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Di-san junyi daxue xuebao
ISSN 1000-5404 · Editorial Office of Journal of Third Military Medical University · 1.215 artikel di indeks
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Artikel Jurnal
Biomarkers for hemorrhagic shock at high-altitude based on metabolomics and machine learning: Identification and validation of D-inositol-4-phosphate, phosalone and methionine
Abstract Objective To systematically investigate the metabolic characteristics of hemorrhagic shock (HS) under simulated high-altitude conditions by integrating metabolomics and machine learning algorithms, and screen the biomarkers for predicting HS under these conditions. Methods Eighty SPF-grade…
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Artikel Jurnal
Characteristics of blood microbiota in high altitude polycythemia patients by 16S rRNA gene sequencing
Objective To investigate the changes in blood microbiota in patients with high altitude polycythemia (HAPC) and the correlation with the risk of HAPC. Methods A cross-sectional trial was carried out among 41 HAPC patients (HAPC group) and 41 healthy plateau individuals (control group) who took…
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Artikel Jurnal
Effect and mechanism of H. pylori in regulation of REDD1 expression in gastric mucosa
Objective Regulated in development and DNA damage responses-1 (REDD1) is a conserved and ubiquitous protein, and is induced in response to multiple stimuli. However, its regulation, function and clinical relevance in Helicobacter pylori (H. pylori)-associated gastritis are presently unknown. The…
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Silencing high mobility group protein B1 inhibits malignant biological behavior of glioblastoma cells
Objective To investigate the effects of high expression of high mobility group protein B1 (HMGB1) on the invasion ability of glioblastoma (GBM) and the efficacy of temozolomide (TMZ) therapy. Methods The HMGB1 sequencing data of 319 GBM samples from TCGA database were gained for differential…
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Artikel Jurnal
Correlation of cumulative exposure to metabolic factors with progression of lower extremity arterial disease in type 2 diabetic patients
Objective To investigate the correlation between cumulative exposure to metabolic factors and progression of lower extremity arterial disease (LEAD) in patients with type 2 diabetes mellitus (T2DM). Methods Clinical data of 157 T2DM patients who were hospitalized to our department for 3 consecutive…
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Artikel Jurnal
Hearing loss and pathogenesis in Graves' disease
Objective To investigate the hearing loss of Graves patients and explore the possible pathogenesis. Methods A total of 39 Graves patients and 22 healthy control subjects who were initially admitted to the outpatient and inpatient departments of our hospital from September 2019 to March 2021 were…
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Artikel Jurnal
Efficacy and safety of unilateral axilla-bilateral areola approach for robotic thyroidectomy versus open surgery for thyroid cancer
Objective To compare the efficacy and safety of unilateral axilla-bilateral areola approach (UABA) for robotic thyroidectomy with conventional open surgery in thyroid cancer patients. Methods We retrospectively analyzed the clinical data of 229 patients who were diagnosed with thyroid cancer and…
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Artikel Jurnal
Calcium-sensing receptor promotes inflammation through TRPC6 channels/Ca2+ signaling in macrophages
Objective To determine the effect of calcium-sensing receptor (CaSR) on inflammation in RAW264.7 cells and elucidate the underlying molecular mechanisms. Methods After Fura-2 fluorescent probe was used to dye intracellular calcium, measurement of intracellular calcium ion concentrations in single…
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Artikel Jurnal
Preparation and effectiveness evaluation of DNA methylation photoelectrochemical sensor based on 3-D rigid DNA bridge nanoprobes
Objective To construct a photoelectrochemical (PEC) sensor based on a 3-dimensional (3-D) rigid DNA bridge nanoprobe for the analysis of DNA methylation sites. Methods Titanium dioxide (TiO2) suspension was dropped onto the surface of ITO electrode to form a thin film; gold nanoparticles (AuNPs)…
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Artikel Jurnal
Morphological characterization of spinal respiratory phrenic motoneurons
Objective To study the spatial distribution of respiratory-related phrenic motoneurons within the spinal cord and comparison of their distribution characteristics with those of deltoid motoneurons and intercostal motoneurons. Methods Using a retrograde tracing strategy from peripheral to central…
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Artikel Jurnal
Induction of heme oxygenase alleviates skeletal muscle atrophy in mice by inhibiting the activation of NLRP3 inflammasome REN Chunguang1, PU Rongxi2, HU Die2, ZHANG Yalian1, CAI Xing1, SHU Bin1, YANG Zhong2
Objective To investigate whether induction of heme oxygenase-1 (HO-1) can reduce skeletal muscle atrophy in mice by inhibiting the activation of NLRP3 inflammasome. Methods Thirty-two 8-week-old male C57BL/6 mice were randomly divided into normal group, model group (the model of lower limb muscular…
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Artikel Jurnal
Value of ambulatory electroencephalogram in evaluation of postoperative withdrawal of antiepileptic drugs in patients with glioma-related epilepsy
Objective To explore whether the abnormality of ambulatory electroencephalogram (AEEG) prior to postoperative drug withdrawal is related to the recurrence of epilepsy after drug discontinuation in patients with glioma related epilepsy (GRE). Methods The clinical data and AEEG of 68 GRE patients who…
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Artikel Jurnal
Ultrasound-guided thoracic paravertebral nerve block in superficial versus deep superior costotransverse ligament: a comparative study of 106 cases
Objective To compare the analgesic effect and postoperative recovery quality of ultrasound-guided superficial and deep injection to superior costal transverse ligament (SCTL) for local anesthetics in thoracic paravertebral block (TPVB) combined with patient-controlled intravenous analgesia (PCIA)…
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Artikel Jurnal
Effects of discoidin domain receptor 1 on intestinal inflammation and fibrosis in experimental colitis mice
Objective To explore the function of discoidin domain receptor 1 (DDR1) in intestinal inflammation and fibrosis in mice with chronic colitis. Methods A 20 bp gRNA sequence targeting exon4 of DDR1 gene was designed and synthesized, and subsequently microinjected into the fertilized eggs of C57BL/6…
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Artikel Jurnal
Percutaneous endoscopic cervical discectomy with lamina-hole approach in treatment of cervical radiculopathy: an analysis of short-term clinical outcomes
Objective To investigate the clinical outcomes of percutaneous endoscopic cervical discectomy with lamina-hole approach for cervical radiculopathy. Methods A retrospective case series study was conducted to analyze clinical data of 30 patients with cervical radiculopathy admitted in our department…
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Artikel Jurnal
Early oral feeding promotes gastrointestinal function recovery for patients after gynecological laparoscopic surgery
Objective To observe the gastrointestinal function recovery in the patients with different feeding time after gynecological laparoscopic surgery. Methods A total of 132 patients undergoing laparoscopic surgery in our department from December 2020 to April 2021 were enrolled in this study. Five of…
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Artikel Jurnal
Auditory brainstem responses during development of MeCP2 autistic mice
Objective To explore the hearing changes in an autism model mice [MeCP2-Tg1 mice, with overexpression of methyl-CpG binding protein 2 (MeCP2)] during development. Methods Three-chamber social test was used to assess the social ability of MeCP2-Tg1 mice and wild-type mice at 8 and 14 weeks after…
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Artikel Jurnal
Efficacy and clinical outcomes of different antiviral regimens in HBeAg/HBeAb double-positive patients with chronic hepatitis B
Objective To analyze the clinical features of HBeAg and HBeAb double-positive patients with chronic hepatitis B, and explore the efficacy and outcomes of different antiviral regimens. Methods A total of 158 HBeAg and HBeAb double-positive patients with chronic hepatitis B who met the antiviral…
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Artikel Jurnal
Blebbistatin ameliorates pneumonic injury after high common bile duct ligation in rats
Objective To investigate the protective effect of blebbistatin, a non-muscle myosin Ⅱ (NMⅡ) inhibitor, on inflammatory injury of lung tissue after chronic common bile duct ligation (CBDL) in rats. Methods A total of 55 SPF male SD rats (200~220 g) were randomly divided into 3 groups, namely control…
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Artikel Jurnal
Benzo[k] fluoranthene induces male germ cell damage
Objective To establish a damage model of mouse spermatocyte GC-2spd cells induced by benzo[k] fluoranthene (BkF), a representative compound of high-molecular weight polycyclic aromatic hydrocarbons, so as to investigate the effect and mechanism of BkF on GC-2 cells. Methods Related genes of male…
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