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Iranian Journal of Medical Sciences
Scopus
ISSN 0253-0716 · Shiraz University of Medical Sciences · 1,322 articles in the index
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HTLV-1 and HTLV-2 Seroprevalence among Milk Donors in Shiraz, Southern Iran: A Letter to the Editor
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Personalization of Neonatal Vaccination Timings Based on Established Evidence
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Expression Analysis of VEGF-Related Hub Genes and Pathways in Breast Cancer: A Comprehensive Bioinformatics Analysis
Background: Breast cancer is the most common form of cancer among women worldwide, and the rates of both new cases and deaths have increased over the past two decades. The aim of the study was to identify and validate molecular pathways that could potentially be targeted for therapeutic…
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Innovating Patent Ductus Arteriosus Closure: Preclinical Evaluation of the First Iranian-Developed Nitinol Occluder in a Sheep Model
Background: Patent ductus arteriosus (PDA) is a congenital defect characterized by abnormal blood flow between the aorta and pulmonary artery. Existing closure devices, such as the Amplatzer Duct Occluder (ADO), face challenges with affordability, biocompatibility, and anatomical adaptability. This…
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Exploring Potential Drug-Drug Interactions: A Cross-Sectional Study of 1 Million e-Prescriptions Across Medical Specialties in Shiraz, Iran (2021-2024)
Background: Drug-drug interactions (DDIs) are among the most important medical errors that can lead to adverse effects, increased toxicity, or reduced treatment efficacy. The frequency and severity of DDIs vary across specialties. However, studies covering multiple specialties in Iran are few and…
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Rethinking Neonatal Vaccination Policies: A Neuroimmune Perspective
Neonatal vaccination is a cornerstone of early-life infectious disease prevention. However, the timing and safety of these interventions require careful consideration. This review explored the neuroimmune implications of early immunization, with a specific focus on the interplay between the…
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Antitumor Effects of Apatinib on Tongue Cancer in Patient-Derived Xenograft Models
Background: Tongue cancer is the most common malignant tumor in the oral and maxillofacial region. Novel effective therapies are urgently needed. Apatinib, a small-molecule antiangiogenic tyrosine kinase inhibitor, has demonstrated efficacy in gastric cancer, but its role in tongue cancer remains…
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The Persian Syncope Functional Status Questionnaire: A Validity and Reliability Study
Background: Syncope is defined as a transient loss of consciousness, with vasovagal syncope (VVS) being the most common cause. Although VVS episodes are typically self-limiting, they can significantly impact patients’ quality of life. The syncope functional status questionnaire (SFSQ) is an…
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Seeing Clearly, Worrying Less? Patient Psychology and Radiological Anxiety in the Era of Ultra-Low-Dose CT Imaging
We recently have read with great interest an article entitled “Ultra-Low Dose Computed Tomography Imaging in Quantifying Bone Trauma and Disorders: A Cross-Sectional Study”, by Zarei and colleagues, which was published in your esteemed journal (IJMS Volume 50, Issue 4, April 2025).
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A Novel AP4M1 Variant in an Iranian Child with Spastic Paraplegia 50: A Case Report and Molecular Docking Approach
Spastic paraplegia 50 (SPG50) is a rare autosomal recessive disorder caused by mutations in the AP4M1 gene (OMIM 602296). It is characterized by spasticity, severe intellectual disability, and delayed or absent speech. The present study reported a case from consanguineous parents, where the…
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Prevalence and Risk Factors of Alcohol, Tobacco, and Substance Use among Medical Students in Southern Iran in 2024: A Growing Concern
Background: Alcohol, smoking, and substance use among medical students are significant health concerns that impact their well-being and their future roles as health advocates. This study aimed to investigate the prevalence of these behaviors and related risk factors among medical students in…
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HIV Research Priorities in Iran: Reflections from the Early Years to a New Framework for Action
Reliable and comprehensive data have always been the cornerstone of effective public health planning, and HIV/AIDS is no exception. In this issue of the Iranian Journal of Medical Sciences, Aleebrahim and colleagues present a thoughtful and much-needed contribution by systematically identifying the…
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Retrosternal Burning and Its Endoscopic Associations: Findings from 5,561 Upper Gastrointestinal Endoscopies
Background: Retrosternal burning is often linked to gastroesophageal reflux disease. However, it can also indicate other gastrointestinal disorders. This study aimed to compare and assess upper gastrointestinal (UGI) endoscopic findings in patients with and without retrosternal burning to determine…
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Probiotics Outperform Antioxidants in Improving Semen Parameters of Men with Idiopathic Oligoasthenoteratozoospermia: A Randomized Controlled Trial
Background: Idiopathic oligoasthenoteratozoospermia (iOAT) treatment still poses significant challenges. This study aims to compare the therapeutic efficacy of probiotics on sperm parameters of iOAT patients with placebo and antioxidants.Methods: In this triple-blind, randomized controlled trial…
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The Impact of the COVID-19 Pandemic on Patients with Breast Cancer, Diagnostic Delays and Disease Progression: A Retrospective Study
Background: Breast cancer is the most frequent malignancy among women. The COVID-19 pandemic significantly impacted healthcare systems, potentially affecting the management of this disease. Due to the critical importance of early diagnosis and treatment, and the limited data on the pandemic’s…
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Where Science Meets Devotion: The Lifelong Journey of Professor Mohammad-Reza Panjehshahin
With decades of tireless inquiry and steadfast academic leadership, Professor Mohammad‑Reza Panjehshahin stands as one of the enduring pillars of scientific progress at Shiraz University of Medical Sciences.
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Research Priorities for Human Immunodeficiency Virus and Acquired Immune Deficiency Syndrome in Iran: A Mixed-Methods Study Combining a Systematic Review and Delphi Consensus Approach
Background: In 2022, human immunodeficiency virus (HIV) affected 39 million globally, with Iran experiencing a concentrated epidemic. This study aimed to identify and prioritize critical HIV/AIDS research areas to address existing gaps in the Iranian context.Methods: Researchers at Isfahan…
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Exploring the Adverse Effects of Fenugreek in Humans: A Scoping Review
Background: Trigonella foenum-graecum, commonly known as fenugreek, is used both as a spice and a medicinal herb. While numerous studies investigated its therapeutic effects, this scoping review aimed to explore the reported adverse effects associated with fenugreek consumption in humans. Methods…
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The Gut–Brain Axis in Sleep Deprivation: Mechanisms, Dysbiosis, and Potential Therapeutic Avenues
Sleep is fundamental to metabolic regulation, cardiovascular health, immune balance, and cognitive performance. Emerging evidence indicates that sleep deprivation alters gut microbial communities and immune signaling, thereby influencing the gut-brain axis. This narrative review synthesized current…
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Clinical and Genetic Characterization of Gap Junction Protein β-6 Variants in Non-Syndromic Hearing Loss: A Case Report with Familial Evaluation and In Silico Analyses
Non-syndromic sensorineural hearing loss (NSHL) exhibits substantial genetic heterogeneity, and the identification of its causative variants remains an important challenge. The gap junction protein β-6 (GJB6), expressed in multiple tissues including the sensory epithelium of the inner ear, is…
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