917 hasil
Menampilkan 1–20 · 0,68 detik · RSS
Folia Histochemica et Cytobiologica
Scopus
ISSN 0239-8508 · Via Medica · 917 artikel di indeks
-
Artikel Jurnal
Tectochrysin suppresses the profibrotic phenotype of human keloid fibroblasts and is associated with reduced nuclear p65 accumulation
INTRODUCTION: Keloids are fibroproliferative scars characterized by persistent fibroblast activation and excessive extracellular matrix deposition. Tectochrysin is a natural flavone with anti-inflammatory and anti-oxidative activities, but its effects on keloid fibroblasts remain unclear. MATERIAL…
-
Artikel Jurnal
Fundamental research on the treatment of periodontitis with Kangfuxin (KFX) extended-release gel
INTRODUCTION: Periodontitis, a chronic inflammatory disease that severely compromises oral health and is linked to systemic disorders, has attracted increasing research attention. Kangfuxin (KFX), an ethanol extract derived from Periplaneta americana (L.) with documented anti-inflammatory and…
-
Artikel Jurnal
IGFL2-AS1 knockdown enhances erastin-induced ferroptosis-associated changes in oral squamous cell carcinoma
INTRODUCTION: Long non-coding RNA (lncRNA) IGFL2-AS1 has been implicated in oral squamous cell carcinoma (OSCC) progression, whereas its relationship to ferroptosis remains unclear. Erastin is a small-molecule ferroptosis inducer that inhibits system Xc−, reduces cystine uptake and glutathione…
-
Artikel Jurnal
Esculetin ameliorates sevoflurane-induced cognitive dysfunction in aged mice by suppressing neuroinflammation via inhibition of NF-κB/NLRP3 signaling
INTRODUCTION: The widely used inhalational anesthetic sevoflurane increases susceptibility to postoperative cognitive dysfunction (POCD), especially among the elderly. Esculetin, a natural coumarin compound derived from Cortex Fraxini, possesses anti-inflammatory and neuroprotective activities…
-
Artikel Jurnal
Inhibition of miR-33b-5p promotes osteoblast differentiation by regulating ABCA1 in cellular and animal models of osteoporosis
INTRODUCTION: Osteoporosis is a major health risk for postmenopausal women and is primarily driven by estrogen decline-induced bone loss. As critical post-transcriptional regulators of gene expression, dysregulated microRNAs (miRs) participate in the pathogenesis of osteoporosis by disrupting key…
-
Artikel Jurnal
Lactucin inhibits growth and induces apoptosis in gastric cancer cells by targeting MAPK signaling
INTRODUCTION: Lactucin, a sesquiterpene lactone isolated from chicory (Cichorium intybus L.), demonstrates broad-spectrum anticancer activity across multiple malignancies, yet its mechanistic role in gastric cancer (GC) remains unexplored. This study aimed to elucidate the potential mechanism by…
-
Artikel Jurnal
Ginsenoside Rg3 inhibits Ang II-induced cardiac fibrosis via the GLP-1 receptor signaling pathway
INTRODUCTION: Cardiac fibrosis is a major pathological feature of multiple cardiovascular diseases and an important risk factor for heart failure. Ginsenoside Rg3 (Rg3), a natural triterpenoid saponin extracted from Panax ginseng, has been shown to exert cardioprotective effects. In this study, we…
-
Artikel Jurnal
CRISPR-mediated MLH1 disruption suppresses endometrial cancer growth via genomic instability induction and Wnt/β-catenin pathway inhibition
INTRODUCTION: MutL homolog 1 (MLH1) loss is a defining molecular feature of endometrial cancer (EC) and a principal driver of microsatellite instability (MSI). Ishikawa cells harbor intrinsic MLH1 promoter hypermethylation, resulting in reduced but not abolished MLH1 expression and placing these…
-
Artikel Jurnal
Latent transforming growth factor beta binding protein 1 (LTBP1): roles as a multifunctional extracellular matrix regulator in human disease — from molecular mechanisms to clinical translation prospects
Latent transforming growth factor beta binding protein 1 (LTBP1) is a key regulator of the extracellular matrix (ECM). However, its role as a molecular hub that integrates biochemical signals within the mechanical microenvironment across diverse human diseases has not been systematically…
-
Artikel Jurnal
Exosomal Lnc-DLK1-35 reprograms microglia into a pro-tumorigenic phenotype via a non-canonical cytokine signature to promote glioblastoma progression and chemoresistance
INTRODUCTION: Temozolomide (TMZ) resistance in glioblastoma (GBM) involves dynamic crosstalk of cancer cells with tumor-associated microglia, but the role of exosomal long non-coding RNAs (lncRNAs) remains poorly defined. MATERIAL AND METHODS: We isolated exosomes from TMZ-sensitive (U251) and…
-
Artikel Jurnal
Expression of BDNF–TrkB–AKT1 pathway components and apoptosis-related factors across yak brain regions at low and high altitudes
INTRODUCTION: This study investigated the expression of brain-derived neurotrophic factor (BDNF) signaling components (BDNF–TrkB–AKT1) and apoptosis-related factors (Bcl-2 and Bax) in yak brain regions at different altitudes. MATERIAL AND METHODS: The cerebral cortex, cerebellum, hippocampus…
-
Artikel Jurnal
MOTS-c primes adrenal cortex metabolism without directly driving steroidogenesis
INTRODUCTION: Mitochondrial open reading frame of the 12S rRNA type-c (MOTS-c), a 16-amino acid mitochondrial-derived peptide, regulates cellular metabolism through AMPK and mTOR signaling and exerts protective effects across multiple endocrine tissues. However, its role in adrenal physiology…
-
Artikel Jurnal
Upregulation of SIRT1 ameliorates apoptosis of rat nucleus pulposus cells under oxidative stress through FoxO1/β-catenin pathway
INTRODUCTION: Age-related degenerative changes in intervertebral discs (IVDs) can lead to lower back pain, and even paralysis. This topic is therefore garnering growing attention in an increasingly ageing society. The oxidative stress-induced degenerative process is a major contributor to apoptosis…
-
Artikel Jurnal
Nintedanib alleviates hyperoxia-induced lung injury via targeting NF-κB signalling pathway in rat model of bronchopulmonary dysplasia
INTRODUCTION: Bronchopulmonary dysplasia (BPD) is a common chronic respiratory disease in premature infants. Hyperoxia is the main pathogenic factor of BPD. Nintedanib is a small-molecule tyrosine kinase inhibitor that has been confirmed to affect several cellular processes in different diseases…
-
Artikel Jurnal
Mechanisms of alleviating sepsis-induced rat lung and kidney damage by inhibiting expression of miRNA-939
INTRODUCTION: Sepsis, a life-threatening condition caused by a host response that goes out of control, leads to severe organ dysfunction. MicroRNA 939 (miRNA-939) plays a pivotal role in this process by post-transcriptionally regulating the mRNA expression of key enzymes in the NO/cGMP pathway…
-
Artikel Jurnal
MiR-494-3p knockdown promotes osteogenic differentiation of bone marrow mesenchymal stem cells in ovariectomised rats by targeting Sirt1/TLR4/NF-κB pathway
INTRODUCTION: Osteoporosis is a bone disease characterised by low bone mass, deterioration of bone tissue, and disruption of bone microarchitecture. MicroRNAs have been found to play an important role in osteoporosis. MicroRNA (miR)-494 is inhibited during bone angiogenesis, and its overexpression…
-
Artikel Jurnal
Enhanced migration and adhesion protein expression by polyethylene glycol 4-modified SVVYGLR peptide in an in vitro human gingival fibroblast wound healing model
INTRODUCTION: This study was aimed at exploring the effect of four units of polyethylene glycol (PEG4)-modified Ser-Val-Val-Tyr-Gly-Leu-Arg (SVVYGLR) peptide (SV peptide) on the proliferative potential and migrative capability of human gingival fibroblasts (HGFs) and the activation of…
-
Artikel Jurnal
Electroacupuncture stimulation inhibited astrogliosis and microglia polarisation to alleviate spinal cord injury via Janus kinase 2/signal transducer and activator of transcription 3 signalling pathway
INTRODUCTION: The aberrant activation of the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signalling pathway is involved in spinal cord injury (SCI) progression. Electroacupuncture (EA) stimulation is effective in alleviating SCI, but the mechanism is poorly…
-
Artikel Jurnal
Inhibition of STAT1 alleviates oxidative damage in retinal pigment epithelial cells and exhibits neuroprotective effects in autoimmune optic neuritis by upregulating IFI30 lysosomal thiol reductase
INTRODUCTION: Oxidative damage-induced retinal pigment epithelial (RPE) cell apoptosis and optic nerve inflammation and demyelination are closely related to the pathogenesis of optic neuritis (ON). STAT1 has been found to be activated in the retina and optic nerve of ON rats. This study aimed to…
-
Artikel Jurnal
Expression of O-GlcNAcylation in pulp tissue and dental pulp stem cells of healthy dental organs
INTRODUCTION: O-GlcNAcylation is a post-translational modification in which a single N-Acetyl-D-Glucosamine (GlcNAc) molecule is added to Ser or Thr residues of proteins. The O-N-acetylglucosaminyl transferase (OGT) enzyme is responsible for adding GlcNAc to the target proteins and…