2.816 hasil
Menampilkan 1–20 · 0,27 detik · RSS
Zhongguo aizheng zazhi
Scopus
ISSN 1007-3639 · Editorial Office of China Oncology · 2.816 artikel di indeks
-
Artikel Jurnal
Interpretation of the protocol of "artificial intelligence-based subtyping to guide precision therapy for CDK4/6 inhibitor-resistant HR+/HER2- advanced breast cancer—the LINUX study (multicenter, open label, randomized controlled phase Ⅱ platform trial)"
Background and purposeThe LINUX trial is a multicenter, open-label, randomized, controlled phase Ⅱ platform trial designed to continuously enroll patients with hormone receptor (HR)-positive/human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer who have developed…
-
Artikel Jurnal
Loss of Y chromosome and solid tumors in men: research progress and prospects
The incidence and mortality rates of various solid tumors are significantly higher in males than in females, suggesting that sex-related biological factors, such as the Y chromosome, may play an important role in tumorigenesis and tumor progression. Loss of the Y chromosome (LOY), a common somatic…
-
Artikel Jurnal
Chinese expert consensus on imaging‑guided evaluation of resectability for ovarian cancer (2025 edition)
Cytoreductive surgery constitutes the cornerstone of treatment for patients with advanced ovarian cancer. The feasibility of achieving optimal cytoreduction is contingent upon both patient tolerance and surgical resectability. Imaging examinations serve as critical tools for assessing ovarian…
-
Artikel Jurnal
Mechanisms of tumor immune escape mediated by Siglec-15 and advances and prospects in targeted therapy
Immune checkpoint blockade targeting the programmed cell death protein-1 (PD-1) and its ligand PD-L1 has revolutionized cancer immunotherapy; however, a substantial proportion of patients exhibit primary or acquired resistance, underscoring the existence of PD-1 independent immunosuppressive…
-
Artikel Jurnal
BRAF-mutant papillary thyroid carcinoma lymph node metastasis prediction model construction
Background and purposePapillary thyroid carcinoma (PTC) is the most common malignancy of the endocrine system, with its global incidence continuing to rise. The BRAF V600E mutation, as the most common genetic mutation in PTC, is closely associated with aggressive clinicopathological features…
-
Artikel Jurnal
Effects of corylifol A on inhibiting triple-negative breast cancer and inducing autophagy and its potential mechanisms
Background and purposeTriple-negative breast cancer (TNBC) is characterized by strong invasiveness, high recurrence rate, and poor prognosis. Due to the lack of effective targeted therapies, there is an urgent need to find new, efficient therapeutic drugs in clinical practice. Psoralea corylifolia…
-
Artikel Jurnal
The advances and prospects of NSMP subtype of endometrial cancer: from molecular biology to clinical diagnosis and treatment
Endometrial cancer is classified into four subtypes based on molecular characteristics, including polymerase-epsilon-mutated (POLEmut), microsatellite instability-high (MSI-H)/mismatch repair deficient (MMRd), no specific molecular profile (NSMP) and p53 abnormal (p53abn). NSMP subtype, which…
-
Artikel Jurnal
Guideline for Monitoring and Management of Cardiovascular Toxicities Related to Lung Cancer Treatment
Lung cancer remains the most commonly diagnosed cancer and the leading cause of cancer-related deaths in China. Amid population aging and advancements in oncologic care, the comorbidity of lung cancer and cardiovascular disease (CVD) is rising, with CVD now recognized as the second leading cause of…
-
Artikel Jurnal
Clinical implications of tumour and stromal tissues immune cell infiltration in prognostication and immunotherapy response of gastric cancer: a retrospective cohort study
MethodsThis study retrospectively collected clinical specimens and the corresponding clinical information from gastric cancer patients who were treated in Nantong Third People's Hospital from March 2004 to July 2009 and met the inclusion and exclusion criteria of this study. This study used immune…
-
Artikel Jurnal
Characteristics of adverse events of liposomal irinotecan: a real-world study based on the FAERS database
MethodsAdverse event reports related to irinotecan liposome were extracted from the FAERS database from the first quarter of 2004 to the third quarter of 2024. After deduplicating the data, four algorithms: report odds ratio (ROR), proportional reporting ratio (PRR), Bayesian confidence propagation…
-
Artikel Jurnal
Effect of miR-107 targeting NKD1 on mitochondrial oxidative phosphorylation in breast cancer cells
MethodsNKD1 expression in breast cancer was first assessed by analyzing public databases (TNM) and its prognostic significance was evaluated. Additionally, breast cancer and adjacent normal tissue samples were retrospectively collected from patients who underwent surgical resection at the…
-
Artikel Jurnal
Advances in the genomic mutational landscape and therapeutic strategies of male breast cancer
Male breast cancer (MBC) accounts for less than 1% of all breast cancers, but the global incidence rate has increased in recent years. Compared to female patients, MBC typically presents at a later age and possesses distinct molecular biological characteristics. Histologically, MBC usually presents…
-
Artikel Jurnal
Experimental study of autophagic degradation of heavy chain ferritin 1-induced ferroptosis to increase the sensitivity of colorectal cancer to oxaliplatin
MethodsBioinformatics analysis was applied to identify differentially expressed genes between oxaliplatin-sensitive and -resistant cells and their relationship with ferroptosis. Key factors were determined through functional enrichment, prognostic, and interaction network analyses. In vitro…
-
Artikel Jurnal
Progress in clinical exploration of potential novel biomarkers in gastric cancer
Gastric cancer is a highly prevalent malignancy worldwide. Challenges including difficult early diagnosis, substantial inter individual variability in treatment response, limited modalities for recurrence surveillance, and insufficient accuracy of prognostic assessment have long constrained…
-
Artikel Jurnal
SUMO2-mediated SUMOylation of RRM1 regulates gemcitabine resistance in pancreatic ductal adenocarcinoma
MethodsA gemcitabine-resistant PANC1 cell line (PANC1_GR) was established, and the expression of SUMO1, SUMO2, and SUMO3 was assessed by Western blot. The SUMO-activating enzyme inhibitor ML-792 was used to suppress global SUMOylation, and cell proliferation and apoptosis were evaluated using the…
-
Artikel Jurnal
The effect of FGF21 on preadipocyte differentiation and pancreatic cancer fibrosis
MethodsConditioned media were prepared using 3T3-L1 cells at different differentiation stages to observe their effects on Panc02 PC cell clone formation, cell viability, cell cycle, and apoptosis. Panc02 conditioned medium was used to culture 3T3-L1 cells, and the degree of preadipocyte…
-
Artikel Jurnal
Annual progress report on thyroid cancer in 2025 and its perspectives
In recent years, the continuous accumulation of evidence from molecular biology, medical imaging, and evidence-based medicine has driven a systematic reshaping of diagnostic and therapeutic paradigms for thyroid cancer. Differentiated thyroid carcinoma (DTC) is generally associated with a favorable…
-
Artikel Jurnal
Chinese expert consensus on standardized management of PI3K/AKT inhibitor-associated hyperglycemia in breast cancer (2026 edition)
Breast cancer is the most common malignancy among women in China, with approximately 70% of cases being hormone receptor (HR)-positive. Although current therapeutic strategies have significantly improved patient outcomes, endocrine resistance remains a major clinical challenge. Hyperactivation of…
-
Artikel Jurnal
General guidelines for the construction of tumor organoids expert consensus (2026 edition)
Organoid technology, which enables three-dimensional in vitro culture to closely recapitulate key structural and functional features of human tissues and organs, has significant value in disease modeling, precision medicine, and drug discovery and development. With continued advances in organoid…
Menampilkan maksimal 50 halaman. Persempit pencarian dengan filter untuk hasil yang lebih spesifik.