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Journal of Integrative Neuroscience
Scopus
ISSN 0219-6352 · IMR Press · 1.152 artikel di indeks
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Artikel Jurnal
Overexpression of IL7R Attenuates Cerebral Ischemia–Reperfusion Injury by Inhibiting Apoptosis
Background: Cerebral ischemia-reperfusion injury (CIRI) represents the most critical pathological event in the evolution of ischemic stroke (IS). Apoptosis is particularly important in CIRI pathophysiology. The interleukin-7 receptor (IL7R) is involved in various disease regulatory mechanisms…
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Artikel Jurnal
Association of Functional and White Matter Structural Brain Network in Older Cerebral Small Vessel Disease With Cognitive Impairment
Background: To investigate topological brain network properties, intra- and inter-network network patterns, rich-club organization, structural-functional coupling, and their associations with cognitive impairment in elderly patients with cerebral small vessel disease (CSVD). Methods: A total of 264…
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Artikel Jurnal
Adipose-Derived Stem Cells Transfected to Express Brain-Derived Neurotrophic Factor Reduce Hippocampal Amyloid Plaque Load and Improve Dendritic Morphology in the APP/PS1dE9 Mouse Model of Alzheimer’s Disease
Background: Recent studies have indicated that stem cells could provide therapeutic benefits in several neurological conditions, including Alzheimer’s disease (AD). Adipose-derived stem cells (ADSCs) offer many advantages in that they are readily available from individual hosts, are robust, and…
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Artikel Jurnal
Multi-Scale Adaptive Temporal Network for Parkinson’s Motor Symptom Fluctuation Detection Using Coarsened 2D Skeleton Pose Data
Background: Parkinson’s Disease (PD) is a neurological condition characterized by motor symptoms that fluctuate throughout the day depending on medication. Continuous and objective monitoring is essential, but conventional clinical assessments are episodic and subjective, while wearable and…
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Artikel Jurnal
Lutein Attenuates Parkinson’s Disease Progression by Regulating Mitochondrial Function via the TRIM31/Drp1 Signaling Pathway
Background: Mitochondrial dysfunction is closely associated with the pathogenesis of Parkinson’s disease (PD). Lutein has been shown to exert protective effects in neurological disorders. This study aimed to investigate the ameliorative effects of lutein on mitochondrial function in PD and its…
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Artikel Jurnal
The Icelandic Mutation in the Murine APP Gene, mAPPA673T, on Amyloid-β Plaque Burden in the 5×FAD Alzheimer Model
Background: The protective Icelandic mutation in the amyloid precursor protein (APP) gene, APPA673T, identified in Icelandic and other Nordic populations is associated with a significantly lower risk of developing Alzheimer’s disease (AD). Conflicting results have been reported for the human…
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Artikel Jurnal
Glymphatic Clearance Dynamics in Traumatic Brain Injury: Mechanisms, Imaging Biomarkers, and Application Prospects
The pathological increase in brain catabolites after traumatic brain injury strongly correlates with a higher risk of neurodegenerative disease. This review examines the pathogenic role of glymphatic clearance dysfunction in that process. The glymphatic network enables cerebrospinal and…
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Artikel Jurnal
Effect of Maternal Hyperglycemia on Cortical Neuronal Migration: Hypofunction of Reelin Signaling
Background: Maternal diabetes increases the risk of neurodevelopmental alterations in the offspring, yet the molecular links to early corticogenesis remain unclear. During corticogenesis, radial migration is a coordinated process regulated by Reelin signaling and its disruption has been associated…
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Artikel Jurnal
EEG in Insomnia Disorder: Novel Findings and Future Directions
Electrophysiological studies have played a crucial role for the present conceptualization of Insomnia Disorder (ID) as a 24-h disorder characterized by hyperarousal expressed during wakefulness and sleep. In this Opinion piece, we highlight novel findings and delineate relevant future directions in…
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Artikel Jurnal
Electroacupuncture Modulation of Chondroitin Sulfate Glycosaminoglycan Promotes the Repair of Damaged Spinal Cord in Rats
Background: The perineuronal net (PNN) is an important extracellular environment around parvalbumin interneuron (PV IN) in the spinal cord. Chondroitin sulfate proteoglycan (CSPG) serves as a key factor mediating PNN effects on the spinal cord, primarily formed by covalently linked chondroitin…
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Artikel Jurnal
Altered Neural Activity and Functional Connectivity of Dorsolateral Prefrontal Cortex Associated With Cognitive Impairment in Patients With End-Stage Renal Disease
Background: Executive dysfunction is the most prominent feature of cognitive impairment in patients with end-stage renal disease (ESRD). The dorsolateral prefrontal cortex (DLPFC) is a central region for the regulation of executive functions. The aim of our study was to examine alterations in…
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Artikel Jurnal
Roflupram Reduces 6-OHDA-Induced Cellular Damage in SH-SY5Y Cells by Inhibiting PDE4
Background: The main symptoms of Parkinson’s disease (PD) include olfactory impairment and tremor. Current treatment methods for PD generally have limitations such as short duration and severe side effects. The novel phosphodiesterase 4 (PDE4) inhibitor Roflupram (Roflu) mitigates inflammatory…
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Artikel Jurnal
Effect of Physical Activity on Cognitive Function of Patients With Alzheimer’s Disease: A Meta-analysis
Background: Physical activity (PA) is a widely accepted non-pharmacological therapy for patients with Alzheimer’s disease (AD). Existing studies have demonstrated that PA can improve cognitive function in AD patients. However, few of the meta-analyses conducted to date have included participants…
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Artikel Jurnal
Neuroplasticity and Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disease that leads to a decline in cognitive function, including memory. The exact causes of AD are not fully understood, and to date no treatments are available that can stop the progression of this neurocognitive disorder. AD is…
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Artikel Jurnal
Tauroursodeoxycholic Acid Exerts Neuroprotective Effects in Epilepsy via Suppression of Ferroptosis
Background: Epilepsy is a complex neurological disorder marked by recurrent, unprovoked seizures. Ferroptosis is characterized by the accumulation of oxidative stress and is associated with the occurrence and development of epilepsy. Tauroursodeoxycholic acid (TUDCA), a hydrophilic bile acid, has…
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Artikel Jurnal
Exercise Suppresses Insulin Resistance: A Potential Mechanism for Improving the Interaction Between Type 2 Diabetes and Alzheimer’s Disease
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia, hyperinsulinemia, and impaired insulin sensitivity. Although classified as a metabolic disorder, T2DM also contributes to cognitive decline. Alzheimer’s disease (AD) is a progressive and irreversible…
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Artikel Jurnal
Preclinical Study of the Neuroprotective Effects of Pharmacological Agent-Modulators of HSP70 After Intrauterine Hypoxia
Background:Chronic intrauterine hypoxia (IUH) is a cause not only of early postnatal mortality but also of delayed central nervous system (CNS) impairments in offspring, including increased risks of acute cerebrovascular disorders, epilepsy, and neurodegenerative diseases. The above necessitates…
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Artikel Jurnal
Sevoflurane and Aβ1-42 Oligomers Synergistically Induce Morphological Changes of Astrocytes in the Hippocampus of Male Mice
Background:Reactive gliosis serves as a characteristic feature of the pathophysiology of Alzheimer’s disease (AD). Nevertheless, the influence of anesthetics on the morphological dynamics of astrocytes remains ambiguous.Methods:Employing ex vivo hippocampal slices, in this study, we explored the…
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Artikel Jurnal
Neurotrophic Factors in Stroke, Traumatic Brain Injury, and Neurodegeneration: A Convergent Pathophysiological and Translational Perspective
Neurotrophic factors (NTFs), including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), glial cell line-derived neurotrophic factor (GDNF), ciliary neurotrophic factor (CNTF), and vascular endothelial growth factor (VEGF), play a central role in neuronal…
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Artikel Jurnal
Evaluation of the Behavioral and Histopathological Outcomes of Two Cuprizone Administration Routes in a Mouse Model of Multiple Sclerosis
Background:The cuprizone (CPZ) model has been used to study de- and re-myelination in mice; Previous studies have used different routes for CPZ intoxication, but the results were highly variable.Methods:Here, we compared demyelination induced by the administration of 0.3% CPZ mixed with ground…
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