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Upsala Journal of Medical Sciences
Scopus
ISSN 0300-9734 · Upsala Medical Society · 309 artikel di indeks
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Artikel Jurnal
Clinical characteristics of dysplasia in UC and the correlation between dysplasia and UC recurrence
Objective: This research aims to identify the main influencing factors for dysplasia in ulcerative colitis (UC) patients and explored the correlation between dysplasia and the recurrence frequency of UC. Methods: This study retrospectively included 348 UC patients from the outpatient clinic of the…
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Artikel Jurnal
Multiple endocrine neoplasia type 1 with concurrent Cushing’s disease, prolactinoma, and multifocal pancreatic neuroendocrine tumors including insulinoma: a case report
Background: Multiple Endocrine Neoplasia type 1 (MEN1) is an autosomal dominant tumor predisposition syndrome involving primary hyperparathyroidism (PHPT), pituitary neuroendocrine tumors (PitNETs), and pancreatic neuroendocrine tumors. MEN1-associated insulinomas may present with multifocal…
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Artikel Jurnal
Immune checkpoint inhibitor treatment – real-world use and outcomes in Sweden 2015–2023
Background: The introduction of immune checkpoint inhibitor (ICI) treatment has significantly improved the treatment of several cancer diagnoses, such as non-small cell lung cancer, renal and urothelial carcinoma, melanoma. However, there is a lack of real-world data on ICI treatment and outcomes…
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Sex differences in monitoring and achievement of blood pressure and LDL-cholesterol targets in chronic coronary syndrome
Background: The cornerstones of secondary prevention in chronic coronary syndrome (CCS) are blood pressure lowering and lipid-lowering therapy (LLT). The purpose of this study was to examine the control of systolic blood pressure (SBP) and low-density lipoprotein cholesterol (LDL-C) in patients…
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Artikel Jurnal
Altered placental expression of small humanin-like peptides in gestational diabetes mellitus
Background: Gestational diabetes mellitus (GDM) is characterized by maternal insulin resistance and hyperglycemia and has been associated with placental mitochondrial alterations. Small humanin-like peptides (SHLP1–6), encoded within the mitochondrial 16S rRNA region, have been described as…
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Artikel Jurnal
Isolated atrial amyloidosis from atrial natriuretic peptide – a common but overlooked cardiac condition
Interest in the misfolding and aggregation of human proteins into amyloid fibrils has increased dramatically in recent years. The systemic amyloidoses constitute a group of serious disorders that often affect the heart. Each systemic amyloid type is derived from one of several plasma proteins, most…
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Disseminated Ureaplasma infection: a case report of a patient with rheumatoid arthritis on rituximab therapy with multiple abscesses and arthritis
A 51-year-old woman with rheumatoid arthritis treated with rituximab and leflunomide presented with a 5-month history of malodorous vaginal discharge. Initial examination revealed vulvovaginitis and cervicitis, and she was treated with metronidazole and topical corticosteroids. Pelvic ultrasound…
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Artikel Jurnal
Low-intensity pulsed ultrasound restores mitochondrial dynamics and function in lipopolysaccharide-stimulated astrocytes
Background: Low-intensity pulsed ultrasound (LIPUS) is a non-invasive therapeutic modality with growing potential in the treatment of neurodegenerative diseases. However, its mechanistic role in regulating mitochondrial homeostasis in astrocytes under inflammatory stress remains poorly understood…
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Comparison of best corrected visual acuity estimates between a custom-made digital chart and the ETDRS chart
Purpose: To compare best corrected visual acuity (BCVA) measurements obtained using a digital visual acuity chart with those from the gold-standard Early Treatment Diabetic Retinopathy Study (ETDRS) chart and to assess differences in measurement variability and examination time. Methods: Altogether…
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Endocan attenuates LPS-induced alveolar type II cells injury through PI3K/Akt/mTOR pathway
Background: Alveolar type II (AT2) cell injury plays an important role in the pathogenesis of acute lung injury (ALI), but the corresponding treatment options are limited in clinical practice. Endocan has been proved to exert a protective effect in ALI, however, the underlying mechanism remains…
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Artikel Jurnal
Tumor–stroma ratio in colitis-associated colorectal cancer
High stroma content, as measured by tumor-stroma ratio (TSR), is generally a negative prognostic parameter for epithelial cancers, including sporadic colorectal cancer (sCRC). Inflammatory bowel disease patients have higher risk for colorectal cancer than the background population. Evidence…
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Positron Emission Tomography imaging of tumor necrosis factor in lung injury
Introduction: Tumor necrosis factor (TNF) is a key pro-inflammatory cytokine involved in various pulmonary diseases, including idiopathic pulmonary fibrosis (IPF), where it contributes to immune cell recruitment, tissue remodeling, and disease progression. Despite the therapeutic potential of…
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Overview of approved COVID-19 vaccines in the EU, recommendations for use in Sweden and vaccine uptake over time
Objective: The aim of this review is to describe the regulatory background of the COVID-19 vaccines, the national recommendations for use issued and vaccine uptake in Sweden. It includes an overview of licensing and relevant safety aspects identified by the European Medicines Agency (EMA) and the…
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Artikel Jurnal
Factors associated with health-related quality of life 1 year after COVID-19: a cross-sectional study in Sweden
Aims: The main aim of the present study was to identify factors influencing health-related quality of life (HRQoL), as measured by EQ-5D-5L, in individuals 1 year after the acute phase of COVID-19. Methods: This cross-sectional study included 75 participants (51% females), 1 year after confirmed…
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Artikel Jurnal
Avoidable injuries after intervention for abdominal aortic aneurysm: An analysis of negligence claims over 15 years in Sweden
Background: Patients, who are subjected to a patient's injury, are legally allowed a compensation for their suffering. Aim: The negligence claims after surgical treatment of abdominal aortic aneurysms (AAA) registered in the National Swedish patient insurance company (Landstingens Ömsesidiga…
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Artikel Jurnal
Cost-effectiveness analysis of transcatheter aortic valve implantation versus surgical aortic valve replacement in patients with severe aortic stenosis at low risk of surgical mortality in Sweden
Background: Transcatheter aortic valve implantation (TAVI) has shown similar or improved clinical outcomes compared with surgical aortic valve replacement (SAVR) in patients with symptomatic severe aortic stenosis at low risk for surgical mortality. This cost-utility analysis compared TAVI with…
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Artikel Jurnal
Novel diagnostics for improved treatment of gynecological cancer
This paper summarizes the efforts to develop novel biomarkers for diagnosis and screening of the three main gynecological cancers, cervical, endometrial, and ovarian cancer, with an emphasis on research performed during the last 20 years in Uppsala. A cervical cancer screening program has existed…
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Artikel Jurnal
Elevated levels of aquaporin-4-containing extracellular vesicles in cerebrospinal fluid of patients with bipolar disorder
Objectives: To examine a hypothetical dysfunction of the brain water channels in bipolar disorder by analyzing aquaporin-4 (AQP4) exposing extracellular vesicles (EVs) in cerebrospinal fluid (CSF) from individuals with bipolar disorder types 1 and 2, and healthy controls. Methods: We analyzed…
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Artikel Jurnal
Contraceptive choices and satisfaction: a cross-sectional analysis of sociodemographic influences
Introduction: Investigating factors associated with contraceptive satisfaction is important to create a basis for tailored contraceptive counseling. In this study, we aimed to explore how sociodemographic characteristics affected women’s level of satisfaction and choice of different contraceptive…