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ISSN 1001-6325 · Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. · 2.215 artikel di indeks
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Impact of point-of-care ultrasound (POCUS) training on emergency physicians' capacities building in trauma assessment
Objective To evaluate the effectiveness of point-of-care ultrasound (POCUS) training in improving emergency physicians' skill of trauma assessment, confidence, and clinical decision-making capability. Methods TThis was a prospective study involving 80 emergency physicians without POCUS training…
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Screening of soluble hemagglutinin recombinant proteins for influenza virus B/Victoria
Objective To screen the soluble hemagglutinin (HA) recombinant protein derived from B/Victoria lineages of influenza virus that possess hemagglutination activity. Methods Based on the B/Darwin/7/2019 (B/Victoria) strain, HA mutant genes BV-T1, BV-T2, and BV-T3 were obtained by fusing the leucine…
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Characteristics of fecal metabolomics about therapeutic effects of statins for coronary heart disease
Objective To explore the relationship between fecal metabolomics characteristics and the therapeutic effects of statins. Methods Fecal samples were collected from 60 patients with coronary heart disease undergoing statin therapy. Based on whether their low-density lipoprotein (LDL) level were below…
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NG2 expression in primary culture of bone marrow derived-macrophages and its bioactivity
Objective To study the neuron-glial antigen 2(NG2)-positive macrophages and their bioactivity in primary cultured mouse bone marrow derived macrophages. Methods Bone marrow single cell suspension was isolated from femur of 6-8 weeks old Kunming mouse co-cultured with L929 supernatant. NG2…
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Berberine enhances the chemotherapy sensitivity of prostate cancer cell line 22RV1 to docetaxel
Objective To investigate the chemotherapy effectiveness of berberine (BBR) to enhance sensitivity of prostate cancer cell line 22RV1 to docetaxel. Methods The docetaxel (DTX) resistant cell was constructed using prostate cancer cell line 22RV1. The drug-resistant cell strain(22RV1/DTX) was divided…
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Level of serum CHI3L1 and sFlt-1 is correlated with disease severity and prognosis of patients with IgA nephropathy
Objective To investigate the relationship of the serum chitinase-3-like protein 1 (CHI3L1) and soluble fms-like tyrosine kinase-1(sFlt-1) with the severity and prognosis of IgA nephropathy patients. Methods One hundred and twenty-four patients with IgA nephropathy in Third Hospital of Peking…
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Quercetin inhibits TNF-α-induced inflammation of mouse aortic vascular smooth muscle cell line MOVAS
Objective To explore the effect of quercetin(Que)on TNF-α-induced inflammation of vascular smooth muscle cells (VSMCs) and potential mechanism. Methods Mouse aortic vascular smooth cell line MOVAS was exposed to different concentrations of quercetin and the cytotoxicity of quercetin was detected by…
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Level of serum galectin-10,STAT3 and CCL19 is correlated with disease severity in patients with chronic eczema
Objective To investigate potential correlation of serum galectin-10(Gal-10), signal transducer, activator of transcription 3 (STAT3) and C-C chemokine ligand 19 (CCL19) with severity of chronic eczema. Methods TFrom October 2022 to October 2024,104 patients admitted to the 7th People's Hospital of…
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PM2.5 in the air exacerbates lung injury in a mouse model of chronic obstructive pulmonary disease
Objective To investigate the exacerbating effects of fine particulate matter (PM2.5) on lung injury in a chronic obstructive pulmonary disease (COPD) mouse model, and to provide a reliable experimental basis for further research. Methods Mice were randomly divided into four groups: control group…
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Advances in the mechanism of action of the ring finger proteins family in breast cancer
The ring finger proteins(RNFs) family not only function as E3 ubiquitin ligases involved in protein degradation, but also plays crucial roles in regulating various cellular processes such as proliferation, apoptosis, DNA damage repair, tumor immune escape and epigenetic modification. RNFs promote…
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Tamoxifen citrate promotes proliferation of Leydig cell line R2C after treatment with TGF-β1
Objective To investigate the effect of tamoxifen citrate (TCT) on Leydig cell line R2C treated by TGF-β1. Methods R2C cells were used as the research subjects. CCK-8 test was used to detect the effect of different concentration gradients of TCT on the proliferation activity of normal R2C cells to…
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Polyene phosphatidylcholine repairs high glucose-induced human umbilical vein endothelial cells damage
Objective Exploring whether polyene phosphatidylcholine (PPC) has a reparative effect on high glucose-induced functional damage of human umbilical vein endothelial cells (HUVECs). Methods MTT assay was used to detect the effect of PPC on the proliferation activity of HUVECs damaged by high…
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Grifola frondosa polysaccharide improves dexamethasone induced atrophy of myotube models from mouse skeletal muscle cell line C2C12
Objective To investigate the mechanism by which Grifola frondosa polysaccharide (GFP) mitigates dexamethasone (DEX)-induced atrophy of myotubes in mouse skeletal muscle cell line C2C12(C2C12 myotube). Methods C2C12 cells were divided into normal group (NOR), dexamethasone group (DEX), low-dose GFP…
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PHLPP2 variation is associated with prognosis as well as ferroptosis in patients of advanced lung adenocarcinoma harboring EGFR+TP53 co-mutations
Objective To investigate the relationship between the PHLPP2 and the efficacy of targeted combined chemotherapy as well as ferroptosis in patients with advanced lung adenocarcinoma (LUAD) harboring EGFR+TP53 co-mutations. Methods Data of 98 patients with advanced LUAD with EGFR+TP53 co-mutation…
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Gut microbiota dysbiosis and diabetic cardiomyopathy
Dysregulation of gut microbiota and its metabolites contributes to diabetic cardiomyopathy (DCM) primarily through inflammation, oxidative stress, energy metabolism disturbances, insulin resistance, apoptosis and autophagy. Gut microbiota dysbiosis disrupts intestinal barrier function, triggering…
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Clinical value of combined detection of serum sCD40L,ANXA1 and TIM-4 in neonatal bacterial sepsis
Objective To investigate the expression and clinical significance of soluble cluster of differentiation 40 ligand (sCD40L),annexin A1 (ANXA1),T-cell immunoglobulin and mucin domain-containing protein 4 (TIM-4) in the serum of neonates with bacterial sepsis. Methods From September 2022 to March…
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Proteomics of glioblastoma based on microdissection
Objective To analyze differentially expressed proteins in glioblastoma(GBM) tissues and to provide potential clews for early diagnosis of glioblastoma. Methods A total of 27 formalin fixed paraffin embedded(FFPE) specimens of glioblastoma tumor tissues,glioblastoma paired para-neoplastic tissues…
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Hypoxia causes damage to primary cultured human bronchial epithelial cells
Objective To explore the tissue damage and underlying mechanism of hypoxia on human bronchial epithelial cells. Methods Human primary cultured bronchial epithelial cells were divided into three groups: 1)Control group: conventionally cultured in normal environment for 6 hours; 2)Hypoxia group…
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Endovascular transplantation of endothelial progenitor cells co-infected with exogenous Ang-1 and miR-210 promotes angiogenesis in diabetic chronic lower limb ischemia
Objective To investigate the co-modification of endothelial progenitor cells(EPCs) by angiopoietin-1 (Ang-1) and microRNA-210 (miR-210). The anti-apoptosis, migration and angiogenesis promotion of endothelial progenitor cells (EPCs) provide experimental basis for the treatment of diabetic chronic…
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Artikel Jurnal Teks lengkap
Detection of bone mineral density combined with serum 25-(OH)D3 and ucOC assists in the diagnosis of T2DN complicated with sarcopenia
Objective To explore the clinical significance of bone mineral density (BMD),serum 25 hydroxyvita-min D3[25-(OH)D3],uncarboxylated osteocalcin (ucOC) and sarcopenia in patients with type 2 diabetes nephro- pathy(T2DN). Methods From August 2023 to August 2024,197 patients with T2DN admitted to the…
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