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Shengwu huaxue yu shengwu wuli jinzhan
Scopus
ISSN 1000-3282 · Editorial Office of Progress in Biochemistry and Biophysics · 642 articles in the index
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Journal Article
A Dual Breakthrough in Regulated Cell Death: From Cytoskeletal Disintegration in Anucleate Erythrocytes to Metabolic-immune Synergistic Membrane Lysis
Regulated cell death (RCD) has long been conceptualized as an elaborate program orchestrated by the nucleus and mitochondria in eukaryotic cells. However, this paradigm was fundamentally changed in 2025 by two independent studies published in Cell. One revealed that mature, enucleated erythrocytes…
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Journal Article
Microfluidic-based Pre-amplification-free CRISPR-Cas Biosensing for Rapid Detection: Technologies and Applications
CRISPR-Cas-based biosensing systems have become important platforms for rapid nucleic acid detection because of their programmable sequence recognition and high specificity. In many diagnostic workflows, the CRISPR reaction is coupled with polymerase chain reaction or isothermal pre-amplification…
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Journal Article
High-throughput Meets Visualization: a Microscopy-based CRISPR Screening Platform in Ciliary Biology
While pooled CRISPR screens have revolutionized functional genomics by enabling genome-scale interrogation, they have long faced a fundamental compatibility challenge with high-resolution microscopy-based phenotypes. The core issue lies in the technical disconnect between pooled screening formats…
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Journal Article
Pathological Roles and Regulatory Mechanisms of Macrophage Polarization Imbalance in Steroid-associated Osteonecrosis of The Femoral Head
Steroid-associated osteonecrosis of the femoral head (SANFH) is a progressive osteoarticular disorder associated with prolonged or high-dose glucocorticoid exposure. Its development involves local ischemia, oxidative stress, dysregulated bone metabolism, and disruption of the osteoimmune…
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Journal Article
The Regulatory Mechanism of Ornithine Decarboxylase Antizyme 1 on Polyamine Transport and The Prospect of Tumor Treatment
Polyamine homeostasis is tightly coupled to tumor-cell proliferation, metabolic reprogramming, stress adaptation, and immune escape. Ornithine decarboxylase antizyme 1 (OAZ1) is a central negative regulator of this network. When intracellular polyamine levels increase, the ribosome shifts one…
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Journal Article
Mechanistic Study on IRF7-mediated Regulation of Learning and Memory Function by Aerobic Exercise in Aged Mice
ObjectiveTo explore the mechanism by which aerobic exercise improves hippocampal neuroinflammation and learning and memory ability in brain-aged mice via interferon regulatory factor 7 (IRF7).MethodsA total of 60 male specific pathogen-free (SPF) C57BL/6J mice were enrolled in the experiment…
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Journal Article
Targeting Excessively Accumulated Pathological Tau: PROTAC Molecular Design Strategies and Challenges
The abnormal accumulation, structural change, and spread of tau protein in the brain are now considered important factors in the progression of Alzheimer’s disease (AD) and many other tau-related neurodegenerative diseases. Clinical and pathological studies have shown that the amount and…
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Journal Article
Dynamic Enhancer–promoter Communication Beyond Loop Extrusion
Enhancer-promoter communication is fundamental to the spatial and temporal control of gene expression. Cohesin-mediated loop extrusion has long been considered a major structural mechanism that brings distal regulatory elements into proximity with their target promoters. Recent findings from…
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Journal Article
From Blood-brain Barrier Penetration to Barrier Functional Remodeling: New Intervention Strategies via Nanodelivery Systems for Alzheimer’s Disease
Alzheimer’s disease (AD) is pathologically characterized by cerebral amyloid β‑protein (Aβ) aggregation, neurofibrillary tangles and progressive cognitive deterioration. There is an urgent clinical demand for targeted therapeutic agents against AD, whereas the blood-brain barrier (BBB) acts as a…
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Journal Article
α7 Nicotinic Acetylcholine Receptor: From Structural Mechanisms to Therapeutic Translation
The α7 nicotinic acetylcholine receptor (α7 nAChR) is a ligand-gated ion channel characterized by high Ca2+ permeability, rapid activation, and rapid desensitization. It is widely expressed in the nervous system and various non-neuronal cell types. α7 nAChR is involved in regulating neuronal…
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Journal Article
Kynurenine Pathway and Its Metabolites in Autism Spectrum Disorder: a Close Link
Kynurenine pathway (KP) is a major catabolic route of tryptophan, generating a series of bioactive metabolites including kynurenine, kynurenic acid (KA), quinolinic acid, and 3-hydroxykynurenine. Beyond its fundamental role in amino acid metabolism, KP exerts critical regulatory functions in…
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Journal Article
Microcapsule Matrix Stiffness Regulates Osteogenic Differentiation of Mesenchymal Stem Cells and in vivo Evaluation
ObjectiveThis study aims to investigate the regulatory effects of microcapsules with different matrix stiffness on the survival, proliferation, adhesion, and osteogenic differentiation of mesenchymal stem cells (MSCs), to further explore the relationship between matrix stiffness and MSCs osteogenic…
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Journal Article
Proteomic Profiling of Qi-blood Deficiency vs Damp-heat Syndrome in Colorectal Cancer: Therapeutic Targeting by Astragaloside IV-berberine
ObjectiveColorectal cancer (CRC) is a highly heterogeneous malignancy, and traditional Chinese medicine (TCM) syndrome differentiation is widely used in its clinical management. However, the biological basis underlying different TCM syndromes remains insufficiently understood. This study aimed to…
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Journal Article
MADS-Net: a Multi-scale Attention and Dynamic Sparse Mask Fusion Network for Electrical Impedance Tomography Image Reconstruction in Breast Screening
ObjectiveTo address the key challenges in breast electrical impedance tomography (EIT) reconstruction including the severe ill‑posedness of the inverse problem, limited measurement information from the electrodes, low contrast of small lesions, as well as the common drawbacks of traditional…
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Journal Article
Matrix Stiffness-mediated Regulation of Vascular Regeneration During Tissue Repair
Tissue repair requires the reconstruction of functional vascular networks to restore oxygen and nutrient delivery, eliminate metabolic waste, and maintain tissue homeostasis. Although biochemical factors such as growth factors and cytokines have been extensively studied in vascular regeneration…
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Journal Article
The Dual Roles of ERK Signaling in Parkinson’s Disease: From Neurotoxicity to Neuroprotection
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta and abnormal accumulation of α‑synuclein. Its pathogenesis involves multiple interconnected processes, including oxidative stress…
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Journal Article
Organoid Formation Regulation Through Mechanical Properties of Biomaterials: From Microenvironment Sensing to Physiological and Pathological Remodeling
Organoid technology has become a highly promising in vitro model in biomedical research, but its traditional culture relies on animal-derived basement membrane matrices, which suffer from batch-to-batch variability, undefined biochemical composition, and poorly controllable mechanical properties…
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Journal Article
Electrical Stimulation Combined With Conductive Microgrooves Promotes Neural Differentiation of Stem Cells
ObjectivePeripheral nerve injury is a common clinical condition that can impair the regulatory function of target organs, leading to functional disability; severe injuries may even result in lifelong disability. Therefore, how to effectively promote the morphological and functional reconstruction…
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Journal Article
Study on Tumor Microenvironment With Pump-probe Photoacoustic Tomography Based on a Fast Acquisition Sequence
ObjectiveOxygen partial pressure (pO2) is a critical indicator of the tumor microenvironment and plays an essential role in regulating tumor progression and therapeutic response, particularly for oxygen-dependent treatments such as photodynamic therapy (PDT). Although photoacoustic imaging (PAI)…