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Chinese Medical Journal
Scopus
ISSN 0366-6999 · Wolters Kluwer · 6.477 artikel di indeks
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Artikel Jurnal
Applications and limitations of pluripotent stem cell-derived liver organoids
Abstract. Liver disease is one of leading causes of death worldwide. However, current liver models have limited research progress. Therefore, models that accurately reflect the physiological functions of the human liver are urgently needed in both clinical and laboratory research. Over the past…
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Artikel Jurnal
Global burden and trends of breast cancer: GLOBOCAN 2022 estimates of incidence and mortality in 185 countries
Abstract. Background:. Breast cancer is the most common malignancy among women, posing major health, social, and economic challenges worldwide. This study analyzed global breast cancer incidence and mortality in 2022 using Global Cancer Observatory (GLOBOCAN) 2022 data and projected the disease…
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Artikel Jurnal
Irisin alleviates hepatic steatosis by activating the autophagic SIRT3 pathway
Abstract. Background:. Disruption of hepatic lipid homeostasis leads to excessive hepatic triglyceride accumulation and the development of metabolic dysfunction-associated steatotic liver disease (MASLD). Autophagy, a critical process in liver lipid metabolism, is impaired in MASLD pathogenesis…
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Artikel Jurnal
Biological significance, molecular mechanisms and clinical potential of EI24 in cancer
Abstract. Recent studies have revealed aberrant expression patterns of the autophagy-associated transmembrane protein etoposide-induced 2.4 (EI24) in diverse cancer types, prompting investigations into its potential as a biomarker for cancer. These findings underscore the multifaceted roles of EI24…
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Artikel Jurnal
Burden of liver cancer and underlying etiologies in China from 1990 to 2021: A systematic analysis from the Global Burden of Disease Study 2021
Abstract. Background:. Liver cancer continues to pose a global health challenge. In 2020, China accounted for nearly half of new liver cancer cases worldwide, with a low 5-year survival. This study aims to evaluate the evolving landscape of the liver cancer burden in China. Methods:. Data on…
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Artikel Jurnal
Metabolites beyond metabolism: Exploring their atypical roles in protein modification and signaling transduction
Abstract. This comprehensive review explores the atypical metabolic roles of metabolites, extending beyond their conventional functions in energy production and biosynthesis. It systematically discusses how metabolites serve as substrates for post-translational protein modifications (PTMs)…
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Artikel Jurnal
Chinese Society of Hematology clinical practice guidelines for the comprehensive management of allogeneic hematopoietic stem cell transplantation in patients with severe aplastic anemia
Abstract. Background:. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative treatment for severe aplastic anemia (SAA). In China, the number of SAA patients undergoing allo-HSCT has risen considerably. However, owing to variations in clinical practices between…
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Artikel Jurnal
Efficacy and safety of first-line treatments for metastatic castration-resistant prostate cancer based on phase II and III randomized controlled trials: A PROSTA-MAP systematic review and network meta-analysis
Abstract. Background:. The landscape of metastatic castration-resistant prostate cancer (mCRPC) treatment has evolved greatly; however, limited data are available regarding its relative efficacy and safety. We conducted a systematic review and network meta-analysis to analyze and compare the…
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Artikel Jurnal
Intracranial atherosclerosis increases risk of incident dementia in middle-aged general population
Abstract. Background:. The impact of intracranial atherosclerosis, assessed using precise methods, on cognitive function and dementia remains an area of ongoing research. This study aimed to explore the association of intracranial atherosclerosis with incident dementia in middle-aged community…
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Artikel Jurnal
Modeling epilepsy by loss-of-function of the CUG-binding protein Elav-like family member 2 in zebrafish with multi-omics analysis
Abstract. Background:. The CUG-binding protein Elav-like family member 2 (CELF2) gene has been linked to the pathogenesis of epilepsy, but its precise role remains unclear. This study aimed to investigate the pathogenic mechanisms of CELF2 mutation in epilepsy, utilizing zebrafish models to explore…
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Artikel Jurnal
Decoding GDF15: Impact on prostate cancer metabolism, chemoresistance, and clinical applications
Abstract. Prostate cancer (PCa) presents a significant global health challenge, and cachexia in end-stage PCa further reduces survival time and deteriorates patient quality of life. This necessitates nuanced approaches to prevention, diagnosis, and treatment. This review analyzes the complex role…
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