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Asian Journal of Transfusion Science
Scopus
ISSN 0973-6247 · Wolters Kluwer Medknow Publications · 900 articles in the index
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Journal Article
Rare combination of alloantibodies causing hemolytic disease of the newborn – Challenge for identification
Hemolytic disease of the newborn (HDN) refers to the destruction of the fetal and newborn red cells by maternal red cell antibodies specific for paternally inherited antigens on fetal red cells or erythroid precursors.[1] ABO-incompatibility is the most common cause of HDN. Rh-negative mothers can…
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Journal Article
Role of dithiothreitol in the resolution of pretransfusion immunohematology testing in patients receiving the anti-CD38 monoclonal antibody daratumumab for the treatment of multiple myeloma
INTRODUCTION: Daratumumab (Darzalex; Janssen-Cilag Pty Ltd), an anti-CD38 monoclonal antibody (MoAb), has demonstrated high efficacy in treating relapsed and refractory multiple myeloma (MM). It stands as the pioneering anti-CD38 MoAb approved by the US FDA (2015) and TGA Australia (2017). While…
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Journal Article
Emergency therapeutic leukapheresis: A single-center experience in a teaching hospital in Eastern India
Hyperleukocytosis is a hematologic crisis caused by excessive proliferation of leukemic cells and has a relatively high early mortality due to a series of severe complications needing prompt and effective interventions. Leukapheresis performed using apheresis equipment to separate leukocytes from…
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Journal Article
Adsorption and elution study detected misidentification of para-Bombay phenotype donor in an incompatible crossmatch with Bombay phenotype patient
Bombay and para-Bombay are rare phenotypes with H antigen-deficient red blood cells. A 54-year-old male patient suffering from suspected malignant pleural effusion was planned for thoracotomy. The patient’s blood group showed blood group discrepancy during pretransfusion testing due to ABO…
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Journal Article
Contact dermatitis to a topical formulation of heparin in a blood donor
Contact dermatitis is an inflammatory reaction to an irritant or allergen coming in contact with the skin. In this report, the authors present a case of contact dermatitis in a blood donor, which developed in response to the application of a topical heparin formulation. Topical heparin preparations…
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Journal Article
Transfusion management in two patients with anti-f antibodies – A case report and review of the literature
The anti-f antibody is rarely encountered in the immunohematology laboratory. It is against the compound antigen “ce” or “f.” The “f-“antigen is only expressed when both c and e alleles are present in the cis position on the same haplotype. Anti-f is a clinically significant antibody that can cause…
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Journal Article
Refractory pruritus in cholestatic drug-induced liver injury secondary to androgenic anabolic steroids: Plasmapheresis to the rescue
Anabolic androgenic steroids (AASs) have long been misused by professional athletes. Easy online and over-the-counter availability of AASs makes it an alluring option even among amateurs for their desired cosmetic and performance-enhancing effects. AASs have been associated with distinct forms of…
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Journal Article
Passenger lymphocyte syndrome: Need for consensus on transfusion guidelines and direct anti-globulin test screening in post-liver transplantation period
In post-transplant phase, liver transplant (LT) recipients may experience anemia or hemolysis due to various immune or non-immune reasons and require prompt intervention and timely management. One such instance is when recipients of minor ABO-incompatible LT (ABOiLT) experience delayed hemolysis…
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Journal Article
Poor harvest of peripheral blood stem cells in donor with thalassemia trait
Here, we present a case report detailing a failed harvest from a 3-year-old child, a sibling-matched related donor for a patient with thalassemia undergoing ABO-incompatible hematopoietic stem cell transplant. The initial apheresis procedure, with the donor having an hematocrit of 29.4 and a…
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Journal Article
Antibody-mediated rejection of transplanted kidney associated with anti-Jka alloantibodies: An interesting case report with review of literature
There is increasing evidence for renal expression of non-ABO minor blood group antigens on the renal endothelium of the vasa recta and tubular epithelial cells. The role of antibodies to minor blood group antigens posing as an immunological risk to the transplanted allograft is under-recognized. We…
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Journal Article
Hemolytic disease of fetus due to multiple alloantibodies (anti-D, anti-C, and anti-s) requiring intrauterine transfusions: A case report and review of Indian literature
Immune hemolytic disease of fetus (HDF) and newborn is a serious complication in pregnancy and is associated with perinatal mortality and morbidity. Intrauterine transfusion (IUT) is performed for the treatment of fetal anemia caused by red cell alloimmunization. Here, we present the case of a…
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Journal Article
Role of therapeutic plasma exchange in paraquat poisoning: Our experience
Paraquat poisoning is a leading cause of fatal poisoning in many parts of Asia. It can lead to multiorgan dysfunction. It is actively concentrated in lung tissues leading to pulmonary fibrosis. The case fatality is very high in this herbicide due to the lack of effective treatment options. Here, we…
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Journal Article
Red blood cell alloantibodies dictating solid organ transplant decisions: Two case reports
Presence of antibodies directed against certain red cell antigens in a solid organ transplant recipient can complicate transplant outcome if the donor is positive for those antigen(s). Therefore, these are immunohematological barriers that affect clinical decisions taken in such scenarios. Case A…
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Journal Article
The role of platelet transfusion in modulating platelet indices and leukocyte dynamics in dengue fever patients
Dengue fever, a viral illness transmitted by Aedes mosquitoes, is marked by a reduction in platelet count (PLT) and changes in blood parameters, which increase the risk of complications such as hemorrhage. Platelet transfusion is frequently used to counter thrombocytopenia in dengue cases, but the…
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Journal Article
A whistleblower direct antiglobulin test in chronic kidney disease: An interesting case of occult autoimmune hemolytic anemia in an undiagnosed lymphoma with pure red cell aplasia
A 67-year-old male, presented with urosepsis, severe anemia, advancing azotemia requiring blood transfusion. Patient grouped as O RhD positive. Antibody screening was pan-positive (4+). Similar strong pan-positivity seen on antibody identification with extended cell panel. DAT was 4+ positive for…
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Journal Article
Blood transfusion services in Nepal: An overview
The Nepal Red Cross Society (NRCS) and hospital laboratory services operate blood transfusion services (BTSs) in Nepal. Currently, 121 blood centers in 76 districts of Nepal provide blood donation and transfusion services. The NRCS is involved in almost 90% of Nepal’s blood transfusion-related…
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Journal Article
Rotational thromboelastometry analysis of recovered plasma stored for a long period of time
BACKGROUND AND OBJECTIVES: Although factor VIII (FVIII) is the marker of quality assurance of fresh-frozen plasma (FFP), global tests of coagulation could more accurately reflect the hemostatic profile of FFP. We aimed to evaluate the hemostatic potential of recovered plasma using rotational…
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Journal Article
Rare blood group surveillance among medical undergraduates: Enhancing education, awareness, and donor database development to meet patient needs
BACKGROUND: Maintaining a steady supply of blood, especially rare blood groups, is a challenge for any blood center. This study aimed to assess the knowledge about blood groups and blood donation among undergraduate medical students. This study also analyzed the prevalence of rare blood groups…
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Journal Article
Efficacy of plerixafor in CD34+ stem cell mobilization in healthy pediatric stem cell donors
BACKGROUND AND OBJECTIVES: Efficient stem cell collection from pediatric donors is a common challenge for allogeneic hematopoietic stem cell transplants (HSCT). The addition of plerixafor, a CXCR4 antagonist to standard stem cell mobilization regimens has shown success. We describe our experience…
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Journal Article
Implementation of peer teaching in Transfusion Medicine among phase II medical students: Experience from a tertiary care teaching hospital of Odisha, India
BACKGROUND: Transfusion Medicine (TM) receives varying degrees of attention within undergraduate medical curricula. Effective teaching methods can enhance knowledge of TM among medical students. This study evaluates the effectiveness of peer teaching as a method for improving TM understanding among…