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Cellular Physiology and Biochemistry
Scopus
ISSN 1015-8987 · Cell Physiol Biochem Press GmbH & Co KG · 4.667 artikel di indeks
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Artikel Jurnal
Relationship Between Left Ventricular Remodeling Assessed by Strain Echocardiography and Conventional Echocardiography Before and After Cardiac Resynchronization Therapy in Severe Heart Failure Patients
Background/Aims: To assess the relationship between left ventricular remodeling as evaluated by strain echocardiography and conventional echocardiography before and after cardiac resynchronization therapy (CRT) in patients with severe heart failure patients. Methods: A cross-sectional descriptive…
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Artikel Jurnal
Evidence For a Fibrogenic Interaction Between the Aryl Hydrocarbon Receptor and the Wnt/β-Catenin Pathways in Human Keratinocytes and Fibroblasts
Background/Aims: Systemic sclerosis (SSc) is a rare autoimmune and fibrotic disease, which often manifests in the skin. The aryl hydrocarbon receptor (AHR) is critical for skin homeostasis; however, little is known about its role in fibrosis and SSc. TGFβ, a known target gene of AHR and a…
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Artikel Jurnal
Tumor Destructive Mechanical Impulse (TMI) Treatment of Solid Tumors. Part II: Biomechanics, Computational Simulation, Technical Generator and Applicator Design, and Physiological Effect
Background/Aims: To explore the feasibility and effectiveness of Tumor Destructive Mechanical Impulse (TMI) treatment of solid tumors, biomechanical preconditions for subsequent computational simulation of focused shock wave propagation within cells and tissue are investigated. This innovative…
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Artikel Jurnal
Distinguishing Therapy-Induced Senescence and Polyploid Giant Cancer Cells: Impact on Breast Cancer Chemoresistance
Cellular senescence and polyploid giant cancer cells (PGCCs) constitute distinct, yet interconnected, stress adaptation cellular programs that critically shape breast cancer (BC) progression and therapeutic response. Senescence arises via replicative, oncogene-induced, or therapy-induced…
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Artikel Jurnal
Peripheral miRNA-155 Expression and Circulating Inflammatory Cytokines in Patients with Helicobacter Pylori–Associated Chronic Gastritis: An Exploratory Case–Control Study
Background/Aims: Infection with Helicobacter pylori is the most common cause of chronic gastritis and has been linked to persistent inflammation of the stomach. miRNA-155 and inflammatory cytokines play crucial roles in immune regulation but their systemic profiles of expression are not fully…
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Artikel Jurnal
Regulation of Cellular Signaling by CUL5 is Dependent on Its Neddylation Status
Background/Aims: CUL5 acts as the scaffold protein of the E3 ligase complex in the ubiquitin-dependent protein degradation pathways. Overexpression of CUL5 inhibits cellular proliferation, whereas inhibition of CUL5 expression induces proliferation and can lead to the development of clinical…
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Artikel Jurnal
Bio-Nanoparticle-Induced Self-Defense in Arabidopsis thaliana: Molecular Insights into Resistance Gene Activation Under Smart Industrial Stimuli
Background/Aims: By activating innate immune responses, nanobiotechnology enables sustainable ways to improve the resistance of plants. This study evaluates the effect of chitosan nanoparticles (CNPs) on the transcriptional activation of defense-associated genes of Arabidopsis thaliana. CNPs were…
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Artikel Jurnal
Aging and Infection: Impact of Immunosenescence and Inflammaging in Respiratory Viral Infections
A strong yet appropriate immune response is essential for the timely control and clearing of respiratory viral infections. However, as physical condition declines with age, so does our immune function. Immunosenescence is an age-related immune dysfunction marked by dysregulation of innate immune…
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Artikel Jurnal
The Impact of Aging on Organ Systems in Sickle Cell Disease: a Comparative Review of Physiological Adaptation and Dysfunction
Sickle cell anemia (SCA) is a progressive, systemic disorder that can lead to multi-organ dysfunction. While it has traditionally been most prevalent in regions where malaria is endemic, recent epidemiological studies have shown an increasing disease prevalence in non-endemic areas, primarily…
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Artikel Jurnal
The Effect of 6-Gingerol on Human AML Cell Lines
Background/Aims: Acute myeloid leukemia (AML) is a devastating hematological malignancy without a definitive cure. 6-Gingerol, a bioactive compound, has shown promise in treating various cancers, yet its impact on AML remains elusive. Methods: To elucidate the potential of 6-gingerol in AML, we…
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Artikel Jurnal
Lnc-ANRIL Protects Against Myocardial Ischemia-Reperfusion Injury by Suppressing Ferroptosis via the miR-7238-3p/GPX4 Axis
Background/Aims: Myocardial infarction (MI) remains the leading cause of cardiovascular morbidity and mortality. Although reperfusion therapy restores myocardial blood flow, it also induces myocardial ischemia-reperfusion injury (MI/RI), which worsens prognosis. Ferroptosis, an iron-dependent form…
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Artikel Jurnal
Combined Effects of Toxic Metals and Oxidative Stress on the Development and Health of Sea Trout (Salmo Trutta L.)
Background/Aims: Contaminants in the environment pose a considerable threat to biodiversity, ecological balance, and the health of both wildlife and humans, particularly through the transfer of these harmful substances via fish in the food chain. Methods: This study focused on the developmental…
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Artikel Jurnal
Dapagliflozin, An SGLT2 Inhibitor, Improves Endothelial Cell Energy Metabolism Through Enhanced Mitochondrial Respiration
Background/Aims: Flozins (sodium-glucose cotransporter 2 inhibitors, SGLT2i) are a new class of antidiabetic drugs that reduce cardiovascular mortality and hospitalization rates in heart failure, regardless of type 2 diabetes status. Besides lowering glycemia by inhibiting renal glucose…
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Artikel Jurnal
Ligament Cell Biology: Effect of Mechanical Loading
Ligaments are biomechanically specialized connective tissues that maintain joint stability and guide motion under complex loading conditions. At the cellular and molecular levels, ligament homeostasis is governed by fibroblast-like cells (ligamentocytes) embedded in an intricately organized ECM…
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Artikel Jurnal
Management of Sudden Onset Sensorineural Hearing Loss and the Role of Pentoxyphylline as an Add-on Therapy to Conventional Treatment
Background/Aims: Sudden Sensorineural Hearing Loss (SSNHL) is a rapid-onset condition with varied etiologies, creating uncertainty in optimal treatment strategies. This study aimed to assess whether adding pentoxifylline to standard antiviral and steroid therapy could enhance hearing recovery in…
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Artikel Jurnal
Microbial Desalination Cells: Sustainable Water Desalination Application and Wastewater Management
Background/Aims: Microbial desalination cells (MDCs) are bioelectrochemical systems using electroactive bacteria to generate energy simultaneously cleaning wastewater and desalinating water. This sustainable technology addresses pollution issues and water shortage using an environmentally friendly…
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Artikel Jurnal
Enhancing Cellular Immunity Through Epitope Peptides of SARS-CoV-2 in Individuals with Specific HLA Allele
Background/Aims: This research explores the effectiveness of a new cytotoxic T-cell epitope peptide specific for HLA-A2402 in enhancing cellular immune responses to SARS-CoV-2 infections. HLA molecules play a key role in presenting antigenic epitopes to T cells, with genetic polymorphisms resulting…
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Artikel Jurnal
ACE2 Expression in the Kidneys of Pregnant and Postpartum Rats: Physiological and Pathological Significance During Pregnancy
Background/Aims: Pregnancy is associated with changes in renal hemodynamics, such as increases in renal blood flow and the glomerular filtration rate (GFR). Angiotensin-converting enzyme 2 (ACE2), a transmembrane glycoprotein involved in vasodilation, also acts as a receptor for the entry of severe…
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Artikel Jurnal
Methylglyoxal Reshapes Hepatic and Adipose Tissue Metabolism and Increases Viability of Lymphocytes
Background/Aims: Methylglyoxal (MG) is associated with the development of metabolic disorders that modify the hepatic energetic metabolism in different ways. However, not much is known about the effects of MG on energy metabolism in healthy liver cells. Therefore, this study investigated the…
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Artikel Jurnal
Effective Treatment of Cartilage Abnormalities in Middle-Aged Individuals (Aged 45-60): Bounding Molecular Biology with Microfracture and Hyalofast Membrane Approach Show Positive Outcomes
Background/Aims: In recent years, significant progress has been made in treating cartilage lesions, leading to various techniques aimed at articular surface regeneration. However, the impact of patient age on treatment outcomes remains understudied, despite its recognized influence on…
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