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The Annual Review of Pharmacology and Toxicology
ISSN 0362-1642 · Annual Reviews · 4 artikel di indeks
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Artikel Jurnal Teks lengkap
Arsenic: A Global Environmental Challenge
Arsenic is a naturally occurring metalloid and one of the few metals that can be metabolized inside the human body. The pervasive presence of arsenic in nature and anthropogenic sources from agricultural and medical use have perpetuated human exposure to this toxic and carcinogenic element. Highly…
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Nanoparticle Toxicology
Nanoparticles from natural and anthropogenic sources are abundant in the environment, thus human exposure to nanoparticles is inevitable. Due to this constant exposure, it is critically important to understand the potential acute and chronic adverse effects that nanoparticles may cause to humans…
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Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span
Senescence is the consequence of a signaling mechanism activated in stressed cells to prevent proliferation of cells with damage. Senescent cells (Sncs) often develop a senescence-associated secretory phenotype to prompt immune clearance, which drives chronic sterile inflammation and plays a causal…
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Artikel Jurnal Teks lengkap
Neuropathic Pain: Mechanism-Based Therapeutics
Neuropathic pain (NeP) can result from sources as varied as nerve compression, channelopathies, autoimmune disease, and incision. By identifying the neurobiological changes that underlie the pain state, it will be clinically possible to exploit mechanism-based therapeutics for maximum analgesic…