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Dermatologica Sinica
Scopus
ISSN 1027-8117 · Wolters Kluwer Medknow Publications · 972 artikel di indeks
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Artikel Jurnal
Early-onset generalized linear porokeratosis with cutaneous squamous cell carcinomas: A case report and genomic analysis
Previous studies have shown that porokeratosis (PK) arises from mutations in the enzyme-encoding genes – mevalonate kinase, phosphomevalonate kinase, mevalonate diphosphate decarboxylase (MVD), farnesyl diphosphate synthase, and farnesyl-diphosphate farnesyltransferase 1. This study reports a case…
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Artikel Jurnal
Potential causal roles of genetically predicted inflammatory factors in hypertrophic scar formation: A two-sample Mendelian randomization study
Background: Although correlative evidence from observational research points toward an involvement of inflammatory molecules in hypertrophic scar formation, the concrete causal roles and mechanisms linking these elements have not yet been definitively proven. Objectives: This study aimed to explore…
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Artikel Jurnal
Global, regional, and national burden of alopecia areata, atopic dermatitis, and psoriasis, 1990–2021: A systematic analysis for the Global Burden of Disease Study 2021
Background: Three immune-mediated skin diseases, alopecia areata, atopic dermatitis, and psoriasis, impose a substantial burden among nonfatal conditions and are associated with marked cross-regional health disparities. Objectives: This study utilized epidemiological data on three immune-mediated…
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Artikel Jurnal
Comparison and application of the sensitive scale-10 and lactic acid sting test in evaluating sensitive skin
Background: Sensitive skin is a complex syndrome lacking effective assessment and diagnostic methods. Objectives: This study compared the sensitive scale-10 (SS-10) and the lactic acid sting test (LAST) in a preselected cohort of women with self-reported sensitivity, LAST ≥3, and visible erythema…
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Artikel Jurnal
Prevalence, clinical features, and treatment pattern of patients with coexistence of lupus erythematosus and psoriasis: A retrospective study in a single center in Taiwan
Background: Patients with systemic lupus erythematosus (SLE) are at increased risk of developing additional autoimmune disorders. The coexistence of SLE and psoriasis (PSO) is rare but may pose diagnostic and therapeutic challenges. Objectives: This study aimed to compare patients with coexisting…
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Artikel Jurnal
Comparison of topical treatment for vitiligo: A systematic review and network meta-analysis
Background: Vitiligo is an autoimmune-related pigment disorder. Previous studies have demonstrated the therapeutic effects of phototherapy, topical treatments, and systemic immunomodulators in promoting repigmentation in patients with vitiligo. A network meta-analysis can provide the relative…
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Artikel Jurnal
Histone deacetylases: Emerging targets in dermatology
Posttranslational modifications, particularly histone acetylation and deacetylation, regulated by histone acetyltransferases and histone deacetylases (HDACs), play a fundamental role in the epigenetic regulation of gene expression by modulating chromatin structure and accessibility. HDACs are…
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Artikel Jurnal
Human hair follicle epithelial stem cells: Implication on hair diseases pathogenesis and therapeutics
Hair follicle epithelial stem cells (HFeSCs) in the bulge region are emerging targets for therapeutic intervention or candidate for hair regeneration due to their self-renewal capacity and ability to drive the hair cycle. However, most of the current understanding of HFeSCs is based on mouse…
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Artikel Jurnal
Hidradenitis suppurativa in Malaysia: Expert consensus on diagnosis, management, and therapeutic strategies
Hidradenitis suppurativa (HS) is a chronic, relapsing inflammatory skin disorder, affecting intertriginous areas and characterized by painful nodules, abscesses, fistulae, and scarring. Despite its impact on patients’ quality of life (QoL), HS remains underdiagnosed and mismanaged due to its…
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Artikel Jurnal
Oral toxicities associated with immune checkpoint inhibitors: A retrospective cohort study
Background: Oral toxicities associated with immune checkpoint inhibitor (ICI) therapy are increasingly reported. However, the characteristics of clinical, histopathological presentation, and treatment outcome remain poorly defined. Objectives: To comprehensively characterize the clinical…
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Artikel Jurnal
Effects of high and low irradiance excimer light in repigmenting vitiligo: A single-center cross-sectional study
Ultraviolet B (UVB) phototherapy is an important treatment modality for inducing repigmentation in vitiligo. Wavelength and fluence (dose; J/m2) are well-recognized parameters influencing phototherapy outcomes. Irradiance (power density; W/m2), the total photon density received by the skin per unit…
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Artikel Jurnal
Real-world evidence in alopecia areata treatment: A narrative review
Alopecia areata (AA) is a complex autoimmune disorder causing non-scarring hair loss, from localized patches to total scalp or body hair loss. It significantly impacts quality of life, with an unpredictable course that challenges effective management. Traditional treatments like such as…
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Artikel Jurnal
Randomized controlled trial to compare the efficacy of oral minoxidil 1.25 mg versus 2.5 mg versus topical 5% minoxidil in androgenetic alopecia
Background: The first-line pharmacologic treatment for both male and female pattern hair loss is topical minoxidil. Nonetheless, off-label usage of low-dose oral minoxidil has demonstrated good clinical efficacy and safety. Objectives: To study the efficacy of oral minoxidil 1.25 mg and 2.5 mg in…