Despite these discrepancies, common features are however…
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Exploring the impact of syndecans in prostate cancer: Stage-specific roles and therapeutic implications
Syndecans (SDCs) 1–4 are a family of transmembrane heparan sulfate proteoglycans (HSPGs) that regulate cell–cell communication, adhesion, extracellular matrix organization, and signaling pathways involved in tumor biology. In prostate cancer (PCa), accumulating evidence suggests that SDCs…
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Bacterial LPS-induced inflammation reduces aquaglyceroporin-mediated glycerol permeability in TM3 mouse leydig cells and is associated with impaired mitochondrial respiration
Inflammation accompanies a wide range of pathological conditions and negatively impacts the male reproductive function by interfering with steroidogenesis and spermatogenesis. Steroidogenesis is sustained by Leydig cells (LCs), but it can be impaired by local or systemic inflammatory events known…
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Mutations in nucleoporins and their roles in human diseases: Integrating evidence on specific NUP functions
Nuclear pore complexes (NPCs), massive assemblies of approximately 30 distinct nucleoporins (NUPs), serve as the major gateways for nucleocytoplasmic transport. Recent research highlights that NUP aberrations—ranging from gene fusions and mutations to pathological protein accumulation—are…
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Spatiotemporal dynamics of epididymal epithelial cells uncover a novel KRT5⁺ATP6V1A⁺ subpopulation of basal cell in postnatal mouse development
Epididymal epithelial cells are critical for sperm maturation. Although previous studies have determined the development of epididymal epithelial cells in rat epididymis, the postnatal developmental trajectories of distinct epithelial cell types in the mouse epididymis remain elusive. Here, we…
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Artikel Jurnal
Potential of a bacterial immunomodulatory enzyme to restore health in a Th1 cytokine cocktail induced skin psoriasis-like model
Psoriasis is a chronic inflammatory disorder driven by immune dysregulation. A common characteristic is hyperproliferation and aberrant differentiation of keratinocytes. Th1-type cytokines, containing TNFα, IL-1α and IL-6, play a role in various cellular processes such as the activation of…
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GOLPH3 depletion in glioblastoma cells promotes anti-tumor effects and neuronal differentiation by affecting mTOR signaling
Glioblastoma is the most aggressive primary brain tumor in adults. Resistance of glioblastoma to the standard chemotherapy agent temozolomide (TMZ) correlates with the expression of the DNA repair enzyme O6-Methylguanine-DNA methyltransferase (MGMT). Additionally, tumor initiation and recurrence…
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Ethanol stress-induced vacuole unlobing is mediated via downregulation of phosphatidylinositol-3,5-bisphosphate and Atg18 phospho-regulation
Ethanol stress in Saccharomyces cerevisiae induces a rapid morphological transition in the vacuole from a multilobed (2–3 lobes) structure to a unilobed form. This change reflects a shift in the dynamic equilibrium between vacuolar fusion and fission, towards fusion. The process is mediated by…
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Epigenetic regulation of non-apoptotic regulated cell death
For decades, apoptosis has reigned supreme in cell death therapeutics, yet its clinical limitations in resistant cancers and degenerative diseases have unveiled the critical role of non-apoptotic regulated cell death (RCD) pathways, including ferroptosis, necroptosis, pyroptosis, and parthanatos…
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Artikel Jurnal
A new photochromic sterol controls TRPC3 activity by actuating a hub of regulatory lipid coordination
Transient receptor potential canonical 3 (TRPC3) is a paradigm of primary lipid-gated ion channels. TRPC3 activity is controlled via regulatory lipid-channel interactions involving multiple lipid coordination sites. Sterols are coordinated as non-annular lipids within TRPC3 channels, while their…