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Журнал микробиологии, эпидемиологии и иммунобиологии
Scopus
ISSN 0372-9311 · Central Research Institute for Epidemiology · 1,060 articles in the index
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Journal Article
Molecular epidemiology of the nosocomial Salmonella Typhimurium ST328 clone based on whole-genome sequencing data
Background. Salmonella enterica serovar Typhimurium remains one of the leading causes of acute bacterial gastroenteritis worldwide. The emergence and dissemination of high-risk clones with multidrug resistance and capacity for prolonged nosocomial circulation represents a serious public health…
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Journal Article
Rotavirus infection: current state and prospects for control using RNA technologies
Background. Rotavirus infection remains the leading cause of severe gastroenteritis in children under 5 years of age, particularly in low-income countries. Existing live oral vaccines have reduced efficacy in regions with high infection rates, and there is no etiological treatment available…
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Journal Article
The effect of an innovative thiadiazine-class antibacterial agent on the motility of Vibrio cholerae
Introduction. Vibrio cholerae motility plays a key role in the pathogenesis of cholera, so finding ways to suppress it is a promising approach to combating this infection. Objective: to study the effect of Fluorothiazinone on the motility of V. cholerae. Materials and methods. Flagellar motility…
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Journal Article
Immunogenicity of candidate HFRS vaccines based on guinea pig models
Introduction. Cases of hemorrhagic fever with renal syndrome (HFRS) have increased over the past ten years, including in regions previously non-endemic for HFRS. Approximately 98% of all cases in Russia are associated with Puumala hantavirus, while only about 2% of sporadic cases are caused by…
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Journal Article
Development and application of a method for detecting RNA of West Nile virus genotypes 1 and 2 based on loop-mediated isothermal amplification
Introduction. West Nile fever (WNF) is a widespread zoonotic natural focal arbovirus infection. In Russia, intense WNF epidemics are observed in the south and southeast of the European part of the country. Etiotropic treatment and specific immunoprophylaxis for this disease in humans have not been…
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Journal Article
Humoral immunity to seasonal and zoonotic influenza in the population of the Russian Federation in 2021–2025
Introduction. Influenza A virus is one of the major global infectious threats. Along with seasonal epidemics, zoonotic influenza viruses (subtypes А(H5Nх), А(H7Nх), А(H9N2)) pose an increased risk, requiring constant monitoring of herd immunity. The aim of the work was to study human blood sera…
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Journal Article
Identification and multiparametric ranking of candidate genes involved in hepatitis C virus entry and host immune response using bioinformatics methods
Introduction. Hepatitis C virus (HCV) remains a significant public health concern. The application of existing antiviral agents is restricted by their high cost and the development of viral resistance, while vaccine development is impeded by the considerable genetic variability of HCV. The outcome…
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Journal Article
Genetic polymorphism of the р66 gene of Borrelia bavariensis circulating in a natural focus and its association with Ixodid tick-borne borrelioses in the population of the Middle Urals
Introduction. Ixodid tick–borne borrelioses (ITBB) is a naturally occurring focal vector-borne infection. The most common pathogens in Russia are Borrelia garinii, B. afzelii, and B. bavariensis. One of the key factors in their pathogenicity is the surface protein P66, encoded by p66 gene. The…
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Journal Article
The possibilities of using HIV-1 molecular cluster analysis to study the epidemic process of HIV infection
Surveillance of human immunodeficiency virus type 1 (HIV-1) infection has a number of limitations related to the long-term asymptomatic course of the disease, a high level of stigmatization of HIV-infected individuals, as well as the difficulty of collecting information on the mechanisms of HIV-1…
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Journal Article
Reference values for gut microbiota parameters in rhesus macaques established by real-time polymerase chain reaction
Introduction. Reference values for the gut microbiota are essential for a valid assessment of the health status of laboratory primates and for monitoring their keeping conditions. The obtained ranges of gut microbiota parameters are species-specific for rhesus macaques and cannot be directly…
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Journal Article
Attenuated Omicron-like SARS-CoV-2 strain
Introduction. The severe consequences of the COVID-19 pandemic highlight the lack of preparedness of national health systems to counter such biological threats. In this regard, the development of preventive means for specific prophylaxis of COVID-19 and other coronavirus diseases remains urgent…
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Journal Article
Norovirus GII.4 Sydney: origin and global distribution. A systematic review
The emergence of the norovirus GII.4 Sydney variant in 2012 caused a significant worldwide increase in gastroenteritis outbreaks. The article focuses on the problem of the emergence and further spread of the norovirus GII.4 Sydney variant, which is still one of the leading causes of viral…
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Journal Article
Spatiotemporal changes in the incidence of tick-borne encephalitis in the Kirov region over a thirty-year period
The aim of this study was to examine spatio-temporal changes in the incidence of tick-borne encephalitis (TBE) in the Kirov Region over a thirty-year period. Materials and methods. The data used were data on the incidence of TBE in the Kirov Region. Statistical hypotheses were tested at a…
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Journal Article
Epidemiological investigation of hepatitis C virus infections among children in oncohematology departments
The aim of this study was to conduct an epidemiological analysis of hepatitis C infection in children with oncohematological diseases (OHD) using phylogenetic analysis of HCV nucleotide sequences and to analyze the causes and factors of HCV nosocomial transmission. Materials and methods. A…
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Journal Article
Step-by-step protocol for chromogenic immunohistochemical staining of paraffin sections of animal organs in viral infections, using the example of SARS-CoV-2
Introduction. Immunohistochemical (IHC) analysis is one of the main methods for detecting and visualizing the protein determinants of the virus in organs. The nanoscale structures of viruses complicate the visualization of particle topography, which prevents a more detailed understanding of the…
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Journal Article
Features of the gut microbiome in mice with polygenic disorders of energy metabolism
Objective. To identify features of the gut microbiome using 16S rRNA gene sequencing in inbred KK.Cg-a/a (KK) mice and the KK.Cg-Ay/a (Ay) subline with metabolic syndrome (MetS) caused by different genetic disorders, compared to the C57BL/6J (B6) mouse line lacking manifestations of the pathology…
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Journal Article
Borreliella burgdorferi sensu lato infection rates in ticks and small mammals in the Northwestern Federal District of Russia
The aim of this study was to assess detection rates of Borreliella burgdorferi sensu lato DNA in ticks and organs of wild and synanthropic small mammals of the Northwestern Federal District. Materials and methods. Samples of ixodid ticks (n = 4818) and small mammals (n = 960) were examined by…
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Journal Article
Virucidal efficacy of compositions based on lanthanum nitrate hexahydrate
Background. The most urgent problem of medicine is the fight against viral diseases. Preventive measures in the form of antiseptics with virucidal effect (VE) play an important role. Antimicrobial properties have been noted in compounds based on rare-earth metals. The aim of the study was to…
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