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European Respiratory Review
Scopus
ISSN 0905-9180 · European Respiratory Society · 1.675 artikel di indeks
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Artikel Jurnal
Murine models of pulmonary fibrosis: mechanisms, limitations and translational insights
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, irreversible interstitial lung disease characterised by excessive collagen deposition, aberrant tissue remodelling, and impaired gas exchange, ultimately leading to respiratory failure and death. IPF carries a poor prognosis, with…
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Artikel Jurnal
Early-life respiratory syncytial virus infection and asthma
Respiratory infections during critical periods of lung development can shape immune responses and cause lasting alterations in pulmonary structure and function. Lung development begins in utero, with airway branching, alveolarisation and epithelial differentiation continuing postnatally, making the…
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Artikel Jurnal
Patient-reported outcome measures applied in chronic diseases relevant to asthma remission: a scoping review
Background Asthma remission is a meaningful treatment goal that requires patient and healthcare provider agreement. However, there is currently no validated way to incorporate patient perspectives of remission in this process. Patient-reported outcome measures (PROMs) can allow comprehensive…
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Artikel Jurnal
Respiratory support in paediatric patients with bronchiolitis: a systematic review and meta-analysis
Background Recent evidence suggests that high-flow nasal cannula (HFNC) may confer better clinical outcomes compared with other respiratory support modalities in paediatric patients with bronchiolitis. Methods We performed a literature search up to 21 January 2024 on PubMed, Scopus, Cochrane…
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Artikel Jurnal
Normal age-related decline in forced vital capacity: a systematic review and meta-analysis
Lung function peaks in early adulthood and declines thereafter, even without respiratory disease. Differentiating physiological ageing from pathological trajectories is critical for diagnosis, prognostication and interpretation of clinical trial end-points, particularly in interstitial lung…
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Artikel Jurnal
The triple-hit hypothesis: exploring pulmonary e-cigarette, PM2.5 and viral polyexposure
Exposure to e-cigarette aerosols, particulate matter with aerodynamic diameter ≤2.5 µm (PM2.5) and respiratory viruses rarely occurs in isolation, but rather in complex polyexposure contexts during daily life. On a cellular and molecular level, vaping induces a distinct lipid-laden macrophage…
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Artikel Jurnal
Vaccinations in patients with interstitial lung diseases: a narrative review
Interstitial lung diseases (ILDs) comprise a heterogeneous group of lung disorders marked by progressive fibrosis and increased vulnerability to respiratory infections, which can trigger sudden outbreaks and worsen outcomes. Vaccination is a key preventive strategy in ILD patients to reduce…
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Artikel Jurnal
Change in pulmonary artery pressure upon acute exposure to high altitude: a systematic review and meta-analysis
Background/research question We investigated the increase in pulmonary artery pressure (PAP) with altitude gain in healthy low-altitude residents travelling to high altitude, analysing reported measures including systolic (sPAP) and mean pulmonary artery pressure (mPAP) and tricuspid regurgitation…
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Artikel Jurnal
East Asia as a sentinel: risk-stratified corticosteroid therapy for paediatric macrolide-resistant Mycoplasma pneumoniae pneumonia
Background Mycoplasma pneumoniae is a major cause of paediatric community-acquired pneumonia. The prevalence of macrolide-resistant M. pneumoniae (MRMP) has exceeded 80% in East Asia, posing significant challenges to clinical management. Increasing evidence suggests that disease progression is…
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Artikel Jurnal
Preclinical human models of primary ciliary dyskinesia
Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder caused by defective motile cilia, resulting in impaired mucociliary clearance, chronic respiratory disease, laterality defects and subfertility. Currently, no disease-modifying treatments exist. Targeting PCD at its root cause…
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Artikel Jurnal
Genetic susceptibility to respiratory health effects from outdoor air pollution: a structured narrative review
Outdoor air pollution exposure is a well-established driver of respiratory disease, while growing evidence highlights an important role for genetic susceptibility. Building on this expanding body of work, our review synthesises findings across studies and provides an integrated overview. Here, we…
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Artikel Jurnal
Frailty and COPD: a bidirectional relationship in the context of systemic and accelerated ageing
Chronic obstructive pulmonary disease (COPD) is increasingly recognised as a systemic disorder that extends beyond the lungs, representing a clinical model of accelerated ageing. Frailty, a multidimensional syndrome characterised by reduced physiological reserve and increased vulnerability to…
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Artikel Jurnal
Large animal models of right heart failure due to pulmonary hypertension: a bridge to translational success
Right heart failure drives morbidity and mortality in pulmonary arterial hypertension (PAH). At present, there are no chronic pharmaceutical interventions that directly augment right heart function in humans despite many promising results in rodent studies. The lack of translational success may be…
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Artikel Jurnal
Comparative response to pharmacological management of asthma in overweight/obese children versus their counterparts: a systematic review and call for data
Background Obese children with asthma experience higher morbidity than their counterparts; whether different treatments should be considered remains to be clarified. Objective To explore the potential group differences in the treatment response to any asthma medications between overweight/obese and…
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Artikel Jurnal
Ageing-associated regenerative failure in the lung: stem cell senescence and transitional cell persistence in idiopathic pulmonary fibrosis
Alveolar regeneration failure due to alveolar stem cell senescence is a defining feature of idiopathic pulmonary fibrosis (IPF), yet the epithelial mechanisms underlying this dysfunction remain incompletely understood. Recent single-cell and lineage-tracing studies have identified distinct…
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Artikel Jurnal
Bench evidence, bedside uncertainty: hyperoxia, mechanical ventilation and lung injury
The management of respiratory failure often necessitates the use of supplemental oxygen and mechanical ventilation, both crucial interventions in critical care. However, this combination of hyperoxia (defined as exposure to supra-atmospheric levels of oxygen) and mechanical ventilation can lead to…
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Artikel Jurnal
Normal limits for the right ventricle-pulmonary circulation exercise echocardiography: a meta-analysis
Normal limits for exercise Doppler echocardiography (ex-TTE) measurements of the right ventricle (RV), pulmonary artery (PA) and left atrial (LA) unit remain inadequately defined. This meta-analysis aims to establish normal limits for measurements of the RV-PA-LA unit. A comprehensive literature…
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Artikel Jurnal
Prediction of PD-L1 expression in nonsmall cell lung cancer using artificial intelligence models based on radiomics: a systematic review and meta-analysis
Background Since 1992, the incidence of lung cancer has shown an overall downward trend, with survival rates significantly improving in recent years due to the application of immune checkpoint inhibitors (ICIs). Assessing programmed death ligand 1 (PD-L1) expression status in lung cancer patients…
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