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BioTechnologia
Scopus
ISSN 0860-7796 · Termedia Publishing House · 285 articles in the index
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Journal Article
Understanding the biology of mucormycosis using contemporary omics tools: a review
Mucormycosis (the “black fungus infection”) is a life-threatening angioinvasive fungal infection caused by opportunistic fungi of the class Mucormycetes . A lot of clinical exercises were made in the post-coronavirus disease 2019 period due to admission of patients suffering from so called “black…
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Journal Article
Acne vaccine targeting Cutibacterium acnes secretory lipase suppresses the bacteria-induced pro-inflammatory interleukin-6 and macrophage inflammatory protein-2 production
Background Limited attention paid to acne vulgaris has hindered progress in studying its pathological mechanisms and developing new treatments. While direct evidence confirming Cutibacterium acnes (C. acnes) as the initial trigger of acne vulgaris is scarce, the bacterium clearly drives…
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Journal Article
Evaluation of humoral and cellular immune responses induced by a novel YidRv subunit vaccine from hypervirulent Klebsiella pneumoniae
Background Klebsiella pneumoniae (KP) has re-emerged as a prominent etiological agent of pneumonia and systemic infection, with extended-spectrum β-lactamase (ESBL)-producing strains posing considerable therapeutic challenges. Moreover, vaccines may have limited efficacy because of the emergence of…
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Journal Article
In silico investigation of Aloe vera phytoconstituents targeting key proteins involved in atopic dermatitis progression
Background Atopic dermatitis (AD) is a chronic inflammatory skin disease involving complex immune pathways. Natural compounds derived from Aloe vera are attracting increasing attention for their potential in the treatment of dermatological disorders. Material and methods A virtual screening of 110…
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Journal Article
Integrated analysis of usnic acid as a potential inhibitor of dengue NS2B/NS3 protease: DFT, molecular docking, MEP, ADMET, and drug-likeness evaluation
Background The present study aimed to evaluate the inhibitory capability of 10 pyrazole-usnic acid derivatives against dengue virus serotype 2 (DENV-2) NS2B/NS3 serine protease. The crystallographic structure model of the protease enzyme (PDB code: 2FOM) was used to conduct molecular docking…
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Journal Article
In vitro propagation of pascuita (Euphorbia leucocephala Lotsy): effects of different LED light colors on callus, shoots, and root induction
Background The application of different light emitting diodes (LED) light colors in plant micropropagation is gaining prominence based on the morphological and physiological responses of plants when exposed to specific wavelengths and intensities of light. This study aimed to determine the effects…
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Journal Article
Trends in developing nanoparticle-enhanced electrochemical sensors for neurotransmitter detection: a review
Nano-biosensors represent innovative analytical devices that couple nanotechnology with biomolecular recognition elements to detect specific targets with high sensitivity and selectivity. By incorporating nanomaterials such as gold, carbon, or metal oxides, these devices exhibit enhanced…
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Journal Article
Comparative RNA sequencing analysis of resistant and susceptible Dendrobium “Earsakul” under black rot challenge
Background Dendrobium , a highly popular ornamental plant with immense economic significance, is increasingly threatened by black rot disease caused by Phytophthora parasitica . The sole reliance on the use of chemicals to control this disease highlights the need for developing strategies to…
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Journal Article
Challenges in visualizing endogenous loci in the human genome using CRISPR-based imaging systems
One of the major applications of the CRISPR-Cas9 system is the visualization of DNA by using nuclease-deactivated Cas9 (dCas9), which, following complexation with a single-guide RNA (sgRNA), specifically binds to target genomic sequences without inducing DNA breaks. In this approach, either dCas9…
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Journal Article
Antibacterial and antioxidant potentials of larval extract of black soldier fly, Hermetia illucens and blow fly, Lucilia sericata , for biomedical applications
Background This study was conducted to assess the antibacterial and antioxidant activities of the larval extracts of whole black soldier fly, Hermetia illucens , and green bottle blow fly, Lucilia sericata . Material and methods The disk diffusion method was used to determine the antibacterial…
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Journal Article
Effect of PEI25k/DOTAP/cholesterol liposomal formulation on the immunogenicity of SARS-CoV-2 spike protein-encoding DNA vaccine
Background The Coronavirus Disease 2019 (COVID-19) pandemic has highlighted the need to upgrade vaccine strategies. DNA vaccines are advantageous because of their stability and ease of large-scale production; however, they often require adjuvants to boost immune response. Liposomal adjuvants have…
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Journal Article
Synergistic and dose-dependent pharmacological effects of black shallot and nano-curcumin combination on nociceptive, pyretic, and inflammatory responses in murine models
Background Inflammation, pain, and fever are common features of chronic diseases and are often inadequately controlled by existing therapies. This study evaluated a fixed-ratio combination of black shallot extract and nano-curcumin (EBSC) for dose-dependent and synergistic antinociceptive…
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Journal Article
Using physical elicitors to enhance pigment production in Streptomyces sp. VITGV38, and bioactivity and molecular docking studies of the extracted pigment-related compounds
Background Actinomycetes are soil-dwelling microorganisms known for the production of natural pigments, which serve as alternatives to synthetic dyes. In this study, the effects of natural light and total dark conditions on pigment production in Streptomyces sp. VITGV38 (MCC 4869) were examined…
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Journal Article
Biochemical and molecular identification of lactic acid bacteria and yeasts with technological qualities from ogi (a cereal-based fermented food in Nigeria)
Background This study aimed to isolate, characterize, and identify lactic acid bacteria (LAB) and yeasts with technological qualities from spontaneously fermented cereal gruels traditionally known as ogi . Material and methods LAB and yeasts were isolated and screened for pathogenicity tests using…
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Journal Article
Nanotechnology in food systems: opportunities and risks for human health
Nanotechnology has emerged as a promising field with the potential to revolutionize several industries, including the food industry. It offers innovative solutions to critical challenges in food, such as safety, nutrition, waste reduction, and sustainability. This study examines the possibilities…
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Journal Article
Integrated gene expression analysis identifies shared inflammatory and metabolic pathways in polycystic ovarian syndrome, rheumatoid arthritis, and osteoarthritis
Background Polycystic ovary syndrome (PCOS) affects millions of women worldwide and is primarily known for its reproductive and hormonal symptoms. However, growing evidence suggests a strong link between PCOS and inflammation. Rheumatoid arthritis (RA) and osteoarthritis (OA) similarly involve…
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Journal Article
Salinity-driven canthaxanthin enhancement in Chlorosarcinopsis PY02: a practical spot test for microalgal bioprocess optimization
Background As society rapidly ages, the escalating global demand for natural, high-value antioxidants, particularly ketocarotenoids like canthaxanthin, is driving intensive research into their sustainable bioproduction. This study investigates the potential of the green microalga Chlorosarcinopsis…
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Journal Article
Use of biosurfactants, microorganism-destructors, and plants for eco-friendly bioremediation technologies on oil-contaminated soils
Background Soil contamination by oil products is a significant problem that affects the environment, agriculture, economy, and human health, and requires effective solutions. The study aimed to develop effective methods of bioremediation of oil-contaminated soils using microbial preparation D (a…
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Journal Article
Targeting BRAF in cancers – from molecular diagnostics to personalized therapy
Molecular profiling has become a cornerstone of cancer diagnosis and treatment, with BRAF alterations serving as significant markers across various tumor types. The gene encodes a serine/threonine kinase involved in the MAPK/ERK signaling pathway, which regulates cell proliferation and survival…